2 research outputs found
Polydopamine-Coated Polymer Nanofibers for In Situ Protein Loading and Controlled Release
Nanofibrous polymeric materials, combined with protein
therapeutics,
play a significant role in biomedical and pharmaceutical applications.
However, the upload of proteins into nanofibers with a high yield
and controlled release has been a challenging issue. Here, we report
the in situ loading of a model protein (bovine serum albumin) into
hydrophilic poly(vinyl alcohol) nanofibers via ice-templating, with
a 100% protein drug loading efficiency. These protein-loaded nanofibers
were further coated by polydopamine in order to improve the nanofiber
stability and achieve a controlled protein release. The mass ratio
between poly(vinyl alcohol) and bovine serum albumin influenced the
percentage of proteins in composite nanofibers and fiber morphology.
More particles and less nanofibers were formed with an increasing
percentage of bovine serum albumin. By varying the coating conditions,
it was possible to produce a uniform polydopamine coating with tunable
thickness, which acted as an additional barrier to reduce burst release
and achieve a more sustained release profile