Dynamical Coarse-Graining of Highly Fluctuating Membranes under Shear Flow

The effect of strong shear flow on highly fluctuating lamellar systems stabilized by intermembrane collisions via the Helfrich interaction is studied. Advection enters the microscopic equation of motion for a single membrane via a non-linear coupling. Upon coarse-graining the theory for a single bilayer up to the length scale of the collision length, at which a hydrodynamic description applies, an additional dynamical coupling is generated which is of the form of a wavevector-dependent tension that is non-linear in the applied shear rate. This new term has consequences for the effects of strong flow on the stability and dynamics of lamellar surfactant phases.Comment: 17 pages, 6 figure, submitted to Phys Rev

The Effect of Shear Flow on the Helfrich Interaction in Lyotropic Lamellar Systems

We study the effect of shear flow on the entropic Helfrich interaction in lyotropic surfactant smectic fluids. Arguing that flow induces an effective anisotropic surface tension in bilayers due to a combination of intermonolayer friction, bilayer collisions and convection, we calculate the reduction in fluctuations and hence the renormalised change in effective compression modulus and steady-state layer spacing. We demonstrate that non-permeable or slowly permeating membranes can be susceptible to a undulatory instability of the Helfrich-Hurault type, and speculate that such an instability could be one source of a transition to multilamellar vesicles.Comment: 14 pages, to appear in Eur Phys J

NICMOS and VLBA observations of the gravitational lens system B1933+503

NICMOS observations of the complex gravitational lens system B1933+503 reveal infrared counterparts to two of the inverted spectrum radio images. The infrared images have arc-like structures. The corresponding radio images are also detected in a VLBA map made at 1.7 GHz with a resolution of 6 mas. We fail to detect two of the four inverted radio spectrum components with the VLBA even though they are clearly visible in a MERLIN map at the same frequency at a different epoch. The absence of these two components could be due to rapid variability on a time-scale less than the time delay, or to broadening of the images during propagation of the radio waves through the ISM of the lensing galaxy to an extent that they fall below the surface brightness detectability threshold of the VLBA observations. The failure to detect the same two images with NICMOS is probably due to extinction in the ISM of the lensing galaxy.Comment: 5 pages, 4 figures, submitted to MNRA

Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth?

BACKGROUND: Raised activity of the renin-angiotensin system (RAS) may both amplify inflammatory and free radical responses and decrease tissue metabolic efficiency and thus enhance cerebral injury in the preterm infant. The angiotensin-converting enzyme (ACE) DD genotype is associated with raised ACE and RAS activity as well as potentially adverse stimuli such as inflammation. The DD genotype has been associated with neurological impairments in the elderly, and thus may be also associated with poorer motor or cognitive development amongst children born preterm prematurely. METHODS: The association of DD genotype with developmental progress amongst 176 Caucasian children born at less than 33 weeks gestation (median birthweight 1475 g, range 645–2480 g; gestation 30 weeks, range 22–32; 108 male) was examined at 2 and 5 1/2 years of age. Measured neuro-cognitive outcomes were cranial ultrasound abnormalities, cerebral palsy, disability, Griffiths Developmental Quotient [DQ] at 2 yrs, and General Cognitive Ability [British Ability Scales-11] and motor performance [ABC Movement], both performed at 5 1/2 yrs. All outcomes were correlated with ACE genotype. RESULTS: The DD genotype was not associated with lower developmental quotients even after accounting for important social variables. CONCLUSION: These data do not support either a role for ACE in the development of cognitive or motor function in surviving infants born preterm or inhibition of ACE as a neuroprotective therapy

CFHT AO Imaging of the CLASS Gravitational Lens System B1359+154

We present adaptive optics imaging of the CLASS gravitational lens system B1359+154 obtained with the Canada-France-Hawaii Telescope (CFHT) in the infrared K band. The observations show at least three brightness peaks within the ring of lensed images, which we identify as emission from multiple lensing galaxies. The results confirm the suspected compound nature of the lens, as deduced from preliminary mass modeling. The detection of several additional nearby galaxies suggests that B1359+154 is lensed by the compact core of a small galaxy group. We attempted to produce an updated lens model based on the CFHT observations and new 5-GHz radio data obtained with the MERLIN array, but there are too few constraints to construct a realistic model at this time. The uncertainties inherent with modeling compound lenses make B1359+154 a challenging target for Hubble constant determination through the measurement of differential time delays. However, time delays will offer additional constraints to help pin down the mass model. This lens system therefore presents a unique opportunity to directly measure the mass distribution of a galaxy group at intermediate redshift.Comment: 12 pages including 3 figures; ApJL accepte

Redshifts of CLASS Radio Sources

Spectroscopic observations of a sample of 42 flat-spectrum radio sources from the Cosmic Lens All-Sky Survey (CLASS) have yielded a mean redshift of $= 1.27$ with an RMS spread of 0.95, at a completeness level of 64%. The sample consists of sources with a 5-GHz flux density of 25-50 mJy, making it the faintest flat-spectrum radio sample for which the redshift distribution has been studied. The spectra, obtained with the Willam Herschel Telescope (WHT), consist mainly of broad-line quasars at $z>1$ and narrow-line galaxies at $z<0.5$. Though the mean redshift of flat-spectrum radio sources exhibits little variation over more than two orders of magnitude in radio flux density, there is evidence for a decreasing fraction of quasars at weaker flux levels. In this paper we present the results of our spectroscopic observations, and discuss the implications for constraining cosmological parameters with statistical analyses of the CLASS survey.Comment: 10 pages, AJ accepte

Prevalence and risk factors for mast cell tumours in dogs in England

BACKGROUND: Mast cell tumour (MCT) appears to be a frequent tumour type in dogs, though there is little published in relation to its frequency in dogs in the UK. The current study aimed to investigate prevalence and risk factors for MCTs in dogs attending English primary-care veterinary practices. METHODS: Electronic patient records from practices participating in the VetCompass animal surveillance project between July 2007 and June 2013 were searched for MCT diagnosis. Various search terms and standard diagnostic terms (VeNom codes) identified records containing MCT diagnoses, which were evaluated against clinical criteria for inclusion to the study. MCT prevalence for the entire dataset and specific breed types were calculated. Descriptive statistics characterised MCT cases and multivariable logistic regression methods evaluated risk factors for association with MCT (P < 0.05). RESULTS: Within a population of 168,636 dogs, 453 had MCT, yielding a prevalence of 0.27% (95% confidence interval (CI) 0.24% - 0.29%). The highest breed type specific prevalences were for the Boxer at 1.95% (95% CI 1.40% - 2.51%), Golden Retriever at 1.39% (0.98% - 1.81%) and Weimaraner at 0.85% (95% CI 0.17% to 1.53%). Age, insurance status, neuter status, weight and breed type were associated with MCT diagnosis. Of dogs of specific breed type, the Boxer, Pug and Staffordshire Bull Terrier showed greater odds of MCT diagnosis compared with crossbred dogs. Conversely, the German Shepherd Dog, Border Collie, West Highland White Terrier, Springer Spaniel and Cocker Spaniel had reduced odds of MCT diagnosis compared with crossbred dogs. No association was found between MCT diagnosis and sex. CLINICAL SIGNIFICANCE: This study highlights a clinically significant prevalence of MCT and identifies specific breed types with predisposition to MCT, potentially aiding veterinarian awareness and facilitating diagnosis

Lensing galaxies: light or dark?

In a recent paper, Hawkins (1997) argues on the basis of statistical studies of double-image gravitational lenses and lens candidates that a large population of dark lenses exists and that these outnumber galaxies with more normal mass-to-light ratios by a factor of 3:1. If correct, this is a very important result for many areas of astronomy including galaxy formation and cosmology. In this paper we discuss our new radio-selected gravitational lens sample, JVAS/CLASS, in order to test and constrain this proposition. We have obtained ground-based and HST images of all multiple-image lens systems in our sample and in 12 cases out of 12 we find the lensing galaxies in the optical and/or near infrared. Our success in finding lensing galaxies creates problems for the dark lens hypothesis. If it is to survive, ad hoc modifications seem to be necessary: only very massive galaxies (more than about one trillion solar masses) can be dark, and the cutoff in mass must be sharp. Our finding of lens galaxies in all the JVAS/CLASS systems is complementary evidence which supports the conclusion of Kochanek et al. (1997) that many of the wide-separation optically-selected pairs are physically distinct quasars rather than gravitational lens systems.Comment: 4 pages, 2 included figures, accepted for publication in Astronomy and Astrophysics. Paper version available on request. This replacement amends the text to allow more discussion of the overlap with astro-ph/971016

Gravitational lensing statistics with extragalactic surveys. II. Analysis of the Jodrell Bank-VLA Astrometric Survey

We present constraints on the cosmological constant $\lambda_{0}$ from gravitational lensing statistics of the Jodrell Bank-VLA Astrometric Survey (JVAS). Although this is the largest gravitational lens survey which has been analysed, cosmological constraints are only comparable to those from optical surveys. This is due to the fact that the median source redshifts of JVAS are lower, which leads to both relatively fewer lenses in the survey and a weaker dependence on the cosmological parameters. Although more approximations have to be made than is the case for optical surveys, the consistency of the results with those from optical gravitational lens surveys and other cosmological tests indicate that this is not a major source of uncertainty in the results. However, joint constraints from a combination of radio and optical data are much tighter. Thus, a similar analysis of the much larger Cosmic Lens All-Sky Survey should provide even tighter constraints on the cosmological constant, especially when combined with data from optical lens surveys. At 95% confidence, our lower and upper limits on $\lambda_{0}-\Omega_{0}$, using the JVAS lensing statistics information alone, are respectively -2.69 and 0.68. For a flat universe, these correspond to lower and upper limits on \lambda_{0} of respectively -0.85 and 0.84. Using the combination of JVAS lensing statistics and lensing statistics from the literature as discussed in Quast & Helbig (Paper I) the corresponding $\lambda_{0}-\Omega_{0}$ values are -1.78 and 0.27. For a flat universe, these correspond to lower and upper limits on $\lambda_{0}$ of respectively -0.39 and 0.64.Comment: LaTeX, 9 pages, 18 PostScript files in 6 figures. Paper version available on request. Data available from http://gladia.astro.rug.nl:8000/ceres/data_from_papers/papers.htm