Demographic and cord blood data for the severe and less severe hyperbilirubinemic groups.

<p>Abbreviations: GA, gestational age; BBW, birth body weight.</p>a<p>Newborns with peak bilirubin concentration <17 mg/dL during the postnatal follow-up period.</p>b<p>Newborns with peak bilirubin concentration ≥17 mg/dL during the postnatal follow-up period.</p

Comparison of demographic and cord blood data between newborns in the less severe hyperbilirubinemic group and the five newborns who developed severe hyperbilirubinemia despite having a low cord blood hydorgen peroxide level.

<p>Abbreviations: GA, gestational age; BW, body weight.</p><p>BW loss: physiological body weight loss = (birth weight−lowest body weight)/birth weight.</p><p>↓ or ↑: beyond mean ±1 standard deviation when compared with the less severe icteric group.</p><p>↑*: bilirubin concentration beyond mean ±0.5 standard deviation when compared with the less severe hyperbilirubinemic group.</p

Clinical characteristics of the study population.

<p>Data are presented as mean±SD or numbers of infants (%). The age was the birth year.</p>a<p>In those <3 years, i.e. born after Jan. 2005, the body weight at first HBV vaccination was >2000 g. For those born before 2005, the first dose was given at body weight >2,200 g.</p

The results of hepatitis B virus serology of the study population.

a<p>Anti-HBs seropositivity: defined as serum level >10 mIU/ml.</p><p>GMT: geometric mean titer.</p

Bilirubin concentrations and hydrogen peroxide levels increased similarly during the first few days.

<p>The correlation between these two variables was 0.454, <i>P</i><0.001. The left y-axis is the bilirubin concentration, whereas the right y-axis is the H₂O₂ (luminol) signal. The y-axis scale is logarithmic because of the high luminal signal values.</p

Receiver operating characteristic (ROC) curve of cord blood hydrogen peroxide (H₂O₂) signals at the peak bilirubin concentration (≥17 mg/dL).

<p>Receiver operating characteristic (ROC) curve of cord blood hydrogen peroxide (H₂O₂) signals at the peak bilirubin concentration (≥17 mg/dL).</p

A scatter plot figure with bilirubin (on the X-axis) and the corresponding hydrogen peroxide levels with Logarithmic transformation (on the Y-axis) was presented.

<p>There is a linear relationship between these 2 values. The regression equation is H₂O₂ signal = 3.371+0.108*Bilirubin. The P value is <0.0001.</p

Enrollment of the study population.

<p>Enrollment of the study population.</p

The different cut-off values of H₂O₂ signal for predicting severe hyperbilirubinemia were compared between the severe hyperbilirubinemic group and the less severe hyperbilirubinemic group.

*<p>Comparison was performed by chi-square test.</p

Maternal hepatitis B carrier status of the study population.

a<p>The percentage was all calculated by case number divided with total number (n = 155).</p>b<p>Maternal HBsAg (+): maternal positive HBsAg tested during pregnancy; Maternal HBeAg (+): maternal positive HBeAg tested during pregnancy;</p