Additional file 1: Table S1. of The association between maternal use of folic acid supplements during pregnancy and risk of autism spectrum disorders in children: a meta-analysis

Characteristics of the included studies on maternal use of folic acid supplements during pregnancy and risk of autism spectrum disorders in children. (DOC 49 kb

Characteristics of eNOS gene T-786C polymorphism genotype distributions in studies included in this meta-analysis.

<p>Characteristics of eNOS gene T-786C polymorphism genotype distributions in studies included in this meta-analysis.</p

Endothelial NO Synthase Gene Polymorphisms and Risk of Ischemic Stroke in Asian Population: A Meta-Analysis

<div><p>Background</p><p>The association between polymorphism 4b/a, T-786C and G894T in endothelial NO synthase gene (eNOS) and ischemic stroke (IS) remains controversial in Asian. A meta-analysis was performed to better clarify the association between eNOS gene and IS risk.</p> <p>Methods</p><p>Based on the search of PubMed, Web of Science (ISI), CNKI (National Knowledge Infrastructure), Wan Fang Med Online and CBM (Chinese Biology Medical Literature Database) databases, all eligible case-control or cohort studies were identified. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) from fixed and random effect models were calculated. Heterogeneity among studies was evaluated using the I². Meta-regression was used to explore the potential sources of between-study heterogeneity. Begg's test was used to estimate publication bias.</p> <p>Results</p><p>Our study included 27 articles, contained 28 independent case–control studies, involved a total of 3,742 cases and 3,691 controls about 4b/a, 1,800 cases and 1,751 controls about T-786C and 2,747 cases and 2,872 controls about G894T. A significant association of 4a allele with increased risk of IS was found in dominant (FEM: OR = 1.498, 95% CI = 1.329–1.689), recessive (FEM: OR = 2.132, 95% CI = 1.383–3.286) and codominant (REM: OR = 1.456, 95% CI = 1.235–1.716) models. For T-786C and G894T, there were significant associations with dominant and codominant genetic models, but not with recessive genetic model.</p> <p>Conclusions</p><p>The meta-analysis indicated that eNOS gene 4b/a, T-786C, G894T polymorphism might be associated with IS.</p> </div

Additional file 3: Figure S2. of The association between maternal use of folic acid supplements during pregnancy and risk of autism spectrum disorders in children: a meta-analysis

Begg’s funnel plot of the association between maternal use of folic acid supplements during pregnancy compared with those no supplements. (TIFF 116 kb

Characteristics of eNOS gene G894T polymorphism genotype distributions in studies included in this meta-analysis.

<p>Na: not available.</p

Meta-analysis for IS risk depending on the G894T polymorphism in the eNOS gene.

<p>Forest plots of relationship between eNOS gene G894T polymorphism and IS risk in dominant model in Asian. White diamond denotes the pooled OR. Black squares indicate the OR in each study, with square sizes inversely proportional to the standard error of the OR. Horizontal lines represent 95% CIs.</p

Pooled measures on the relationship of eNOS gene 4b/a, T-786C and G894T polymorphism with ischemic stroke.

<p>DHWE: deviated from Hardy–Weinberg equilibrium in controls.</p>a<p>Two articles (Kim et al. Meng et al.) in 4b/a and T-786C and one article (Di et al.) in G894T for recessive model were not sufficient to calculated pooled OR.</p>b<p>One article (Meng et al.) in 4b/a and T-786C and one article (Di et al.) in G894T for recessive model were not sufficient to calculated pooled OR.</p>c<p>p-values was for observed pooled odds ratios. when I²≤50%, it was for FEM, otherwise it was for REM.</p>*<p>Pooled ORs were not calculated for only two articles left sufficient to calculate pooled ORs after excluding articles with OR>3.0.</p><p>FEM, fixed effect model; REM, random effect model</p><p>Dominant model: aa + ba vs. bb for 4b/a, CC + TC vs. TT for T-786C, and TT + GT vs. GG for G894T.</p><p>Recessive model: aa vs. ba + bb for 4b/a, CC vs. TC + TT for T-786C, and TT vs. GT + GG for G894T.</p><p>Codominant model: a vs. b for 4b/a, C vs. T for T-786C, and for T vs. G for G894T.</p

Meta-analysis for IS risk depending on the T-786C polymorphism in the eNOS gene.

<p>Forest plots of relationship between eNOS gene T-786C polymorphism and IS risk in codominant model in Asian. White diamond denotes the pooled OR. Black squares indicate the OR in each study, with square sizes inversely proportional to the standard error of the OR. Horizontal lines represent 95% CIs.</p

Additional file 2: Figure S1. of The association between maternal use of folic acid supplements during pregnancy and risk of autism spectrum disorders in children: a meta-analysis

Flowchart of study selection. (TIFF 102 kb

Characteristics of eNOS gene 4b/a polymorphism genotype distributions in studies included in this meta-analysis.

*<p>Studies deviated from the Hardy-Weinberg equilibrium</p