22,543 research outputs found
Sistemas agroflorestais: efeitos na dinâmica de nutrientes e na macrofauna invertebrada da serapilheira.
Sistemas agroflorestais: efeitos na dinâmica de nutrientes e na macrofauna invertebrada da serapilheira; Sistemas agroflorestais: objetivos e benefícios; Serapilheira como fonte de nutrientes nos SAFs; Macrofauna invertebrada como indicador de qualidade do solo.bitstream/item/95222/1/DOC1710001.pd
Estoques de carbono e nutrientes e macrofauna invertebrada em argissolo sob sistemas agroflorestais e agricultura de corte e queima no norte do Piauí.
bitstream/item/83415/1/CT2020001.pd
Programa de cultivo de moluscos bivalves da embrapa Meio-Norte.
bitstream/item/35061/1/Documentos1830001.pd
Boston University Concert Choir and Women's Chorale, October 18, 2003
This is the concert program of the Boston University Concert Choir and Women's Chorale performance on Saturday, October 18, 2003 at 8:00 p.m., at Marsh Chapel, 735 Commonwealth Avenue, Boston, Massachusetts. Works performed were Psalm 150 by David Willcocks, Pslam 13 by Johannes Brahms, Magnificat by Nicola Porpora, Two Settings from Alice in Wonderland by Irving Fine, Confirma hoc Deus by Mikolaj Zielenski, and Chichester Psalms by Leonard Bernstein. Digitization for Boston University Concert Programs was supported by the Boston University Center for the Humanities Library Endowed Fund
Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients
PURPOSE: Deficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error of immunity, characterized by autoinflammation (recurrent fever), vasculopathy (livedo racemosa, polyarteritis nodosa, lacunar ischemic strokes, and intracranial hemorrhages), immunodeficiency, lymphoproliferation, immune cytopenias, and bone marrow failure (BMF). Tumor necrosis factor (TNF-α) blockade is the treatment of choice for the vasculopathy, but often fails to reverse refractory cytopenia. We aimed to study the outcome of hematopoietic cell transplantation (HCT) in patients with DADA2.
METHODS: We conducted a retrospective study on the outcome of HCT in patients with DADA2. The primary outcome was overall survival (OS).
RESULTS: Thirty DADA2 patients from 12 countries received a total of 38 HCTs. The indications for HCT were BMF, immune cytopenia, malignancy, or immunodeficiency. Median age at HCT was 9 years (range: 2-28 years). The conditioning regimens for the final transplants were myeloablative (n = 20), reduced intensity (n = 8), or non-myeloablative (n = 2). Donors were HLA-matched related (n = 4), HLA-matched unrelated (n = 16), HLA-haploidentical (n = 2), or HLA-mismatched unrelated (n = 8). After a median follow-up of 2 years (range: 0.5-16 years), 2-year OS was 97%, and 2-year GvHD-free relapse-free survival was 73%. The hematological and immunological phenotypes resolved, and there were no new vascular events. Plasma ADA2 enzyme activity normalized in 16/17 patients tested. Six patients required more than one HCT.
CONCLUSION: HCT was an effective treatment for DADA2, successfully reversing the refractory cytopenia, as well as the vasculopathy and immunodeficiency.
CLINICAL IMPLICATIONS: HCT is a definitive cure for DADA2 with > 95% survival
Toxicidade induzida pela terapêutica intermitente com Rifampicina: Análise de um caso clínico
SUMMARYWe repport the case of a patient who developed a severe drug-induced hypersensitivity sistemic reaction to Rifampicin, that included a flulike syndrome, severe hemolytic anaemia, renal failure, shock and toxic epidermal necrolysis.Besides the clinical evolution we consider the difficulties in clinical diagnosis and the role of the in vitro laboratory assays
Revisiting Gini for equitable humanitarian logistics
Modeling equity in the allocation of scarce resources is a fast-growing
concern in the humanitarian logistics field. The Gini coefficient is one of the
most widely recognized measures of inequity and it was originally characterized
by means of the Lorenz curve, which is a mathematical function that links the
cumulative share of income to rank-ordered groups in a population. So far,
humanitarian logistics models that have approached equity using the Gini
coefficient do not actually optimize its original formulation, but use
alternative definitions that do not necessarily replicate that original Gini
measure. In this paper, we derive the original Gini coefficient via the Lorenz
curve to optimize the effectiveness-equity trade-off in a humanitarian
location-allocation problem. We also propose new valid inequalities based on an
upper-bounding Lorenz curve to tighten the linear relaxation of our model and
develop a clustering-based construction of the Lorenz curve that requires fewer
additional constraints and variables than the original one. The computational
study, based on the floods and landslides in Rio de Janeiro state, Brazil,
reveals that while alternative Gini definitions have interesting properties,
they can generate vastly different decisions compared to the original Gini
coefficient. In addition, viewed from the perspective of the original Gini
coefficient, these decisions can be significantly less equitable
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