MANet vs VANet- The Applications & Challenges

Vehicular Ad hoc Networks (VANet) and Mobile Ad hoc Networks (MANet) have evolved into one of the very capable fields of research work in wireless networking. VANet is termed as a stimulating form of MANet owing to its highly erratic dynamic topology, frequently occurring disconnections and lifethreateningissues. This paper is a comparative review of MANet, VANet and their applications along with challenges

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca's large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells

Comparison of Conventional Cyclophosphamide versus Fludarabine-Based Conditioning in High-Risk Aplastic Anemia Patients Undergoing Matched-Related Donor Transplantation

Allogeneic stem cell transplant for high-risk aplastic anemia (AA) yields inferior results using conventional cyclophosphamide (CY)-based conditioning. The use of fludarabine (Flu)-based regimens has resulted in improved outcomes in high-risk patients. Limited data are available comparing these two conditioning regimens in such patients. We retrospectively analyzed 192 high-risk patients undergoing matched-related donor transplantation from July 2001 to December 2018. The median age was 19.5 (2–52) years. Patients were divided into 2 groups, Cy200 anti-thymocyte globulin (ATG)20 (Gp1 n = 79) or Flu120–150 Cy120–160 ATG20 (Gp2 n = 113). The risk of graft failure was significantly higher in Gp1, and the majority occurred in patients with >2 risk factors (p = 0.02). The incidence of grade II-IV acute graft versus host disease (GVHD) and chronic GVHD was not significantly different between the two groups. The overall survival (OS) of the study cohort was 81.3 %, disease-free survival (DFS) 76.6 % and GVHD-free relapse-free survival (GRFS) was 64.1%. DFS and GRFS were significantly higher in Gp2 as compared to Gp1: DFS 84.1% versus 68.4 % (p = 0.02), GRFS 77.9% versus 54.4% (p = 0.01), respectively. We conclude that Flu-based conditioning is associated with superior OS, DFS and GRFS as compared to the conventional Cy-based regimen in high-risk AA

Exploring the critical success factors of a resilient supply chain

Abstract This study aims to identify and analyse critical success factors (CSFs) for an organisation aiming for a resilient supply chain. The methodology followed is the systematic analysis of big databases, such as Emerald, Science Direct, and Taylor &amp; Francis, by using a specific set of keywords for filtering. The systematic literature review leads the author to the exploration of several CSFs, followed by their prioritisation by using principal component analysis. The paper highlighted eleven vital CSFs: top management commitment, development of an effective SCM strategy, logistics synchronisation, use of modern technologies, robust information and communication technology, information sharing with SC members, collaborative partnership, improved forecasting, trust development in SC partners, collaborative partnership, strategic partnership, development of reliable suppliers, continuous improvement in the preparedness and response practices, capacity building and training and staff development. The CSFs highlighted in the paper relate to all small and medium-sized enterprises (SMEs). This paper identifies the CSFs for developing a resilient supply chain that is comprehensive and has the potential to address uncertain circumstances. This work is the first of its kind on CSF assessment and categorisation in resilient supply chains.</jats:p

Social Media Marketing Activities: A Tool For Creating Brand Awareness

These days, e-commerce being the latest trend, is developing the inclination of people towards online platforms like social media to get their desired products in best price, ease, less time and increases brand awareness.  If the business has a good social media marketing plan, whereas they manage their online presence in a remarkable manner, then only will brand awareness work in their favor.  The study aims to analyze the mediating effect of brand consciousness as well as value consciousness on brand awareness taking perceived social media marketing activities as the independent variable. Quantitative approach using deduction as a method of hypotheses development has been employed in this study. Structured questionnaire was generated in order to gather data essential for the study.  The data has been collected from 250 university students from Islamabad and Rawalpindi via the convenience sampling technique. The study aspires to analyze the mediating effect of brand consciousness and value consciousness on brand awareness by the impact of perceived social media marketing activities. It was analyzed that social media marketing activities play an important role in having significant impact on brand awareness. Furthermore, brand consciousness and value consciousness also have a mediating impact on the relationship found among social media marketing activities and brand awareness.

Advanced Practice Provider Journal Club

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