CP violation at LHCb and a novel measurement of hadronic charm inputs at BESIII

The angle γ of the Unitarity Triangle is measured by studying CP violation in B0 → DK∗(892)0 decays, where D denotes a superposition of the D0 and D0 mesons. The value γ = (49+22−19)◦ is determined, where the uncertainty combines the statistical and systematic sources. The measurement is made using a dataset with an integrated luminosity of 9fb-1, and is collected by the LHCb experiment in proton-proton collisions at centre-of-mass energies of 7, 8 and 13 TeV. The procedure examines CP violation across the kinematic phase space of the D to K0Sπ+π- and D to K0SK+K- decays. The angle γ is interpreted from the data using hadronic inputs describing the D decays. The values of these inputs are provided by the BESIII experiment using quantum-correlated DD meson pairs, rather than relying on those provided by an amplitude model. The second half of this thesis presents the determination of a hadronic charm parameter, specifically the strong-phase difference between D0 and D0 decays to the K-π+ final state, δKDπ. A dataset, which is collected by the BESIII experiment in e+e- collisions at centre-of-mass energies between 4.13 and 4.23 GeV, and has an integrated luminosity of 7.13fb-1, is used for the analysis. The parameter δKDπ is measured by exploiting interference in DD to K-π+ vs. X decays, where X is a CP eigenstate or K0Sπ+π-. It is determined to be δKDπ = (192.8+11.0+1.9-12.4-2.4)◦, where the first uncertainty is statistical and the second is systematic. The study presented is the first to observe and use the quantum correlations in DD pairs produced above the ψ(3770) resonance. At these higher energies, the DD pairs are produced in even and odd eigenstates of the charge-conjugation operator, C, compared to only the latter at ψ(3770). Simultaneously using the C-even and C-odd DD pairs allows access to novel experimental observables that significantly reduce systematic uncertainties

A Revised Historical Light Curve of Eta Carinae and the Timing of Close Periastron Encounters

The historical light curve of the 19th century "Great Eruption" of etaCar provides a striking record of violent instabilies encountered by the most massive stars. We report and analyze newly uncovered historical estimates of the visual brightness of etaCar during its eruption, and we correct some mistakes in the original record. The revised light curve looks substantially different from previous accounts: it shows two brief eruptions in 1838 and 1843 that resemble modern supernova impostors, while the final brightening in December 1844 marks the time when etaCar reached its peak brightness. We consider the timing of brightening events as they pertain to the putative binary system in etaCar: (1) The brief 1838 and 1843 events peaked within weeks of periastron if the pre-1845 orbital period is shorter than at present due to the mass loss of the eruption. Each event lasted only 100 days. (2) The main brightening at the end of 1844 has no conceivable association with periastron, beginning more than 1.5yr afterward. It lasted 10yr, with no obvious influence of periastron encounters during that time. (3) The 1890 eruption began to brighten at periastron, but took over 1yr to reach maximum and remained there for almost 10yr. A second periastron passage midway through the 1890 eruption had no effect. While evidence for a link between periastron encounters and the two brief precursor events is compelling, the differences between the three cases above make it difficult to explain all three phenomena with the same mechanism.Comment: 11 pages, 4 figures. submitted to MNRAS on october 12. updated reference

Evidence for the Rare Decay B -> K*ll and Measurement of the B -> Kll Branching Fraction

We present evidence for the flavor-changing neutral current decay $B\to K^*\ell^+\ell^-$ and a measurement of the branching fraction for the related process $B\to K\ell^+\ell^-$, where $\ell^+\ell^-$ is either an $e^+e^-$ or $\mu^+\mu^-$ pair. These decays are highly suppressed in the Standard Model, and they are sensitive to contributions from new particles in the intermediate state. The data sample comprises $123\times 10^6$ $\Upsilon(4S)\to B\bar{B}$ decays collected with the Babar detector at the PEP-II $e^+e^-$ storage ring. Averaging over $K^{(*)}$ isospin and lepton flavor, we obtain the branching fractions ${\mathcal B}(B\to K\ell^+\ell^-)=(0.65^{+0.14}_{-0.13}\pm 0.04)\times 10^{-6}$ and ${\mathcal B}(B\to K^*\ell^+\ell^-)=(0.88^{+0.33}_{-0.29}\pm 0.10)\times 10^{-6}$, where the uncertainties are statistical and systematic, respectively. The significance of the $B\to K\ell^+\ell^-$ signal is over $8\sigma$, while for $B\to K^*\ell^+\ell^-$ it is $3.3\sigma$.Comment: 7 pages, 2 postscript figues, submitted to Phys. Rev. Let

Measurement of the Branching Fraction for B- --> D0 K*-

We present a measurement of the branching fraction for the decay B- --> D0 K*- using a sample of approximately 86 million BBbar pairs collected by the BaBar detector from e+e- collisions near the Y(4S) resonance. The D0 is detected through its decays to K- pi+, K- pi+ pi0 and K- pi+ pi- pi+, and the K*- through its decay to K0S pi-. We measure the branching fraction to be B.F.(B- --> D0 K*-)= (6.3 +/- 0.7(stat.) +/- 0.5(syst.)) x 10^{-4}.Comment: 7 pages, 1 postscript figure, submitted to Phys. Rev. D (Rapid Communications

Molecular response to aromatase inhibitor treatment in primary breast cancer

BackgroundAromatase inhibitors such as anastrozole and letrozole are highly effective suppressants of estrogen synthesis in postmenopausal women and are the most effective endocrine treatments for hormone receptor positive breast cancer in such women. Little is known of the molecular effects of these agents on human breast carcinomas in vivo.MethodsWe randomly assigned primary estrogen receptor positive breast cancer patients to treatment with anastrozole or letrozole for 2 weeks before surgery. Expression profiling using cDNA arrays was conducted on pretreatment and post-treatment biopsies. Sample pairs from 34 patients provided sufficient RNA for analysis.ResultsProfound changes in gene expression were seen with both aromatase inhibitors, including many classical estrogen-dependent genes such as TFF1, CCND1, PDZK1 and AGR2, but also many other genes that are likely to represent secondary responses; decrease in the expression of proliferation-related genes were particularly prominent. Many upregulated genes are involved in extracellular matrix remodelling, including collagens and members of the small leucine-rich proteoglycan family (LUM, DCN, and ASPN). No significant differences were seen between letrozole and anastrozole in terms of molecular effects. The gene changes were integrated into a Global Index of Dependence on Estrogen (GIDE), which enumerates the genes changing by at least twofold with therapy. The GIDE varied markedly between tumours and related significantly to pretreatment levels of HER2 and changes in immunohistochemically detected Ki67.ConclusionOur findings identify the transcriptional signatures associated with aromatase inhibitor treatment of primary breast tumours. Larger datasets using this approach should enable identification of estrogen-dependent molecular changes, which are the determinants of benefit or resistance to endocrine therapy

Measurement of the branching fraction for B−→D0K∗−B^- \to D^0 K^{*-}

We present a measurement of the branching fraction for the decay B- --> D0 K*- using a sample of approximately 86 million BBbar pairs collected by the BaBar detector from e+e- collisions near the Y(4S) resonance. The D0 is detected through its decays to K- pi+, K- pi+ pi0 and K- pi+ pi- pi+, and the K*- through its decay to K0S pi-. We measure the branching fraction to be B.F.(B- --> D0 K*-)= (6.3 +/- 0.7(stat.) +/- 0.5(syst.)) x 10^{-4}