Additional file 1: of Miglustat in Niemann-Pick disease type C patients: a review

Table S1. Comparison of disability scales. (DOCX 45 kb

APY766120_Appendix – Supplemental material for Huntington’s disease: Managing neuropsychiatric symptoms in Huntington’s disease

<p>Supplemental material, APY766120_Appendix for Huntington’s disease: Managing neuropsychiatric symptoms in Huntington’s disease by Samantha M Loi, Mark Walterfang, Dennis Velakoulis and Jeffrey CL Looi in Australasian Psychiatry</p

Systematic review of psychiatric signs in Niemann-Pick disease type C

<p><b>Objectives:</b> We conducted the first systematic literature review and analysis of psychiatric manifestations in Niemann-Pick disease type C (NPC) to describe: (1) time of occurrence of psychiatric manifestations relative to other disease manifestations; and (2) frequent combinations of psychiatric, neurological and visceral disease manifestations.</p> <p><b>Methods:</b> A systematic <i>EMBase</i> literature search was conducted to identify, collate and analyze published data from patients with NPC associated with psychiatric symptoms, published between January 1967 and November 2015.</p> <p><b>Results:</b> Of 152 identified publications 40 were included after screening that contained useable data from 58 NPC patients (mean [SD] age at diagnosis of NPC 27.8 [15.1] years). Among patients with available data, cognitive, memory and instrumental impairments were most frequent (90% of patients), followed by psychosis (62%), altered behavior (52%) and mood disorders (38%). Psychiatric manifestations were reported before or at neurological disease onset in 41 (76%) patients; organic signs (e.g., hepatosplenomegaly, hearing problems) were reported before psychiatric manifestations in 12 (22%). Substantial delays to diagnosis were observed (5–6 years between psychiatric presentation and NPC diagnosis).</p> <p><b>Conclusions:</b> NPC should be considered as a possible cause of psychiatric manifestations in patients with an atypical disease course, acute-onset psychosis, treatment failure, and/or certain combinations of psychiatric/neurological/visceral symptoms.</p

SACCADIC EYE MOVEMENT CHARACTERISTICS IN ADULT NIEMANN-PICK TYPE C DISEASE: RELATIONSHIPS WITH DISEASE SEVERITY AND BRAIN STRUCTURAL MEASURES

SACCADIC EYE MOVEMENT CHARACTERISTICS IN ADULT NIEMANN-PICK TYPE C DISEASE: RELATIONSHIPS WITH DISEASE SEVERITY AND BRAIN STRUCTURAL MEASURE

Size and shape alterations to the corpus callosum in bipolar affective disorder

Size and shape alterations to the corpus callosum in bipolar affective disorde

Morphology of the corpus callosum at different stages of schizophrenia: cross-sectional study in first-episode and chronic illness (vol 192, pg 429, 2008)

Morphology of the corpus callosum at different stages of schizophrenia: cross-sectional study in first-episode and chronic illness (vol 192, pg 429, 2008

STRUCTURE OF THE CORPUS CALLOSUM IN MAJOR AFFECTIVE DISORDERS

STRUCTURE OF THE CORPUS CALLOSUM IN MAJOR AFFECTIVE DISORDER

Shape analysis of thalamus in PD compared to Controls.

Displayed are superior and inferior views of bilateral thalami overlaid on axial MNI T1 0.5mm images. Warmer colors indicate regions of greater inflation in the PD group compared to Controls using point-wise significance tests (p < 0.05, uncorrected). No regions were significant after false-discovery rate correction.</p

Demographic and clinical characteristics of participants.

Demographic and clinical characteristics of participants.</p

Regions showing functional connectivity differences with the MD/A thalamus in PD.

Regions showing functional connectivity differences with the MD/A thalamus in PD.</p