Concordance between the Clinical Definition of Polypathological Patient versus Automated Detection by Means of Combined Identification through ICD-9-CM Codes

It is unknown whether the digital application of automated ICD-9-CM codes recorded in the medical history are useful for a first screening in the detection of polypathological patients. In this study, the objective was to identify the degree of intra- and inter-observer concordance in the identification of in-patient polypathological patients between the standard clinical identification method and a new automatic method, using the basic minimum data set of ICD-9-CM codes in the digital medical history. For this, a cross-sectional multicenter study with 1518 administratively discharged patients from Andalusian hospitals during the period of 2013–2014 has been carried out. For the concordance between the clinical definition of a polypathological patient and the polypathological patient classification according to ICD-9-CM coding, a 0.661 kappa was obtained (95% confidence interval (CI); 0.622–0.701) with p < 0.0001. The intraclass correlation coefficient between both methods for the number of polypathological patient categories was 0.745 (95% CI; 0.721–0.768; p < 0.0001). The values of sensitivity, specificity, positive-, and negative predictive values of the automated detection using ICD-9-CM coding were 78%, 88%, 78%, and 88%, respectively. As conclusion, the automatic identification of polypathological patients by detecting ICD-9-CM codes is useful as a screening method for in-hospital patients.Instituto de Salud Carlos III PI 14/025

Presentación

Se procede a presentar los resultados del proyecto de investigación concedidos por el MICIM bajo el título de "Cerámica y Estilo", que focalizaba su interés en las primeras producciones cerámicas de los grupos neolíticos peninsulares, durante el VI milenio cal AC

A Multi-Criteria Reference Point Based Approach for Assessing Regional Innovation Performance in Spain

[EN] The evaluation of regional innovation performance through composite innovation indices can serve as a valuable tool for policy-making. While discussion on the best methodology to construct composite innovation indices continues, we are interested in deepening the use of reference levels and the aggregation issue. So far, additive aggregation methods are, largely, the most widespread aggregation rule, thus allowing for full compensability among single indicators. In this paper, we present an integrated assessment methodology to evaluate regional innovation performance using the Multi-Reference Point based Weak and Strong Composite Indicator (MRP-WSCI) approach, which allows defining reference levels and different degrees of compensability. As an example of application to the Regional Innovation Scoreboard, the proposed technique is developed to measure the innovation performance of Spain¿s regions taking into account Spanish and European reference levels. The main features of the proposed approach are: (i) absolute or relative reference levels could be previously defined by the decision maker; (ii) by establishing the reference levels, the resulting composite innovation index is an easy-to-interpret measure; and (iii) the non-compensatory strong composite indicator provides an additional layer of information for policy-making (iv) a visualization tool called Light-Diagram is proposed to track the specific strengths and weaknesses of the regions' innovation performance.This research has been partially supported by the Spanish Ministry of Economy and Competitiveness (Project ECO2016-76567-C4-4-R), by the Regional Government of Andalucia (research group SEJ-417), and by the ERDF funds (Project UMA18-FEDERJA-065).Garcia-Bernabeu, A.; Cabello, JM.; Ruiz, F. (2020). A Multi-Criteria Reference Point Based Approach for Assessing Regional Innovation Performance in Spain. 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A survey on elasticity management in PaaS systems

[EN] Elasticity is a goal of cloud computing. An elastic system should manage in an autonomic way its resources, being adaptive to dynamic workloads, allocating additional resources when workload is increased and deallocating resources when workload decreases. PaaS providers should manage resources of customer applications with the aim of converting those applications into elastic services. This survey identifies the requirements that such management imposes on a PaaS provider: autonomy, scalability, adaptivity, SLA awareness, composability and upgradeability. This document delves into the variety of mechanisms that have been proposed to deal with all those requirements. Although there are multiple approaches to address those concerns, providers main goal is maximisation of profits. This compels providers to look for balancing two opposed goals: maximising quality of service and minimising costs. 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A Reference Point-Based Proposal to Build Regional Quality of Life Composite Indicators

[EN] There is a growing interest in research on the role that space plays in defining and measuring well-being or quality of life. In this paper, we propose to evaluate the regional quality of life using the Multi-Reference Point based Weak Strong Composite Indicator approach, to further enhance the quality of the sub-national analysis. The major motivation is to facilitate assessing the regional quality of life performance at different geographical scales and compensability levels. As an example of application, we compute the composite indicators for 19 Spanish regions to paint a comprehensive picture of the regional quality of life using two different geographical scales: the Spanish and the European ones. Moreover, we provide warning signals to regional, national and European policy-makers on the quality of life dimensions in which each region needs further improvements.This research was partially funded by the Spanish Ministry of Economy and Competitiveness (Project PID2019-104263RB-C42), from the Regional Government of Andalucía (Project P18-RT-1566), and by the EU ERDF operative program (Project UMA18-FEDERJA-065)Garcia-Bernabeu, A.; Cabello, JM.; Ruiz, F. (2021). A Reference Point-Based Proposal to Build Regional Quality of Life Composite Indicators. Social Indicators Research (Online). 1-20. https://doi.org/10.1007/s11205-021-02818-0S120Blancas, F., Caballero, R., González, M., Lozano-Oyola, M., & Pérez, F. (2010). Goal programming synthetic indicators: An application for sustainable tourism in andalusian coastal counties. Ecological Economics, 69(11), 2158–2172.Boggia, A., Massei, G., Pace, E., Rocchi, L., Paolotti, L., & Attard, M. (2018). 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Socio-Economic Planning Sciences, 70, 100701.Lagas, P., van Dongen, F., van Rijn, F., & Visser, H. (2015). Regional quality of living in Europe. Region, 2(2), 1–26.Malkina-Pykh, I. G., & Pykh, Y. A. (2008). Quality-of-life indicators at different scales: Theoretical background. Ecological Indicators, 8(6), 854–862.Marchante, A. J., & Ortega, B. (2006). Quality of life and economic convergence across Spanish regions, 1980–2001. Regional Studies, 40(5), 471–483.Mazziotta, M., & Pareto, A. (2016). On a generalized non-compensatory composite index for measuring socio-economic phenomena. Social Indicators Research, 127(3), 983–1003.Mazziotta, M., & Pareto, A. (2020). Composite indices construction: The performance interval approach. Social Indicators Research pp. 1–11.Nardo, M., Saisana, M., Saltelli, A., Tarantola, S., Hoffman, A., & Giovannini, E. (2008). Handbook on constructing composite indicators.OECD: Handbook on constructing composite indicators: methodology and user guide. (2008). 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State-of-the-art report on current methodologies and practices for composite indicator development. Ispra: Joint Research Centre.Stiglitz, J.E., Sen, A., Fitoussi, J.P., et al. (2009). Report by the commission on the measurement of economic performance and social progress

Aumento de dosis génica de los genes DPL1, SSD1 y SRP101 en Saccharomyces cerevisiae y fenotipo de tolerancia a acidificación intracelular

[ES] El pH alto intracelular es una señal promotora del crecimiento y proliferación de las células pero sus mecanismos no son bien conocidos. En un trabajo previo se había identificado una región genómica de levadura que al ser transformada en plásmido de copia simple aumenta el crecimiento de la levadura en condiciones de acidificación intracelular. Esta región contiene tres genes, DPL1, SSD1 y SRP101 y en este trabajo hemos identificado el gen SSD1 como el responsable del fenotipo de pH. Este gen codifica un regulador del crecimiento de la levadura que coopera con otros reguladores importantes como la proteína kinasa TORC1 y la proteína fosfatasa Sit4. El mecanismo de Ssd1 se basa en unir y estabilizar RNA mensajeros de ciclinas y el alelo clonado es la forma activa del gen presente en levaduras silvestres, mientras que las cepas de laboratorio poseen una forma truncada inactiva. Ssd1 también mejora el crecimiento en condiciones normales, sin estrés ácido, en medio con amonio pero no en medio con aminoácidos como fuente de nitrógeno. Como los aminoácidos y el pH alto activan TORC1, podemos sugerir que Ssd1 aumenta la expresión de ciclinas cuando TORC1 no está completamente activado por pH alto o por aminoácidos.[EN] Intracellular pH is a signal promoting cell growth and proliferation by poorly known mechanisms. In previous work, a yeast genomic region was identified that by transformation in single copy plasmid improves yeast growth under conditions of intracellular acidification. This region contains three genes, DPL1, SSD1 and SRP101, and in the present work we have identified SSD1 as the one responsible of the pH phenotype. This gene encodes a regulator of yeast growth that cooperates with other important regulators such as the protein kinase TORC1 and the protein phosphatase Sit4. The mechanism of Ssd1 consists on binding and stabilizing of cyclin mRNAs and the cloned allele is the active form present in wild yeast while laboratory strains express a truncated, inactive form. Ssd1 also improves growth under normal conditions, without pH stress, in media with ammonia but not in media with amino acids as nitrogen source. As amino acids and high pH activate TORC1, it may be suggested that Ssd1 increases cyclin expression when TORC1 is not fully activated by either high pH or amino acidsBernabeu Lorenzo, M. (2015). Aumento de dosis génica de los genes DPL1, SSD1 y SRP101 en Saccharomyces cerevisiae y fenotipo de tolerancia a acidificación intracelular. http://hdl.handle.net/10251/54365.TFG

Automatic parameter tuning for functional regionalization methods

The methods used to define functional regions for public statistics and policy purposes need to establish several parameter values. This is typically achieved using expert knowledge based on qualitative judgements and lengthy consultations with local stakeholders. We propose to support this process by using an optimization algorithm to calibrate any regionalization method by identifying the parameter values that produce the best regionalization for a given quantitative indicator. The approach is exemplified by using a grid search and a genetic algorithm to configure the official methods employed in the UK and Sweden for the definition of their respective official concepts of local labour markets.Los métodos utilizados para definir las regiones funcionales con fines de estadística y políticas públicas deben establecer una serie de valores de ciertos parámetros. Esto se logra generalmente utilizando conocimiento experto basado en juicios cualitativos y largas consultas con las partes interesadas locales. Se propone apoyar este proceso utilizando un algoritmo de optimización para calibrar los métodos de regionalización mediante la identificación de los valores de los parámetros que producen la mejor regionalización para un determinado indicador cuantitativo. El enfoque se ejemplifica mediante el uso de una búsqueda por cuadrículas y un algoritmo genético para configurar los métodos oficiales empleados en el Reino Unido y en Suecia para la definición de sus respectivos conceptos oficiales de los mercados laborales locales.This work was supported by the Spanish Ministry of Economy and Competitiveness (grant numbers CSO2011-29943-C03-02 and CSO2014-55780-C3-2-P, National R&D&i Plan)

The Feminine Section in the vaccination campaigns of the first Francoism: the case of the province of Valencia (1941-1958)

El objetivo del trabajo es analizar la participación de las enfermeras sociales y las divulgadoras rurales de Sección Femenina (S.F.) en las campañas de vacunación del primer franquismo. Material y Métodos: Como principal fuente documental se han utilizado los legajos depositados en el Archivo del Reino de Valencia (A.R.V.), y en concreto los correspondientes a la Sección Femenina Inventario (S.F.I.) (1940-1977). Resultados: las actividades de vacunación en las que participó S.F. fueron poco uniformes y constantes, decrecieron a medida que transcurrían los años, y mostraron importantes desigualdades territoriales. En el intento por superar las resistencias de la población a vacunarse, las enfermeras sociales y divulgadoras rurales desarrollaron actividades de educación sanitaria que estuvieron informadas por el paternalismo asistencial y el adoctrinamiento ideológico de S.F. Conclusiones: el ejemplo de las campañas de vacunación ha puesto de manifiesto las limitaciones y la dificultades que encontró S.F. para alcanzar en la provincia de Valencia sus objetivos socio-sanitarios.The aim of this study was to analyse the participation of health visitors and rural educators belonging to the Women’s Section of the Falange (WS) in vaccination campaigns during the first stage of the Franco regime. Material and Methods: The main source of information consulted was the collection of files deposited in the Archives of the Kingdom of Valencia (Spanish initials: A.R.V), and more specifically, those corresponding to the Inventory of the Women’s Section (1940-1977). Results: the participation of the WS in vaccination campaigns was uneven and sporadic, diminished over the years and presented major regional variations. In an attempt to overcome the population’s resistance to vaccination, health visitors and rural educators implemented health education activities, which were informed by the welfare paternalism and ideological indoctrination of the WS. Conclusions: the example of these vaccination campaigns highlights the limitations and difficulties that the WS encountered in achieving their social and health goals in the province of Valencia

Monitoring and Prevention the Smart Cities

Nowadays, the intensive use of Technology Information (TI) provide solutions to problems of the high population density, energy conservation and cities management. This produces a newest concept of the city, Smart City. But the inclusion of TI in the city brings associated new problems, specifically the generation of electromagnetic fields from the available and new technological infrastructures installed in the city that did not exist before. This new scenario produces a negative effect on a particular group of the society, as are the group of persons with electromagnetic hypersensitivity pathology. In this work we propose a system that would allow you to detect and prevent the continuous exposure to such electromagnetic fields, without the need to include more devices or infrastructure which would only worsen these effects. Through the use of the architecture itself and Smart City services, it is possible to infer the necessary knowledge to know the situation of the EMF radiation and thus allow users to avoid the areas of greatest conflict. This knowledge, not only allows us to get EMF current map of the city, but also allows you to generate predictions and detect future risk situations.This work has been performed within project Smart University funded from the Vice President office for Information Technology at the University of Alicante

Smart Sentinel: Monitoring and Prevention System in the Smart Cities

Today, faced with the constant rise of the Smart cities around the world, there is an exponential increase of the use and deployment of information technologies in the cities. The intensive use of Information Technology (IT) in these ecosystems facilitates and improves the quality of life of citizens, but in these digital communities coexist individuals whose health is affected developing or increasing diseases such as electromagnetic hypersensitivity. In this paper we present a monitoring, detection and prevention system to help this group, through which it is reported the rates of electromagnetic radiation in certain areas, based on the information that the own Smart City gives us. This work provides a perfect platform for the generation of predictive models for detection of future states of risk for humans.This work has been performed within project Smart University funded from the Vice President office for Information Technology at the University of Alicante