Additional file 1 of The efficacy of DNA mismatch repair enzyme immunohistochemistry as a screening test for hypermutated gliomas

Additional file 1: Table S1. Detailed clinical and pathologic data for the full cohort of 100 gliomas. Tumors 1–9 are hypermutated and are also shown in Table S1. of the main manuscript. The following tumors are from the same patients: 1 and 2; 5, 11, and 12; 7 and 94. Pre-TMZ gliomas were designated as N/A in the TMZ dose and duration columns. Records on temozolomide dosage and cycles were incomplete for many post-TMZ patients, because they had been treated at outside institutions prior to re-resection at Northwestern. “D Astro” = diffuse astrocytoma; “A Astro” = anaplastic astrocytoma; “A Oligo” = anaplastic oligodendroglioma; N/A = not available or not applicable. Table S2. Correlation matrix. N = 93 tumors (cases without MGMT data were excluded, as well as hypermutated tumor #2 since it came from the same patient as tumor #1, see Fig. 2 and Additional file 1: Table S1). Each value represents Spearman ρ (rho) correlation coefficients, with 1 = perfect direct correlation, 0 = no correlation, and − 1 = perfect inverse correlation. *P < 0.05. TMZ = temozolomide