46 research outputs found
Rural regeneration through direct marketing of Audubon County meats
Audubon County Family Farms direct-marketed their farm products through the downtown farmers market in Des Moines. In addition to selling their products, the farmers encouraged dialogue with urban consumers through personal interaction and educational activities
Making the connection—Linking farms to HRIs
Iowa farmers interested in selling their products locally wanted more information about the institutional-type markets for these foods so they could determine how to work with these markets
Marketing and value-added opportunities with alternative swine systems
Cindy Madsen is a member of Audubon County Family Farms, a group of producers who believe in healthy farms raising healthy families. They work together to market their products directly to the consumer. Four producers use hooped structures in their hog production, two\u27sell chickens and eggs, one has antibiotic-free beef, as well as other products. All have very diverse, sustainable farming systems. It helps to have a state-inspected small processor available 20 miles from Audubon.
Gary Malenke of Sioux-Preme Packing shared insights from the packer\u27s perspective. His company\u27s primary business had used mostly frozen carcasses until they began working with Farmland Foods and started to custom cut their own hogs in early 1997. In a constantly changing business, he said Sioux-Preme had trouble establishing an identity in a very competitive primal cuts market. One strategy has been to focus on lighter weight pigs, which work well for food service. To differentiate themselves, they went to customers not being served by the mainstream packers
Development of Transgenic Cloned Pig Models of Skin Inflammation by DNA Transposon-Directed Ectopic Expression of Human β1 and α2 Integrin
Integrins constitute a superfamily of transmembrane signaling receptors that play pivotal roles in cutaneous homeostasis by modulating cell growth and differentiation as well as inflammatory responses in the skin. Subrabasal expression of integrins α2 and/or β1 entails hyperproliferation and aberrant differentiation of keratinocytes and leads to dermal and epidermal influx of activated T-cells. The anatomical and physiological similarities between porcine and human skin make the pig a suitable model for human skin diseases. In efforts to generate a porcine model of cutaneous inflammation, we employed the Sleeping Beauty DNA transposon system for production of transgenic cloned Göttingen minipigs expressing human β1 or α2 integrin under the control of a promoter specific for subrabasal keratinocytes. Using pools of transgenic donor fibroblasts, cloning by somatic cell nuclear transfer was utilized to produce reconstructed embryos that were subsequently transferred to surrogate sows. The resulting pigs were all transgenic and harbored from one to six transgene integrants. Molecular analyses on skin biopsies and cultured keratinocytes showed ectopic expression of the human integrins and localization within the keratinocyte plasma membrane. Markers of perturbed skin homeostasis, including activation of the MAPK pathway, increased expression of the pro-inflammatory cytokine IL-1α, and enhanced expression of the transcription factor c-Fos, were identified in keratinocytes from β1 and α2 integrin-transgenic minipigs, suggesting the induction of a chronic inflammatory phenotype in the skin. Notably, cellular dysregulation obtained by overexpression of either β1 or α2 integrin occurred through different cellular signaling pathways. Our findings mark the creation of the first cloned pig models with molecular markers of skin inflammation. Despite the absence of an overt psoriatic phenotype, these animals may possess increased susceptibility to severe skin damage-induced inflammation and should be of great potential in studies aiming at the development and refinement of topical therapies for cutaneous inflammation including psoriasis
(International) R&D collaboration and SMEs: The effectiveness of targeted public R&D support schemes
Identification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection Mapping
Peer reviewe
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts
Resultatstyring i handelshøyskolen: En kvalitetsutopi?
Studien undersøker hvordan en handelshøyskole vektlegger ulike kvalitetsmål, samt hvordan dette måles og følges opp for å kunne besvare hvilke kvalitetsmål som prioriteres i deres resultatstyring. Oppgaven tegner et bilde av hvordan forståelsen av kvalitetsbegrepet, strategi og mål varierer på ulike nivåer og avdelinger i én organisasjon gjennom å innhente data fra dokumenter og informanter på flere nivåer og campus i Handelshøgskolen i Tromsø.
Sentrale teorier er translasjonsteori av Røvik (1998; 2007), Harvey & Greens (1993) definisjon av kvalitet og prinspal-agentteori (Douma & Schreuder, 2013; Jensen & Meckling, 1976).
Hovedfunn i studien viser blant annet at de ulike nivåene gjør radikale oversettelser og kan velge bort og legge til målsetninger basert på Kunnskapsdepartementets sektormål og styringsparametere, at både måleindikatorer og insentiver for arbeid med undervisningskvalitet er svake, og at særlig akademisk ansatte mener enkelte kvalitetsmål underprioriteres. Høyere nivåene definerer kvalitet og satsningsområder bredere enn de lavere nivåene i organisasjonen.
Funnene impliserer at det eksisterer en målforskyvning hvor vektlegging av mer kvantifiserbare kvalitetsmål prioriteres.
Nøkkelord: Universiteter og høyskoler, Resultatstyring, Offentlige organisasjoner, oversettelser.
Making the connection—Linking farms to HRIs
Iowa farmers interested in selling their products locally wanted more information about the institutional-type markets for these foods so they could determine how to work with these markets.</p
Rural regeneration through direct marketing of Audubon County meats
Audubon County Family Farms direct-marketed their farm products through the downtown farmers market in Des Moines. In addition to selling their products, the farmers encouraged dialogue with urban consumers through personal interaction and educational activities.</p