Prevalence of detected hypertension in primary care at practice level, standardised to the RCGP RSC cohort.

Prevalence of detected hypertension in primary care at practice level, standardised to the RCGP RSC cohort.</p

Prevalence of uncontrolled hypertension in primary care at practice level, standardised to the RCGP RSC cohort.

Prevalence of uncontrolled hypertension in primary care at practice level, standardised to the RCGP RSC cohort.</p

Sensitivity analysis—Uncontrolled hypertension in primary care at practice level excluding patients in whom tighter blood pressure targets are recommended, standardised to the RCGP RSC cohort.

Sensitivity analysis—Uncontrolled hypertension in primary care at practice level excluding patients in whom tighter blood pressure targets are recommended, standardised to the RCGP RSC cohort.</p

Sensitivity analysis—Uncontrolled hypertension in primary care at practice level in adults with diagnosed hypertension and a blood pressure reading at any time post diagnosis, standardised to the RCGP RSC cohort.

Sensitivity analysis—Uncontrolled hypertension in primary care at practice level in adults with diagnosed hypertension and a blood pressure reading at any time post diagnosis, standardised to the RCGP RSC cohort.</p

Blood pressure targets in England–(i) NICE National Evidence based Guidance (EBG) and (ii) UK Pay for Performance (PFP) targets.

Blood pressure targets in England–(i) NICE National Evidence based Guidance (EBG) and (ii) UK Pay for Performance (PFP) targets.</p

Study inclusions and exclusions.

Study inclusions and exclusions.</p

Individual and practice level characteristics associated uncontrolled hypertension adjusted for age, sex, ethnicity, deprivation, co-morbidity, obesity, hypertension prescription, practice size and practice location.

Individual and practice level characteristics associated uncontrolled hypertension adjusted for age, sex, ethnicity, deprivation, co-morbidity, obesity, hypertension prescription, practice size and practice location.</p

Supplementary Figures from Trophic distribution of nutrient production in coral reef fisheries

Coral reef fisheries supply nutritious catch to tropical coastal communities, where the quality of reef seafood is determined by both the rate of biomass production and nutritional value of reef fishes. Yet our understanding of reef fisheries typically uses targets of total reef fish biomass rather than individual growth (i.e. biomass production) and nutrient (i.e. nutritional value of reef fish), limiting the ability of management to sustain the productivity of nutritious catches. Here, we use modelled growth coefficients and nutrient concentrations to develop a new metric of nutrient productivity of coral reef fishes. We then evaluate this metric with underwater visual surveys of reef fish assemblages from four tropical countries to examine nutrient productivity of reef fish food webs. Species' growth coefficients were associated with nutrients that vary with body size (calcium, iron, selenium and zinc), but not total nutrient density. When integrated with fish abundance data, we find that herbivorous species typically dominate standing biomass, biomass turnover and nutrient production on coral reefs. Such bottom-heavy trophic distributions of nutrients were consistent across gradients of fishing pressure and benthic composition. We conclude that management restrictions that promote sustainability of herbivores and other low trophic-level species can sustain biomass and nutrient production from reef fisheries that is critical to the food security of over 500 million people in the tropics

Data_Sheet_1_A cohort study of circulating progenitor cells after ST-segment elevation and non-ST segment elevation myocardial infarction in non-diabetic and diabetic patients.PDF

BackgroundMyocardial infarction induces elevation of progenitor cells in the circulation, a reparative response inhibited by type-2 diabetes.ObjectivesDetermine if myocardial infarct severity and diabetes interactively influence the migratory activity of CD34+/CXCR4+ progenitor cells and if the migratory test predicts cardiac outcomes.Materials and methodsA longitudinal study was conducted on patients with or without diabetes with a STEMI or NSTEMI. CD34+/CXCR4+ cells were measured in the peripheral blood using flow cytometry, and migratory activity was tested in vitro on cells isolated from samples collected on days 0 and 4 post-infarct. Cardiac function was assessed at three months using cardiac MRI.ResultsOf 1,149 patients screened, 71 (6.3%) were eligible and consented. Fifty had STEMI (16 with diabetes) and 21 NSTEMI (8 with diabetes). The proportion of CD34+/CXCR4+ cells within blood mononuclear cells was 1.96 times higher after STEMI compared with NSTEMI (GMR = 1.96, 95% CI 0.87, 4.37) and 1.55 times higher in patients with diabetes compared to patients without diabetes (GMR = 1.55, 95% CI 0.77, 3.13). In the latter, STEMI was associated with a 2.42-times higher proportion of migrated CD34 + /CXCR4 + cells compared with NSTEMI (GMR = 2.42, 95% CI 0.66, 8.81). In patients with diabetes, the association was the opposite, with a 55% reduction in the proportion of migrated CD34+/CXCR4+ cells. No statistically significant associations were observed between the frequency in peripheral blood or in vitro migration capacity of CD34+/CXCR4+ cells and MRI outcomes.ConclusionWe document the interaction between infarct and diabetes on the migratory activity of CD34+/CXCR4+ cells. The test did not predict functional outcomes in the studied cohort.</p

Table S1 from Trophic distribution of nutrient production in coral reef fisheries

Mean % contribution of herbivores and piscivores to fishery services in each country, with lower and upper ranges (SEM)