Reporting and dealing with missing quality of life data in RCTs : has the picture changed in the last decade?

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Latitude dependence of co-rotating shock acceleration

Energetic particle observations in the outer heliosphere (approx 12 A. U.) by the LECP instruments on the Voyager 1 and Voyager 2 spacecraft are discussed that show a definite latitude dependence of the number and intensity of particle enhancements produced by corotating interplanetary regions during an interval when no solar energetic particle events were observed. The particle enhancements are fewer in number and less intense at higher (approx 20 deg.) heliolatitudes. However, the similar spectral shapes of the accelerated particles at the two spacecraft indicate that the acceleration process is the same at the two latitudes, but less intense at the higher latitude

Neurotropic viruses and cerebral palsy: population based case-control study

Objective: To investigate the association between cerebral palsy and direct evidence for perinatal exposure to neurotropic viruses. Design: Population based case-control study. Setting: Adelaide Women's and Children's Hospital Research Laboratory. Participants and main outcome measures: Newborn screening cards of 443 white case patients with cerebral palsy and 883 white controls were tested for viral nucleic acids from enteroviruses and herpes viruses by using polymerase chain reaction. Herpes group A viruses included herpes simplex viruses 1 and 2 (HSV-1 and HSV-2), Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpes virus 8 (HHV-8), and herpes group B viruses included varicella zoster virus (VZV) and human herpes viruses 6 and 7 (HHV-6 and HHV-7). Results: The prevalence of viral nucleic acids in the control population was high: 39.8% of controls tested positive, and the prevalence was highest in preterm babies. The detection of herpes group B viral nucleic acids increased the risk of developing cerebral palsy (odds ratio 1.68, 95% confidence interval 1.09 to 2.59). Conclusions: Perinatal exposure to neurotropic viruses is associated with preterm delivery and cerebral palsy.Catherine S. Gibson, Alastair H. MacLennan, Paul N. Goldwater, Eric A. Haan, Kevin Priest and Gustaaf A. Dekker

Solar Energetic Particle Spectral Breaks

The five large solar particle events during October–November 2003 presented an opportunity to test shock acceleration models with in-situ observations. We use solar particle spectra of H to Fe ions, measured by instruments on ACE, SAMPEX, and GOES-11, to investigate the Q/M-dependence of spectral breaks in the 28 October 2003 event. We find that the break energies scale as (Q/M)^b with b ≈ 1.56 to 1.75, somewhat less than predicted. We also conclude that SEP spectra >100 MeV/nucleon are best fit by a double power-law shape. ©2005 American Institute of Physic

Ring-Pattern Dynamics in Smectic-C* and Smectic-C_A* Freely Suspended Liquid Crystal Films

Ring patterns of concentric 2pi-solitons in molecular orientation, form in freely suspended chiral smectic-C films in response to an in-plane rotating electric field. We present measurements of the zero-field relaxation of ring patterns and of the driven dynamics of ring formation under conditions of synchronous winding, and a simple model which enables their quantitative description in low polarization DOBAMBC. In smectic C_A* TFMHPOBC we observe an odd-even layer number effect, with odd number layer films exhibiting order of magnitude slower relaxation rates than even layer films. We show that this rate difference is due to much larger spontaneous polarization in odd number layer films.Comment: 4 RevTeX pgs, 4 eps figures, submitted to Phys. Rev. Let

Solar cycle variations of the energetic H/He intensity ratio at high heliolatitudes and in the ecliptic plane

International audienceWe study the variability of the heliospheric energetic proton-to-helium abundance ratios during different phases of the solar cycle. We use energetic particle, solar wind, and magnetic field data from the Ulysses, ACE and IMP-8 spacecraft to compare the H/He intensity ratio at high heliographic latitudes and in the ecliptic plane. During the first out-of-ecliptic excursion of Ulysses (1992?1996), the HI-SCALE instrument measured corotating energetic particle intensity enhancements characterized by low values ( 10) of the 0.5?1.0 MeV nucleon-1 H/He intensity ratio. During the second out-of-ecliptic excursion of Ulysses (1999?2002), the more frequent occurrence of solar energetic particle events resulted in almost continuously high ( 20) values of the H/He ratio, even at the highest heliolatitudes reached by Ulysses. Comparison with in-ecliptic measurements from an identical instrument on the ACE spacecraft showed similar H/He values at ACE and Ulysses, suggesting a remarkable uniformity of energetic particle intensities in the solar maximum heliosphere at high heliolatitudes and in the ecliptic plane. In-ecliptic observations of the H/He intensity ratio from the IMP-8 spacecraft show variations between solar maximum and solar minimum similar to those observed by Ulysses at high heliographic latitudes. We suggest that the variation of the H/He intensity ratio throughout the solar cycle is due to the different level of transient solar activity, as well as the different structure and duration that corotating solar wind structures have under solar maximum and solar minimum conditions. During solar minimum, the interactions between the two different types of solar wind streams (slow vs. fast) are strong and long-lasting, allowing for a continuous and efficient acceleration of interstellar pickup He +. During solar maximum, transient events of solar origin (characterized by high values of the H/He ratio) are able to globally fill the heliosphere. In addition, during solar maximum, the lack of strong recurrent high-speed solar wind streams, together with the dynamic character of the Sun, lead to weak and short-lived solar wind stream interactions. This results in a less efficient acceleration of pickup He +, and thus a higher value of the H/He intensity ratio

Modeling Life as Cognitive Info-Computation

This article presents a naturalist approach to cognition understood as a network of info-computational, autopoietic processes in living systems. It provides a conceptual framework for the unified view of cognition as evolved from the simplest to the most complex organisms, based on new empirical and theoretical results. It addresses three fundamental questions: what cognition is, how cognition works and what cognition does at different levels of complexity of living organisms. By explicating the info-computational character of cognition, its evolution, agent-dependency and generative mechanisms we can better understand its life-sustaining and life-propagating role. The info-computational approach contributes to rethinking cognition as a process of natural computation in living beings that can be applied for cognitive computation in artificial systems.Comment: Manuscript submitted to Computability in Europe CiE 201

Front propagation into unstable and metastable states in Smectic C* liquid crystals: linear and nonlinear marginal stability analysis

We discuss the front propagation in ferroelectric chiral smectics (SmC*) subjected to electric and magnetic fields applied parallel to smectic layers. The reversal of the electric field induces the motion of domain walls or fronts that propagate into either an unstable or a metastable state. In both regimes, the front velocity is calculated exactly. Depending on the field, the speed of a front propagating into the unstable state is given either by the so-called linear marginal stability velocity or by the nonlinear marginal stability expression. The cross-over between these two regimes can be tuned by a magnetic field. The influence of initial conditions on the velocity selection problem can also be studied in such experiments. SmC$^*$ therefore offers a unique opportunity to study different aspects of front propagation in an experimental system

Mesh inlay, mesh kit or native tissue repair for women having repeat anterior or posterior prolapse surgery: randomised controlled trial (PROSPECT)

Funding The project was funded by the National Institute for Health Research Health Technology Assessment Programme (Project Number 07/60/18). The Health Services Research Unit and the Health Economics Research Unit are funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorates. Acknowledgements The authors wish to thank the women who participated in the PROSPECT study. We also thank Margaret MacNeil for her secretarial support and data management; Dawn McRae and Lynda Constable for their trial management support; the programming team in CHaRT, led by Gladys McPherson; members of the Project Management Group for their ongoing advice and support of the study; and the staff at the recruitment sites who facilitated the recruitment, treatment and follow up of study participants.Peer reviewedPublisher PD