Pd(II)-Catalyzed Sequential C–C/C–O Bond Formations: A New Strategy to Construct Trisubstituted Furans

Palladium-catalyzed oxidative difunctionalization of enol ethers with 1,3-dicarbonyl compounds to construct trisubstituted furans in one step under mild conditions is described. The reaction is thought to proceed through a C–C bond formation along with a C–O bond closing the ring structure. Oxygen is the sole oxidant regenerating the Pd(II) catalyst

Access to Thiazole via Copper-Catalyzed [3+1+1]-Type Condensation Reaction under Redox-Neutral Conditions

A new strategy for thiazoles via copper-catalyzed [3+1+1]-type condensation reaction from oximes, anhydrides and potassiumthiocyanate (KSCN) is developed herein. The transformation has good functional group tolerance and various thiazoles were formed smoothly in good to excellent yields under mild reaction conditions. This process involves copper-catalyzed N–O/C–S bond cleavages, activation of vinyl sp² C–H bond, and C–S/C–N bond formations which are under redox-neutral conditions as well as operational simplicity

Palladium-Catalyzed Sequential C–N/C–O Bond Formations: Synthesis of Oxazole Derivatives from Amides and Ketones

A highly efficient method for the synthesis of oxazole derivatives from simple amides and ketones has been established via a Pd­(II)-catalyzed sp² C–H activation pathway in one step. The reaction is supposed to proceed through a C–N bond formation followed by a C–O bond formation closing the ring. Because of the simple and readily available starting materials, easy operation, and high bioactivity of oxazoles, this strategy can be broadly applied to medical chemistry