Results for <i>CACNA1C</i> SNP rs1006737 (AA+AG>GG) effect on amygdala activation in a sample of bipolar disorder and schizophrenia cases and healthy controls.

<p>Abbreviations: BD, bipolar disorder; SZ, schizophrenia; CTR, healthy controls; FWE, Family-wise error rate; n.s., non-significant.</p><p>Only nominally significant results (Nominal P = <0.05) are shown.</p

Increased amygdala activity in <i>CACNA1C</i> SNP rs1006737 risk allele carriers.

<p>Carriers of the <i>CACNA1C</i> SNP rs1006737 risk allele A have significantly increased activity in the left amygdala in the total sample (x = −24, y = −2, z = −14; FWE P = 0.026) and BD subgroup (x = −24, y = 0, z = −14; FWE P = 0.041), and non-significantly increased activity in the right amygdala in the total sample (x = 26, y = 0, z = −16) and BD subgroup (x = 22, y = 0, z = −20) compared with GG homozygotes during a negative faces paradigm. Abbreviations: BD, bipolar disorder; FWE, family-wise error. Threshold for significance in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056970#pone-0056970-g001" target="_blank">Figure 1</a> is set to Nominal P<0.05 within the ROI.</p

Demographic data and clinical characterization of individuals participating in a faces matching functional MRI study.

<p>Abbreviations: BD, bipolar disorder; HC, healthy controls; SD, standard deviation; WASI, Wechsler Abbreviated Scale of Intelligence; IDS, Inventory of Depressive Symptoms; YMRS, Young Mania Rating Scale; PANSS P score, Positive and Negative Syndrome Scale positive subscale; GAF-S, Global Assessment of Functioning–symptom score; GAF-F, Global Assessment of Functioning–function score; BD PGRS, bipolar disorder polygenic risk score; ms, milliseconds.</p><p>BD PGRS values are reported as z-scores (with SD in brackets).</p><p>Complete behavioral data (response times and accuracy rates per condition) were available for 80/85 BD and 119/121 HC. For the remaining individuals (5 BD, 2 HC), an accuracy rate for each session (i.e. a combined rate for negative faces and shapes, and for positive faces and shapes) was available and was used to confirm that the participants paid attention to the task (accuracy rate: 97.4% and 96.0%, respectively).</p><p>^a Mean age at fMRI scanning. Age range was 18 to 63.</p><p>^b IDS score at scanning was available for 60/85 individuals (70.6%).</p><p>^c YMRS score at scanning was available for 69/85 individuals (81.2%).</p><p>^d PANSS P score at scanning was available for 38/85 individuals (44.7%).</p><p>^e Last six months</p><p>Demographic data and clinical characterization of individuals participating in a faces matching functional MRI study.</p

Bipolar disorder polygenic risk score is positively correlated with BOLD activation in the right inferior frontal gyrus in the entire sample (N = 206) including bipolar disorder cases and healthy controls for the Negative Faces > Shapes contrast.

<p>Color bar indicates z values. Coordinates are given in MNI space. Y = 18 (coronal view), Z = 12 (transversal view). Abbreviations: R, right; A, anterior.</p

Significant clusters at whole-brain level for diagnostic category and polygenic risk score analyses, corrected for sex and age.

<p>*Remains significant after Bonferroni correction (8 independent tests)</p><p>^#P < 0.05 with IQ and education in model</p><p>Abbrevations: Pos, Positive; Neg, Negative; HC, healthy controls; BD, bipolar disorder; PGRS, polygenic risk score; L, left; R, right. ‘+’, positively associated; ‘-’, negatively associated.</p><p>Coordinates are given in MNS space.</p><p>Significant clusters at whole-brain level for diagnostic category and polygenic risk score analyses, corrected for sex and age.</p

Polygenic overlap between depression (DEP) and systolic blood pressure (DEP)(DEP|SBP).

Conditional q-q plot of nominal versus empirical–log 10p values (corrected for inflation) in primary trait (DEP) below the standard GWAS threshold of p (TIF)</p

Polygenic overlap between low-density lipoprotein and depression (LDL) (LDL|DEP).

Conditional q-q plot of nominal versus empirical–log 10p values (corrected for inflation) in primary trait (LDL) below the standard GWAS threshold of p (TIF)</p

Mixer results for depression (DEP) and c-reactive protein (CRP).

(TIF)</p

Zoom plot for DEP and TC centered on the variant rs174594, close to the Fatty Acid Desaturase 2 (<i>FADS2</i>) gene.

This leadSNP was in common for depression, HDL, LDL, TC and TG. (TIF)</p

ConjFDR Manhattan plot.

Common genetic variants both associated with depression (DEP) and high-density lipoprotein (HDL) at conjunctional false discovery rate (conjFDR) 2.0). Independent lead SNPs are encircled in black. The significant shared signal in the major histocompatibility complex region (chr6:25119106–33854733) is represented by one independent lead SNP. (TIF)</p