Metabolites discriminating hypercholesterolaemic from normocholesterolaemic samples, according to VIP score values.

Metabolites discriminating hypercholesterolaemic from normocholesterolaemic samples, according to VIP score values.</p

PCA score scatter plot (A) and PCA loading scatter plot (B) for the ¹H NMR data collected in 1D NOESY spectra acquired at 600 MHz.

Data are relative to 14 hypercholesterolaemic (green circles) and 16 normocholesterolaemic (red circles) human sera.</p

Pathway enrichment analysis: The pathways related to a <i>p</i>-value that excludes randomness and correlates with hypercholesterolaemia.

Pathway enrichment analysis: The pathways related to a p-value that excludes randomness and correlates with hypercholesterolaemia.</p

PLS-DA score scatter plot (A) and PLS-DA loading scatter plot (B) for the ¹H NMR data collected in 1D NOESY spectra acquired at 600 MHz.

Data represent 14 hypercholesterolaemic (green circles) and 16 normocholesterolaemic (red circles) human sera.</p

Graph of pathway impact and relative <i>p</i>-value.

Pathway analysis showing all matched pathways according to p-values from pathway enrichment analysis (y-axis) and pathway impact values from pathway topology analysis (x-axis). The colour and size of each circle are based on p-values and pathway impact values, respectively. Small p-values and large pathway impact circles indicate that the pathway is greatly perturbed. The top 5 pathways in order of p-values from the pathway analysis are numbered as follows: 1) pantothenate and CoA biosynthesis, 2) pyruvate metabolism, 3) glycolysis/ gluconeogenesis, 4) citrate cycle (TCA cycle) and 5) synthesis and degradation of ketone bodies.</p