1,794 research outputs found

    Results from the third Scottish National Prevalence Survey: is a population health approach now needed to prevent healthcare-associated infections?

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    Summary Background Healthcare associated infections (HAI) are a major public health concern and a significant cause of morbidity and mortality. A robust and current evidence base that is specific to local, national and Europe-wide settings is necessary to inform the development of strategies to reduce HAI and contain antimicrobial resistance (AMR). Aim To measure the prevalence of HAI and antimicrobial prescribing and identify key priority areas for interventions to reduce the burden of infection. Methods A national rolling PPS in National Health Service (NHS) acute, NHS non-acute, NHS paediatric and independent hospitals was carried out between September and November 2016 using the European Centre for Disease Prevention and Control protocol designed for the European PPS. Findings The prevalence of HAI was 4.6%, 2.7% and 3.2% in acute adults, paediatric and non-acute patient groups, respectively. The most common HAI types reported in adult patients were urinary tract infection and pneumonia. The prevalence of antimicrobial prescribing was 35.7%, 29.3% and 13.8% in acute adults, paediatric and non-acute patient groups, respectively. Respiratory, skin and soft tissue, gastrointestinal and urinary tract infections were the most common infections being treated at the time of survey. Conclusion HAI continues to be a public health concern in Scotland. UTI and pneumonia continue to place a significant burden on patients and on healthcare delivery, including those that develop in the community and require hospital admission. A broader population health approach which focuses on reducing the risk of infection upstream would reduce these infections in both community and hospital settings

    Hybrid vertex-midline modelling of elongated plant organs

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    We describe a method for the simulation of the growth of elongated plant organs, such as seedling roots. By combining a midline representation of the organ on a tissue scale and a vertex-based representation on the cell scale, we obtain a multiscale method, which is able to both simulate organ growth and incorporate cell-scale processes. Equations for the evolution of the midline are obtained, which depend on the cell-wall properties of individual cells through appropriate averages over the vertex-based representation. The evolution of the organ midline is used to deform the cellular-scale representation. This permits the investigation of the regulation of organ growth through the cell-scale transport of the plant hormone auxin. The utility of this method is demonstrated in simulating the early stages of the response of a root to gravity, using a vertex-based template acquired from confocal imaging. Asymmetries in the concentrations of auxin between the upper and lower sides of the root lead to bending of the root midline, reflecting a gravitropic response

    Topological Conformal Gravity in Four Dimensions

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    In this paper, we present a new formulation of topological conformal gravity in four dimensions. Such a theory was first considered by Witten as a possible gravitational counterpart of topological Yang-Mills theory, but several problems left it incomplete. The key in our approach is to realise a theory which describes deformations of conformally self-dual gravitational instantons. We first identify the appropriate elliptic complex which does precisely this. By applying the Atiyah-Singer index theorem, we calculate the number of independent deformations of a given gravitational instanton which preserve its self-duality. We then quantise topological conformal gravity by BRST gauge-fixing, and discover how the quantum theory is naturally described by the above complex. Indeed, it is a process which closely parallels that of the Yang-Mills theory, and we show how the partition function generates an uncanny gravitational analogue of the first Donaldson invariant.Comment: 35 pages, harvmac, DAMTP R92/4

    Public perceptions of, and responses to, desalination in Australia : a report on findings

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    Desalination as a method of ensuring a rainfall independent source of potable water has become an increasingly favourable option for Australian governments, particularly over the last decade or so. This is especially true for metropolitan areas. The social acceptability of new sources of water, however, impacts on the readiness with which publics accept changed or augmented water supplies. Researchers at Deakin University, Victoria University and Murdoch University, with funding from the National Centre of Excellence in Desalination Australia (NCEDA), have conducted a study of public attitudes to desalination in Australia. This report outlines the results of the 18 month project, which comprises three sections. The cornerstone of the project is a national survey (n=3077), conducted by Datacol Research. The second component of the study consists of focus groups in the vicinity of three existing or developing desalination plants: Wonthaggi (Victoria), Port Stanvac (South Australia), and Kwinana (Western Australia). The third component of the study presented in this report involves interviews with desalination scientists and other technical experts, in relation to their attitudes to communication with lay publics

    An investigation into the sample preparation procedure and analysis of cyanoacrylate adhesives using capillary electrophoresis

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    In this study, the trace acid profile of cyanoacrylate adhesives was studied using capillary electrophoresis. Liquid–liquid extraction was employed as the sample preparation step before separation by capillary electrophoresis. The solubility of the adhesives was investigated using various organic solvents, e.g. hexane and dichloromethane, and chloroform was determined to be the optimum solvent as it enabled the full dissolution of the adhesive. A comprehensive stability study was performed over a 3-year period and results indicate that the adhesives were stable for 2 years after which their stability and performance degraded
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