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A case study : basis for development of a curriculum based on images of self and environment.
<p><b>(a)</b> Right-handed twofold helical chain in 1 linked by intermolecular C–H···π interactions (red dotted line); <b>(b)</b> 3D supramolecular architecture construcated by C–H···π, O–H···O and C–H···O interactions.</p
IC<sub>50</sub> (μM) of all complexes against K-562, HL-60, A549, and HeLa for 48 h treatment.
<p>IC<sub>50</sub> (μM) of all complexes against K-562, HL-60, A549, and HeLa for 48 h treatment.</p
Molecular structures of complex 1, hydrogen atoms are omitted for clarity (Thermal ellipsoids are shown at 50% probability level).
<p>Molecular structures of complex 1, hydrogen atoms are omitted for clarity (Thermal ellipsoids are shown at 50% probability level).</p
Crystal Structure, Cytotoxicity and Interaction with DNA of Zinc (II) Complexes with o-Vanillin Schiff Base Ligands - Fig 5
<p><b>(a)</b> Molecular structures of complex 2, hydrogen atoms are omitted for clarity (Thermal ellipsoids are shown at 50% probability level.); <b>(b)</b> View showing the 3–D structure of complex 2; <b>(c)</b> The independent units A and B appear in pair connecting the infinite chain.</p
UV-Vis absorption spectra of complexes 1 and 2 (10 μM) in the absence and presence of increasing amounts of DNA (0–10 μM).
<p>Arrow shows the absorbance changes upon increasing DNA concentration.</p
Inhibition [%] of complexes 1 and 2 [dose level of 25.0 μM] against human tumor cells.
<p>Inhibition [%] of complexes 1 and 2 [dose level of 25.0 μM] against human tumor cells.</p
Effects of complexes 1 and 2 on the fluorescent spectra of EB–DNA system (λex = 258 nm); CDNA = 30 μM; CEB = 3 μM; from 1 to 6 C<sub>VOL</sub> = 0, 15, 30, 60, 90, 120 μM, respectively; Inset: plot of <i>I</i><sub>0</sub>/<i>I</i> vs <i>r</i> (r = C<sub>VOL</sub>/C<sub>DNA</sub>).
<p>Effects of complexes 1 and 2 on the fluorescent spectra of EB–DNA system (λex = 258 nm); CDNA = 30 μM; CEB = 3 μM; from 1 to 6 C<sub>VOL</sub> = 0, 15, 30, 60, 90, 120 μM, respectively; Inset: plot of <i>I</i><sub>0</sub>/<i>I</i> vs <i>r</i> (r = C<sub>VOL</sub>/C<sub>DNA</sub>).</p
CD-spectra of CT-DNA in the absence and presence of complexes 1 and 2, [DNA] = 100 μM, [VOL] = 0 and 40 μM, respectively.
<p>CD-spectra of CT-DNA in the absence and presence of complexes 1 and 2, [DNA] = 100 μM, [VOL] = 0 and 40 μM, respectively.</p
Syntheses of Schiff base ligands and complexes.
<p>Syntheses of Schiff base ligands and complexes.</p
Di-, tri-, and tetranuclear cobalt, copper, and manganese complexes bridged by <i>μ</i>-hydroxyl groups of tetradentate Schiff base ligands: structures, magnetic properties, and antitumor activities
<div><p>[Co<sub>2</sub>(HL<sup><b>1</b></sup>)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](NO<sub>3</sub>) (<b>1</b>), [Cu<sub>2</sub>(H<sub><b>2</b></sub>L<sup><b>1</b></sup>)(HL<sup><b>1</b></sup>) (CH<sub>3</sub>COO)]·H<sub>2</sub>O (<b>2</b>), [Cu<sub>4</sub>(HL<sup><b>1</b></sup>)<sub>4</sub>(C<sub>2</sub>H<sub>5</sub>OH)]·C<sub>2</sub>H<sub>5</sub>OH·H<sub>2</sub>O (<b>3</b>), and [Mn<sub>3</sub>(HL<sup><b>2</b></sup>)<sub>2</sub>(CH<sub>3</sub>OH)<sub>2</sub>(CH<sub>3</sub>COO)<sub>4</sub>]·2(CH<sub>3</sub>OH)·H<sub>2</sub>O (<b>4</b>) {<b>H</b><sub><b>3</b></sub><b>L</b><sup><b>1</b></sup><b> </b>= 2-ethyl-2-(2-hydroxybenzylideneamino)propane-1,3-diol, <b>H</b><sub><b>3</b></sub><b>L</b><sup><b>2</b></sup><b> </b>= 2-ethyl-2-[(2-hydroxynaphthalene-1-yl)methyleneamino]propane-1,3-diol} have been synthesized and characterized by IR spectra, elemental analyses, single-crystal X-ray diffraction, TGA, XRD, and magnetic measurements. Compound <b>1</b> possesses mixed-valence dinuclear {Co<sub>2</sub>(<i>μ</i><sub>2</sub>-O)<sub>2</sub>} with Co(II) and Co(III) ions linked through <i>μ</i><sub>2</sub>-hydroxyl of Schiff base ligands. Compound <b>2</b> displays a binuclear structure with {Cu<sub>2</sub>(<i>μ</i><sub>2</sub>-O)(<i>η</i><sup>2</sup>-COO)} containing one <i>μ</i><sub>2</sub>-hydroxyl and a single <i>syn–syn</i> acetate bridge. Compound <b>3</b> is tetranuclear with a cube-shaped {Cu<sub>4</sub>(<i>μ</i><sub>3</sub>-O)<sub>4</sub>} core constructed by four Cu(II) centers and four <i>μ</i><sub>3</sub>-hydroxyls of Schiff base ligands. Compound <b>4</b> displays a linear trinuclear {Mn<sub>3</sub>(<i>μ</i><sub>2</sub>-O)<sub>2</sub>(<i>η</i><sup>2</sup>-COO)<sub>2</sub>} structure in which the terminal Mn(III) and the central Mn(II) ions are linked by a <i>μ</i><sub>2</sub>-hydroxyl of Schiff base and two <i>syn–syn</i> acetate bridges. The results show that terminal hydroxyl groups of Schiff base ligands play an important role in assembling polynuclear compounds. Magnetic properties and antitumor activities of these compounds were investigated. The antitumor activities reveal that <b>1</b> and <b>2</b> are more effective antitumor agents for K-562 and HL-60, respectively.</p></div