Manhattan plot for obstructive sleep apnea in the European ancestry population.

<p>This figure plots the association results for all SNPs against an apnea hypopnea index of 15 or greater among those of European ancestry. The y-axis displays the -log(p-value), the x-axis the SNP position on each chromosome. The dotted line represents the threshold for statistical significance based on the number of independent comparisons being made.</p

Characteristics of the Study Participants.

<p>Values displayed are means ± standard deviation or median (interquartile range) for continuous variables and percentages for dichotomous variables. OSA is defined as an AHI≥15 for ARIC, FHS, CFS, and WASHS, based on an AHI≥5 plus clinical symptoms for CSA, and based on physician diagnosis for CTRECCPS.</p><p>AHI: apnea hypopnea index; BMI: body mass index; OSA: obstructive sleep apnea.</p

SNPs associated with OSA.

*<p>Heterozygosity P-value for European ancestry cohorts and Hardy-Weinberg P-value for African-Americans.</p

SNPs associated with AHI.

<p>SNPs associated with AHI.</p

Manhattan plot for apnea hypopnea index in African-Americans.

<p>This figure plots the association results for all SNPs against log(apnea hypopnea index +1) among African-Americans. The y-axis displays the -log(p-value), the x-axis the SNP position on each chromosome. The dotted line represents the threshold for statistical significance based on the number of independent comparisons being made.</p

Manhattan plot for apnea hypopnea index in the European ancestry population.

<p>This figure plots the association results for all SNPs against log(apnea hypopnea index +1) among those of European ancestry. The y-axis displays the -log(p-value), the x-axis the SNP position on each chromosome. The dotted line represents the threshold for statistical significance based on the number of independent comparisons being made.</p

Baseline characteristics of cohort studies included in the meta-analysis^*.

<p><i>Definition of abbreviations</i>: ARIC  =  Atherosclerosis Risk in Communities; B58C  =  British 1958 Birth Cohort; BHS  =  Busselton Health Study; CARDIA  =  Coronary Artery Risk Development in Young Adults; CHS  =  Cardiovascular Health Study  =  FHS, Framingham Heart Study; Health ABC  =  Health, Aging, and Body Composition; KORA  =  Cooperative Health Research in the Region of Augsburg; LBC1921  =  Lothian Birth Cohort 1921; LBC1936  =  Lothian Birth Cohort 1936; PIVUS  =  Prospective Investigation of the Vasculature in Uppsala Seniors; RS  =  Rotterdam Study; SAPALDIA  =  Swiss Study on Air Pollution and Lung Diseases in Adults; SD  =  standard deviation; SHIP  =  Study of Health in Pomerania.</p><p>^*Data are presented as mean (SD) unless otherwise indicated; total no. participants  =  27,249, total no. FEV₁ measurements  =  62,130.</p>†<p>Pack-years are calculated among current and former smokers at study baseline.</p

Association of the most statistically significant SNPs with the rate of change in FEV₁ (mL/year) in the meta-analysis of the five cohort studies with ≥3 FEV₁ measurements per participant (n = 10,476).

<p><i>Definition of abbreviations</i>: Chr  =  chromosome; SE  =  standard error; SNP  =  single-nucleotide polymorphism.</p><p>^*Data reported are the meta-analysis results of the SNP-by-time interaction term from the GWAS mixed effects model. A positive β-coefficient indicates an attenuation of FEV₁ decline and a negative β-coefficient an acceleration of FEV₁ decline.</p

Association of the most statistically significant SNPs with the rate of change in FEV₁ (mL/year) in the meta-analysis of 14 cohort studies (n = 27,249)^*.

<p><i>Definition of abbreviations</i>: Chr  =  chromosome; SE  =  standard error; SNP  =  single-nucleotide polymorphism.</p><p>^*Data reported are the meta-analysis results of the SNP-by-time interaction term from the GWAS mixed effects model. A positive β-coefficient indicates an attenuation of FEV₁ decline and a negative β-coefficient an acceleration of FEV₁ decline.</p

Association of the chromosome 11 locus with the rate of change in FEV₁ in the meta-analysis of the five cohort studies with ≥3 FEV₁ measurements per participant.

<p><b>A</b>) Regional association plot, where the X-axis is Megabase (Mb) position, and the Y-axes are the negative log of the <i>P</i> value on the left and recombination rate on the right. The sentinel SNP is colored in purple and linkage disequilibrium to the sentinel SNP is depicted by degree of color according to the legend. <b>B</b>) Forest plot for rs507211, where the size of the square for each study represents its contributing weight to the meta-analysis.</p