JUMP-LANDING KINETIC ASYMMETRIES PERSISTED DESPITE SYMMETRIC SQUAT KINETICS IN COLLEGIATE ATHLETES FOLLOWING ACL RECONSTRUCTION

Anterior cruciate ligament (ACL) re-injury rates are high in collegiate athletes. Squats and countermovement jumps (CMJ) are commonly used for assessments and training after ACL reconstruction (ACLR). The purpose was to quantify the differences and correlations in kinetic asymmetries between squats and CMJs in collegiate athletes following ACLR. Fourteen athletes performed 1-2 squats and CMJs within 24-month following ACLR for a total of 25 assessments. Greater kinetic asymmetries showed in CMJs than squats. Kinetic asymmetries strongly correlated between the ascending and descending phases in squats and moderately between the jumping and landing phases in CMJs. Two phases of squats moderately correlated with the jumping phase of CMJs but the landing phase. CMJ kinetic asymmetries should be directly assessed and trained for mitigating ACL re-injury risk

The influence of migration on the burden of and response to infectious disease threats in China: A theoretically informed review

Massive rural-to-urban migration in China may influence infectious disease spread, but the same powerful social forces that reliably promote migration can also be used to design more effective health systems. The authors systematically reviewed eight databases to identify research studies focused on migrant infectious disease epidemiology and control policies. They examined the sequential phases of rural-to-urban migration (pre-departure, travel, destination, interception, and return) in terms of their influence on infectious disease epidemiology and control policies. The migration process has a profound impact on the distribution of airborne, blood-borne, sexually transmitted, and mosquito-borne infectious diseases in addition to influencing potential control strategies. The spread of vaccine preventable diseases in China underscores the need for more responsive vaccination systems among migrants. Scaling up successful pilot migrant infectious disease control policies and new programmes are urgently needed in order to achieve health equity for Chinese migrants

Beyond Fish and Bicycles: Exploring the Varieties of Online Women’s Ideological Spaces

The Internet has been instrumental in connecting under-represented and vulnerable groups of people. Platforms built to foster social interaction and engagement have enabled historically disenfranchised groups to have a voice. One such vulnerable group is women. In this paper, we explore the diversity in online women’s ideological spaces using a multi-dimensional approach. We perform a large-scale, data-driven analysis of over 6M Reddit comments and submissions from 14 subreddits. We elicit a diverse taxonomy of online women’s ideological spaces, ranging from counterparts to the so-called Manosphere to Gender-Critical Feminism. We then perform content analysis, finding meaningful differences across topics and communities. Finally, we explore two platforms, namely, ovarit.com and thepinkpill.co, where two toxic communities of online women’s ideological spaces (Gender-Critical Feminism and Femcels) migrated after their ban on Reddit

Beyond fish and bicycles: exploring the varieties of online women’s ideological spaces

CNS-1942610 - National Science Foundationhttps://arxiv.org/pdf/2303.07099.pdfAccepted manuscrip

Models of care for frail older persons who present to the emergency department: a scoping review protocol

Background: People aged ≥ 65 years comprise around 1 in 5 emergency department (ED) presentations. Many of these presentations occur due to complications associated with chronic diseases and frailty. This review aims to provide a comprehensive understanding of available research regarding models of care for frail older people presenting to the ED. Methods: The Joanna Briggs Institute scoping review framework will be used to guide this review. Literature searches will be conducted in the following electronic databases (from January 2009 onwards): CINAHL via EBSCOhost, Ovid MEDLINE, Embase, SocINDEX. Grey literature will be identified through searching Google Scholar. This review will consider primary research studies (including observational and interventional studies) published in English on models of care for frail older people (aged ≥ 65) presenting to the ED. Two researchers will independently screen all citations, full-text articles, and abstract data. Potential disagreements will be resolved through discussion with a third researcher. Data extracted from included studies will include the following: author(s), year of publication, country, research design and aim, time frame of the study, study population and sample size, data collection methods, definition of frailty, model of care, and key findings that pertain to the ability to inform this review. The strength of the body of evidence will be assessed using the National Health and Medical Research Council level of evidence hierarchy body of evidence matrix. Data will be presented in a tabular format and accompanied by a narrative that describes the characteristics of the body of literature. Discussion: Despite the increased number of ED presentations for frail older people, there has been no synthesis of the sources of evidence of model of care for frail older people in the setting of emergency care. The results of this scoping review will provide an overview of different models of care and help inform future research in the development of models of care for frail older persons, tailored to the healthcare system in the emergency context. Systematic review registration: This scoping review has been registered in the Open Science Framework (osf.io/h2t94).Full Tex

Mycobacterial RNA isolation optimized for non-coding RNA: high fidelity isolation of 5S rRNA from Mycobacterium bovis BCG reveals novel post-transcriptional processing and a complete spectrum of modified ribonucleosides

A major challenge in the study of mycobacterial RNA biology is the lack of a comprehensive RNA isolation method that overcomes the unusual cell wall to faithfully yield the full spectrum of non-coding RNA (ncRNA) species. Here, we describe a simple and robust procedure optimized for the isolation of total ncRNA, including 5S, 16S and 23S ribosomal RNA (rRNA) and tRNA, from mycobacteria, using Mycobacterium bovis BCG to illustrate the method. Based on a combination of mechanical disruption and liquid and solid-phase technologies, the method produces all major species of ncRNA in high yield and with high integrity, enabling direct chemical and sequence analysis of the ncRNA species. The reproducibility of the method with BCG was evident in bioanalyzer electrophoretic analysis of isolated RNA, which revealed quantitatively significant differences in the ncRNA profiles of exponentially growing and non-replicating hypoxic bacilli. The method also overcame an historical inconsistency in 5S rRNA isolation, with direct sequencing revealing a novel post-transcriptional processing of 5S rRNA to its functional form and with chemical analysis revealing seven post-transcriptional ribonucleoside modifications in the 5S rRNA. This optimized RNA isolation procedure thus provides a means to more rigorously explore the biology of ncRNA species in mycobacteria.Singapore-MIT Alliance for Research and TechnologyNational Institute of Environmental Health Sciences (ES017010)National Institute of Environmental Health Sciences (ES002109)Singapore-MIT Alliance (Graduate Fellowship)Singapore. National Research Foundatio

Validated age and growth estimates for Carcharhinus obscurus in the northwestern Atlantic Ocean, with pre- and post management growth comparisons

This paper is not subject to U.S. copyright. The definitive version was published in Environmental Biology of Fishes 97 (2014): 881-896, doi:10.1007/s10641-013-0189-4.Age and growth estimates for the dusky shark, Carcharhinus obscurus, were derived from vertebral centra collected in the northwestern Atlantic Ocean. Sample collection spanned the years prior to and following the implementation of management measures (1963–2010). Growth was compared pre- and post- population depletion and pre- and post- management to investigate the possibility of density-mediated shifts in age and growth parameters over time. There was no evidence of difference between periods for either sex. Additionally, bomb radiocarbon dating was used to determine the periodicity of band pair formation. Results support the traditional interpretation of annual band pairs up to approximately 11 years of age. After this time, vertebral counts considerably underestimate true age. Maximum validated ages were estimated to be between 38 and 42 years of age (an increase of 15 to 19 years over the band count estimates), confirming longevity to at least 42 years of age. Growth curves estimated using only validated data were compared to those generated using band pair counts. Logistic growth parameters derived from validated vertebral length-at-age data were L ∞  = 261.5 cm FL, L o  = 85.5 cm, t o  = 4.89 year and g = 0.15 year−1 for the sexes combined. Revised estimates of age at maturity were 17.4 years for males and 17.6 years for females

The Deadly Business of an Unregulated Global Stem Cell Industry

In 2016, the Office of the State Coroner of New South Wales released its report into the death of an Australian woman, Sheila Drysdale, who had died from complications of an autologous stem cell procedure at a Sydney clinic. In this report, we argue that Mrs Drysdale's death was avoidable, and it was the result of a pernicious global problem of an industry exploiting regulatory systems to sell unproven and unjustified interventions with stem cells.Research for this paper was supported with the funding from an Australian Research Council Linkage Project Grant (LP150100739) and the National University of Singapore, Office of the Deputy President (Research and Technology)—Humanities and Social Sciences Research Fund (WBS: R-171-000-055-646)

The VOICE study – a before and after study of a dementia communication skills training course

Background A quarter of acute hospital beds are occupied by persons living with dementia, many of whom have communication problems. Healthcare professionals lack confidence in dementia communication skills, but there are no evidence-based communication skills training approaches appropriate for professionals working in this context. We aimed to develop and pilot a dementia communication skills training course that was acceptable and useful to healthcare professionals, hospital patients and their relatives. Methods The course was developed using conversation analytic findings from video recordings of healthcare professionals talking to patients living with dementia in the acute hospital, together with systematic review evidence of dementia communication skills training and taking account of expert and service-user opinion. The two-day course was based on experiential learning theory, and included simulation and video workshops, reflective diaries and didactic teaching. Actors were trained to portray patients living with dementia for the simulation exercises. Six courses were run between January and May 2017. 44/45 healthcare professionals attended both days of the course. Evaluation entailed: questionnaires on confidence in dementia communication; a dementia communication knowledge test; and participants’ satisfaction. Video-recorded, simulated assessments were used to measure changes in communication behaviour. Results Healthcare professionals increased their knowledge of dementia communication (mean improvement 1.5/10; 95% confidence interval 1.0–2.0; p<0.001). Confidence in dementia communication also increased (mean improvement 5.5/45; 95% confidence interval 4.1–6.9; p<0.001) and the course was well-received. One month later participants reported using the skills learned in clinical practice. Blind-ratings of simulated patient encounters demonstrated behaviour change in taught communication behaviours to close an encounter, consistent with the training, but not in requesting behaviours. Conclusion We have developed an innovative, evidence-based dementia communication skills training course which healthcare professionals found useful and after which they demonstrated improved dementia communication knowledge, confidence and behaviour