A Participatory Approach to FCS Food, Nutrition, and Wellness Program Planning

To help fill programming gaps in a more organized and collaborative manner, a participatory approach to program planning was tested in Virginia. Programming gaps related to food, nutrition, and wellness programs were filled through a participatory process that involved: an online needs assessment survey; a systematic review of evidence- and practice-based programs; a webinar providing an overview of possible programs for adoption; a program ranking survey; development of an evaluation template; a training; and feedback survey. Our results indicate that a systematic, team-based approach to program planning may be beneficial in guiding trainings and dissemination of programs within Extension

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

The Iowa Homemaker vol.36, no.16

Clothes for College, Jackie Andre, page 5 Home Economics has Grown, Jackie Andre, page 6 This is Your Future, Lee Klinzman, page 7 From College to Internship to Job, Donna Schneider, page 8 Another Catering Party is Underway, Ginny Joy, page 9 Opportunities in Home Economics, Bonnie Rollins, page 10 A Part-Time Job, Pat McBride, page 12 Scholarships are Available, Jan Anderson, page 14 Creative Holiday in Mexico, Nancy Fox, page 15 The Kashmir Goat, Norma Scholes, page 16 Religious Customs Concerning Food, Ann Baur, page 1

The Iowa Homemaker vol.35, no.7

New England by Garfield, Mary Vandecar, page 5 Where else but at college?, Ruth Abbott, page 6 Kitchen formula #1: recipes, Pat McBride, page 7 Our Des Moines apartment, Marilyn Martin, page 8 Our near-campus apartment, Barbara Culver, page 9 Practice makes prize-winning pies, Sally Rosenquist Bennett, page 10 New life for the landings, Lee Klinzman, page 12 What’s New, Mary Anne Larson, page 13 Trends – Scandinavian art, Donna Danielson, page 1

The Iowa Homemaker vol.35, no.12

The Family Gives Thanks, Dr. E. W. Remley, page 5 Better Planning For Better Living, Margot Copeland, page 6 To Win, Decorate Your Room!, page 8 “Sweater Dress-Up”, Sue Mullins, page 10 Introducing: Rose Liu From Formosa, Margot Copeland, page 11 Dr. P. Mabel Nelson, Amy Millen, page 12 Extra Dollars For You, Marilyn Ogland, page 14 Connaisseur De La Cuisine, Martha Burleigh and Martha Elder, page 15 Trends To A New Figure, Anne Beem, page 16 Glasses… For Modern Lasses, Donna Schneider, page 17 What’s New, Pat McBride, page 1

Identification of a BRCA2-Specific modifier locus at 6p24 related to breast cancer risk

Common genetic variants contribute to the observed variation in breast cancer risk for BRCA2 mutation carriers; those known to date have all been found through population-based genome-wide association studies (GWAS). To comprehensively identify breast cancer risk modifying loci for BRCA2 mutation carriers, we conducted a deep replication of an ongoing GWAS discovery study. Using the ranked P-values of the breast cancer associations with the imputed genotype of 1.4 M SNPs, 19,029 SNPs were selected and designed for inclusion on a custom Illumina array that included a total of 211,155 SNPs as part of a multi-consortial project. DNA samples from 3,881 breast cancer affected and 4,330 unaffected BRCA2 mutation carriers from 47 studies belonging to the Consortium of Investigators of Modifiers of BRCA1/2 were genotyped and available for analysis. We replicated previously reported breast cancer susceptibility alleles in these BRCA2 mutation carriers and for several regions (including FGFR2, MAP3K1, CDKN2A/B, and PTHLH) identified SNPs that have stronger evidence of association than those previously published. We also identified a novel susceptibility allele at 6p24 that was inversely associated with risk in BRCA2 mutation carriers (rs9348512; per allele HR = 0.85, 95% CI 0.80-0.90, P = 3.9×10−8). This SNP was not associated with breast cancer risk either in the general population or in BRCA1 mutation carriers. The locus lies within a region containing TFAP2A, which encodes a transcriptional activation protein that interacts with several tumor suppressor genes. This report identifies the first breast cancer risk locus specific to a BRCA2 mutation background. This comprehensive update of novel and previously reported breast cancer susceptibility loci contributes to the establishment of a panel of SNPs that modify breast cancer risk in BRCA2 mutation carriers. This panel may have clinical utility for women with BRCA2 mutations weighing options for medical prevention of breast cancer

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat

The Geology of The Mt. Simon Sandstone Storage Complex at the Wabash #1 Well, Vigo Co., Indiana (Subtask 7.2, Technical Report)

The Wabash CarbonSAFE project drilled the Wabash #1 stratigraphic test well (ID# 168045) at the Wabash Valley Resources (WVR) IGCC facility in Vigo County, Indiana, to characterize and evaluate the basal Cambrian Mt. Simon Sandstone for commercial-scale CO2 storage near the site. This report presents an extensive geologic characterization of the Mt. Simon storage complex and relevant data collected from the Wabash #1 well, such as lithologic data collected from cuttings and core, geophysical logging, geomechanical analysis of core samples, and well testing and fluid sampling within the Mt. Simon Sandstone. The Mt. Simon storage complex comprises two major sections: the Mt. Simon Sandstone as the potential reservoir and the overlying Eau Claire Formation as its primary seal. Within the report, an extensive depositional, sedimentological, and geochronologic characterization of the Mt. Simon is included with supportive chapters on the regional geology and the geophysical, petrophysical, and petrologic data collected during the project. An overview of 2D seismic reflection data collected from and around the test well is presented. Also presented are chapters on the characterization of the sealing Eau Claire Formation, including a chapter on the capacity of the primary and secondary seals to the Mt. Simon as well as a chapter on geomechanical testing results of the Eau Claire Formation and Mt. Simon Sandstone. Some of the information discussed in this report was used in the development of static and dynamic geologic models of the Mt. Simon Sandstone storage complex. The static and dynamic modeling of CO2 injection in the Mt. Simon Sandstone are discussed in a separate report (Dessenberger et al., 2022) under the Wabash CarbonSAFE project