DSSA Simulations: Exploring the Effects of <i>P</i>₀

<p>The horizontal dotted line marks <i>P</i>₀, mRNA is represented by the solid line, and protein by the dashed line.</p

DSSA Simulation: Calculating the Arithmetic Mean over 1,000 Simulations for Both Constant and Variable Delay

<p>DSSA Simulation: Calculating the Arithmetic Mean over 1,000 Simulations for Both Constant and Variable Delay</p

Mean Oscillation Frequencies for Different Delay Values (<i>P</i>₀, <i>h</i>, <i>μ_m, μ_p</i> Are Fixed)

<p>Mean Oscillation Frequencies for Different Delay Values (<i>P</i>₀, <i>h</i>, <i>μ_m, μ_p</i> Are Fixed)</p

Sensitivity Analysis: DSSA Simulations with Perturbed Rate Constants

<div><p>(A) <i>α_m</i><b>.</b></p><p>(B) <i>α_p</i><b>.</b></p><p>(C) <i>μ_m</i><b>.</b></p><p>(D) <i>μ_p</i>.</p></div

DDE Solution: Exploring the Effect of Delay on Protein

<p>DDE Solution: Exploring the Effect of Delay on Protein</p

DSSA Simulations: Exploring the Effects of <i>h</i>

<p>The horizontal dotted line marks <i>P</i>₀, mRNA is represented by the solid line, and protein by the dashed line.</p

DSSA Simulations for <i>P</i>₀ = 100, <i>h</i> = 3, <i>τ</i> = 10 (Top) and <i>P</i>₀ = 100, <i>h</i> = 4, <i>τ</i> = 15 (Bottom) over 12 h and 2 h

<p>Left, more than 12 h. Right, more than 2 h. The dotted horizontal line corresponds to <i>P</i>₀. Solid lines represent mRNA, dashed lines protein populations.</p

DSSA Simulation

<div><p>(A) Mimicking blocking of Hes1 protein degradation by a proteasome inhibitor.</p><p>(B) Mimicking inhibition of translation by cycloheximide treatment.</p></div

DDE Solution: Exploring the Effect of <i>h</i> on Protein

<p>DDE Solution: Exploring the Effect of <i>h</i> on Protein</p

DDE Solution: Exploring the Effect of Large <i>P</i>₀

<p>DDE Solution: Exploring the Effect of Large <i>P</i>₀</p