Los mundos [teóricos] de Coraline: Psicoanálisis, Postfeminismo y Postmodernismo en el cine de animación

[ES] Este artículo contribuye al estudio de diferentes metodologías como modo de aproximación al estudio teórico sobre la animación, utilizando como caso de estudio la película de animación Los Mundos de Coraline (Henry Selick, 2009), que incorpora a su complejo hilo argumental ideas procedentes de diversos movimientos histórico-sociales y filosóficos. Además, esta investigación justifica la necesidad de integrar en el actual cine de animación una fuerte inspiración teórica en la narrativa, además de las innovaciones tecnológicas que se desarrollan paralelamente. A través de la revisión de esta producción animada, se alega que los personajes animados pueden y deben ser protagonistas de narrativas tan profundas como las que aquí se tratan, ya que la animación tiene la potencialidad de incidir profundamente en cuestiones como la confirmación de la identidad o el desarrollo cognitivo del personaje protagonista, a través de la simbólica visualización de sus experiencias, miedos y frustraciones en el camino hacia su madurez.Martínez González, E. (2011). Los mundos [teóricos] de Coraline: Psicoanálisis, Postfeminismo y Postmodernismo en el cine de animación. Con A de Animación. (1):79-96. doi:10.4995/caa.2011.8627996

CLEAR-AI: empowering people living with dementia and their carers to understand and reduce distress

People living with dementia sometimes present with behaviours that carers find difficult to understand and manage. These include aggression, pacing, vocalising, exit-seeking and sexually inappropriate behaviour. They can be present in up to 70% of people living with dementia and often present because of misunderstanding or because of the distress the person experiences trying to cope with the daily challenges of living with their illness. These behaviours increase the risk that a person will move from their home to a care home. CLEAR Dementia Care© helps carers to understand behaviour in the context of the person and their environment, identify unmet needs and respond in ways to reduce distress. We present the pilot of “CLEAR-AI”, an artificial intelligence (AI) powered platform that interprets data from a range of connected smart sensors, apps and devices to model the person with dementia’s daily routines. Analysis of the data and training the AI model enables the platform to identify the triggers that precede distress episodes and to recognise when episodes occur in the context of previous activities in the day. Using these models, and with CLEAR’s assessment as baseline, we can initiate interventions into daily schedules that reduce or mitigate distress where it is likely to arise. The goal is to reduce carer burden and enable the person to live at home with as much independence as possible for as long as possible. Our consortium brings together people living with dementia and their carers, commissioners of digital social care, specialists in dementia care, AI and digital solutions. The co-design approach ensures that we are led by stakeholders’ needs to improve quality of life

The Gastric Microbiota Invade the Lamina Propria in <i>Helicobacter pylori</i>-Associated Gastritis and Precancer

Background: Stomach cancer is the fourth leading cause of cancer-related deaths worldwide. Helicobacter pylori is the main risk factor for gastric adenocarcinoma (GAC), yet the precise mechanism underpinning this association remains controversial. Gastric intestinal metaplasia (GIM) represents the precancerous stage and follows H. pylori-associated chronic gastritis (CG). Sequencing studies have revealed fewer H. pylori and more non-H. pylori bacteria in GAC. However, the spatial organization of the gastric microbiota in health and disease is unknown.Materials and Methods: Here, we have combined RNA in situ hybridization and immunohistochemistry to detect H. pylori, non-H. pylori bacteria, and host cell markers (E-cadherin, Mucins 5AC and 2) on tissue sections from patients with CG (n = 15) and GIM (n = 17).Results: Quantitative analysis of whole slide scans revealed significant correlations of H. pylori and other bacteria in CG and GIM. In contrast to sequencing studies, significantly fewer non-H. pylori bacteria were detected in H. pylori-negative patients. Importantly, whilst H. pylori exclusively colonized the gastric glands, non-H. pylori bacteria invaded the lamina propria in 6/9 CG and 8/10 GIM H. pylori-positive patients. A rapid and cost-effective modified Gram stain was used to confirm these findings and enabled detection of non-H. pylori bacteria in GIM samples.Conclusions: The invasion of the gastric lamina propria by non-H. pylori bacteria during H. pylori-associated CG and GIM represents an overlooked phenomenon in cancer progression. Further work must determine the mechanisms underlying the synergistic roles of H. pylori and other bacteria in carcinogenesis. This observation should redirect attempts to prevent, diagnose, and treat GAC

Near-Infrared Monitoring of Volatiles in Frozen Lunar Simulants While Drilling

In Situ Resource Utilization (ISRU) focuses on using local resources for mission consumables. The approach can reduce mission cost and risk. Lunar polar volatiles, e.g. water ice, have been detected via remote sensing measurements and represent a potential resource for both humans and propellant. The exact nature of the horizontal and depth distribution of the ice remains to be documented in situ. NASA's Resource Prospector mission (RP) is intended to investigate the polar volatiles using a rover, drill, and the RESOLVE science package. RP component level hardware is undergoing testing in relevant lunar conditions (cryovacuum). In March 2015 a series of drilling tests were undertaken using the Honeybee Robotics RP Drill, Near-Infrared Volatile Spectrometer System (NIRVSS), and sample capture mechanisms (SCM) inside a 'dirty' thermal vacuum chamber at the NASA Glenn Research Center. The goal of these tests was to investigate the ability of NIRVSS to monitor volatiles during drilling activities and assess delivery of soil sample transfer to the SCMs in order to elucidate the concept of operations associated with this regolith sampling method

A FAIR guide for data providers to maximise sharing of human genomic data

It is generally acknowledged that, for reproducibility and progress of human genomic research, data sharing is critical. For every sharing transaction, a successful data exchange is produced between a data consumer and a data provider. Providers of human genomic data (e.g., publicly or privately funded repositories and data archives) fulfil their social contract with data donors when their shareable data conforms to FAIR (findable, accessible, interoperable, reusable) principles. Based on our experiences via Repositive (https://repositive.io), a leading discovery platform cataloguing all shared human genomic datasets, we propose guidelines for data providers wishing to maximise their shared data’s FAIRness. Citation: Corpas M, Kovalevskaya NV, McMurray A, Niel

Health Related Quality of Life in Adult Low and High-Grade Glioma Patients Using the National Institutes of Health Patient Reported Outcomes Measurement Information System (PROMIS) and Neuro-QOL Assessments

Health related quality of life (HRQOL) measures have become increasingly important in the management of glioma patients in both research and clinical practice settings. Functional impairment is common in low-grade and high-grade glioma patients as the disease has both oncological and neurological manifestations. Natural disease history as well as medical or surgical treatment can negatively influence HRQOL. There are no universal standards for HRQOL assessment in glioma patients. In this study, we examine patient perspectives on functional outcome domains and report the prevalence of impairments rates using the National Institutes of Health (NIH) Patient Reported Outcomes Measurement Information System (PROMIS) and Neuro-QOL item banks as measures of HRQOL. Retrospective analysis of a prospectively collected dataset involving 79 glioma patients reveals that quality of life concerns are the most important consideration behind making decisions about treatment in 80.7% of patients. The prevalence of functional impairment by PROMIS and NEURO-QOL assessment is high, ranging from 28.6% in the physical function domain to 43.9% in the cognitive function domain. Pain and anxiety related to physical decline is higher in LGG patients compared to HGG patients. Aphasia severity also impacts HRQOL. The results of this study suggest that the PROMIS and NEURO-QOL assessments may be important HRQOL metrics for future use in larger clinical research and clinical trial settings

Transcriptional Landscape of the Prenatal Human Brain

Summary The anatomical and functional architecture of the human brain is largely determined by prenatal transcriptional processes. We describe an anatomically comprehensive atlas of mid-gestational human brain, including de novo reference atlases, in situ hybridization, ultra-high resolution magnetic resonance imaging (MRI) and microarray analysis on highly discrete laser microdissected brain regions. In developing cerebral cortex, transcriptional differences are found between different proliferative and postmitotic layers, wherein laminar signatures reflect cellular composition and developmental processes. Cytoarchitectural differences between human and mouse have molecular correlates, including species differences in gene expression in subplate, although surprisingly we find minimal differences between the inner and human-expanded outer subventricular zones. Both germinal and postmitotic cortical layers exhibit fronto-temporal gradients, with particular enrichment in frontal lobe. Finally, many neurodevelopmental disorder and human evolution-related genes show patterned expression, potentially underlying unique features of human cortical formation. These data provide a rich, freely-accessible resource for understanding human brain development