Additional file 1 of Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injury

Additional file 1. Supplementary figures and tables

Additional file 1 of Glycemic control is independently associated with rapid progression of coronary atherosclerosis in the absence of a baseline coronary plaque burden: a retrospective case–control study from the PARADIGM registry

Additional file 1: Table S1 Comparison of the annual plaque volume changes for each coronary plaque subtype according to statin use Additional file 2: Table S2 Association of the serum hemoglobin A1C level (per 1% increase) with the annual plaque volume changes for each coronary plaque subtype Additional file 3: Table S3 Univariate logistic regression analysis for the associations of clinical variables with the risk of RP

Incident MACE rates for matched patients with versus without MetS.

<p>^a MetS = metabolic syndrome</p><p>^b MACE = major adverse cardiac events</p><p>Incident MACE rates for matched patients with versus without MetS.</p

Hazards ratios for incident MACE for patients with versus without MetS.

<p>^a MetS = metabolic syndrome</p><p>^bMI = myocardial infarction</p><p>^cCI = confidence interval</p><p>Hazards ratios for incident MACE for patients with versus without MetS.</p

Comparison of prevalence, extent and severity of coronary artery disease in matched individuals with versus without MetS based on number of individual components of MetS.

<p>^a VD = vessel disease</p><p>^b LM = left main</p><p>^c MetS = metabolic syndrome</p><p>Comparison of prevalence, extent and severity of coronary artery disease in matched individuals with versus without MetS based on number of individual components of MetS.</p

Flow diagram for patient enrollment.

A total of 8,016 patients met the inclusion criteria.</p

Baseline characteristics by CAC or SIS categories.

Baseline characteristics by CAC or SIS categories.</p

Baseline characteristics.

Baseline characteristics.</p

Baseline characteristics of matched individuals with MetS versus those with individual components of MetS.

<p>^a MetS = metabolic syndrome</p><p>^b BMI = body mass index</p><p>*Matched variables</p><p>Baseline characteristics of matched individuals with MetS versus those with individual components of MetS.</p

Sex-Specific Association of Myocardial Fibrosis With Mortality in Patients With Aortic Stenosis

ImportanceMyocardial fibrosis in aortic stenosis (AS) may exhibit sex differences. However, its prognostic significance in women with AS remains unclear.ObjectiveTo investigate sex differences in myocardial fibrosis assessed by cardiovascular magnetic resonance (CMR) and evaluate its prognostic value in women and men with AS.Design, Setting, and ParticipantsPatients with severe AS who underwent CMR before aortic valve replacement (AVR) were prospectively enrolled from 13 international sites between March 2011 and September 2021. Myocardial fibrosis was evaluated using extracellular volume fraction (ECV%) and late gadolinium enhancement (LGE). The main analysis was conducted on patients without obstructive coronary artery disease (CAD), defined as those with no history of myocardial infarction and no concomitant coronary artery bypass grafting. Data were analyzed from December 2023 to February 2024.ExposuresSurgical or transcatheter AVR.Main Outcomes and MeasuresThe primary outcome was post–AVR all-cause mortality and the secondary outcome was cardiovascular mortality.ResultsOf 822 patients, 670 were without obstructive CAD (368 men [55%] and 302 women [45%]). Among these, women and men had a similar age (median, 72 years vs 71 years, respectively), comorbidities, and AS severity. ECV% was similar between sexes; however, women had less LGE (both infarct and noninfarct LGE). After a median follow-up of 3.7 (IQR, 2.1-4.7) years, there were 76 deaths (11.3%), including 29 adjudicated cardiovascular deaths, in patients without obstructive CAD. Increasing ECV% and LGE were associated with higher all-cause and cardiovascular mortality in both sexes. Cox analyses demonstrated that both ECV% and LGE were associated with higher all-cause mortality without significant interaction by sex (women: adjusted hazard ratio [HR], 1.08 per 1% ECV% increase; 95% CI, 1.04-1.12; P </p