Synthesis of Homochiral Dihydroxy-4-nitroisoxazolines via One-Pot Asymmetric Dihydroxylation−Reduction

Herein we report a one-pot procedure to prepare a family of homochiral dihydroxy-4-nitroisoxazolines 3. This new methodology affords the title compounds in good yields, excellent enantiopurity, and without the use of chromatography

Synthesis of Homochiral Dihydroxy-4-nitroisoxazolines via One-Pot Asymmetric Dihydroxylation−Reduction

Herein we report a one-pot procedure to prepare a family of homochiral dihydroxy-4-nitroisoxazolines 3. This new methodology affords the title compounds in good yields, excellent enantiopurity, and without the use of chromatography

Studies on the Generation of Unnatural <i>C</i>-Nucleosides with 1-Alkynyl-2-deoxy-d-riboses

1-Alkynyl-2-deoxy-d-riboses 7 and 8 were independently synthesized and subsequently used to generate several novel C-nucleosides

Synthesis of Homochiral Dihydroxy-4-nitroisoxazolines via One-Pot Asymmetric Dihydroxylation−Reduction

Herein we report a one-pot procedure to prepare a family of homochiral dihydroxy-4-nitroisoxazolines 3. This new methodology affords the title compounds in good yields, excellent enantiopurity, and without the use of chromatography

Generation of Acylnitroso Dienophiles: A Study of Metal Catalysis

Four novel metal/amine catalysts efficiently converted Boc-NHOH to its acylnitroso species at 5 mol % catalyst loading. These reactions allowed the preparation of polyfunctional hetero Diels−Alder adducts in high yield and from truly commercially available materials

Multicomponent Synthesis of 3-Heteroarylpropionic Acids

A four component one-pot procedure (4-MC) was developed to assemble 3-heteroarylpropionic acids from commercially available materials. This new methodology affords the title compounds in high yields and without the use of chromatography

Multicomponent Synthesis of 3-Indolepropionic Acids

A three-component one-pot procedure (3-MC) was developed to assemble 3-indolepropionic acids from commercially available materials. This new methodology affords the title compounds in high yields and without the use of chromatography

Application of Bis-acetylenic Ketones in Synthesis: One-Pot Preparation of the 1,2,4-Triazepine and Oxatriazaindenone Cores

Bis-acetylenic ketones were used to generate two heterocyclic templates. Two efficient one-pot procedures for the preparation of the triazepine and oxa-triazaindenone cores are described

Epoxidation of Alkenes by Amine Catalyst Precursors: Implication of Aminium Ion and Radical Cation Intermediates

Epoxidation of Alkenes by Amine Catalyst Precursors:  Implication of Aminium Ion and Radical Cation Intermediate