The reproducibility of the allele frequency estimates is shown by the scatter plot of repeated estimates of allele frequency inferred from pooled DNA samples (left)

<p><b>Copyright information:</b></p><p>Taken from "A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples"</p><p>http://www.biomedcentral.com/1471-2156/9/6</p><p>BMC Genetics 2008;9():6-6.</p><p>Published online 14 Jan 2008</p><p>PMCID:PMC2248205.</p><p></p> The labels "run 1" and "run 2" in the x- and y-axis specify each replication. The accuracy of the allele frequency estimates is shown by the scatter plot of the estimates of allele frequency inferred from pooled DNA samples (y-axis in the right plots) and those computed from individually genotyped samples (x-axis). The analysis of the other chromosomes shows similar results

Relation between the pattern of LD (x-axis) and the global measure of association (y-axis) in the regional filter

<p><b>Copyright information:</b></p><p>Taken from "A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples"</p><p>http://www.biomedcentral.com/1471-2156/9/6</p><p>BMC Genetics 2008;9():6-6.</p><p>Published online 14 Jan 2008</p><p>PMCID:PMC2248205.</p><p></p> The pattern of LD is measured by the average of the Bayes D' between consecutive SNPs in the region, and the global measure of association is the joint probability of association in the region. The two figures in the top half show the relation using data from the study of fetal hemoglobin in the sickle cell anemia subjects. The two figure in the bottom half show the relation using data from the longevity study. The different extent of LD reflect the fact that sickle cell anemia subjects are all African American while centenarians in the longevity study are all Caucasians The correlations in the four sets are 0.03, 0.18, 0.018, -0.10