Quasi-two-body decays B→DK∗(892)→DKπB \to D K^*(892) \to D K \pi in the perturbative QCD approach

We study the quasi-two-body decays $B\to D K^*(892) \to D K\pi$ by employing the perturbative QCD approach. The two-meson distribution amplitudes \Phi_{K\pi}^{\text{P-wave}} are adopted to describe the final state interactions of the kaon-pion pair in the resonance region. The resonance line shape for the $P$-wave $K\pi$ component $K^*(892)$ in the time-like form factor $F_{K\pi}(s)$ is parameterized by the relativistic Breit-Wigner function. For most considered decay modes, the theoretical predictions for their branching ratios are consistent with currently available experimental measurements within errors. We also disscuss some ratios of the branching fractions of the concerned decay processes. More precise data from LHCb and Belle-II are expected to test our predictions.Comment: 10 pages, 3 figures and 2 tables.To be published in EPJ

Quasi-two-body decays B→ηc(1S,2S) [ρ(770),ρ(1450),ρ(1700)→] ππB \to \eta_c {(1S ,2S)}\;[\rho(770),\rho(1450),\rho(1700) \to ]\; \pi\pi in the perturbative QCD approach

In this paper, we calculated the branching ratios of the quasi-two-body decays $B \to \eta_c (1S ,2S)$ $[\rho(770), \rho(1450),\rho(1700)\to ] \pi\pi$ by employing the perturbative QCD (PQCD) approach. The contributions from the $P$-wave resonances $\rho(770)$, $\rho(1450)$ and $\rho(1700)$ were taken into account. The two-pion distribution amplitude $\Phi_{\pi\pi}^{\rm P}$ is parameterized by the vector current time-like form factor $F_{\pi}$ to study the considered decay modes. We found that (a) the PQCD predictions for the branching ratios of the considered quasi-two-body decays are in the order of $10^{-7} \sim 10^{-6}$, while the two-body decay rates ${\cal B}(B \to \eta_c{(1S,2S)} (\rho(1450),\rho(1700)))$ are extracted from those for the corresponding quasi-two-body decays; (b) the whole pattern of the pion form factor-squared $|F_\pi|^2$ measured by the BABAR Collaboration could be understood based on our theoretical results; (c) the general expectation based on the similarity between $B \to \eta_c \pi\pi$ and $B \to J/\psi \pi\pi$ decays are confirmed: $R_2(\eta_c)\approx 0.45$ is consistent with the measured $R_2(J/\psi)\approx 0.56\pm 0.09$ within errors; and (d) new ratios $R_3(\eta_c(1S))$ and $R_4(\eta_c(2S))$ among the branching ratios of the considered decay modes are defined and could be tested by future experiments.Comment: 10 pages, 3 figure

Fasciolopsis buski (Digenea: Fasciolidae) from China and India may represent distinct taxa based on mitochondrial and nuclear ribosomal DNA sequences

Sequences of primers used to amplify fragments of Fasciolopsis buski mitochondrial genome. (DOCX 17 kb

Problematika Penyelesaian Sengketa Kewenangan Lembaga Negara Oleh Mahkamah Konstitusi

According to Article 24C verse (1) of the 1945 Constitution, Constitutional court has an authority to examine the dispute among the state institution in which its authority is given by the constitution directly. But there is a certain problem in practice which is related to definition of “state institution” and “authorities are granted the Constitution” in the 1945 Constitution. This condition opens a debate the interpretation in executing the settlement on authority dispute among the institutions. In addition, should be considered the settlement of disputes the authority of institutions, whose authority derived from regulation other than the Constitution Menurut ketentuan Pasal 24C ayat (1) UUD NRI Tahun 1945, penyelesaian sengketa kewenangan lembaga negara yang kewenangannya diberikan oleh UUD merupakan kewenangan Mahkamah Konstitusi. Namun dalam praktiknya, proses penyelesaian sengketa kewenangan lembaga negara menghadapi problem tersendiri seiring tidak adanya batasan ruang lingkup dan definisi “lembaga negara” dan frasa “kewenangannya diberikan UUD” secara pasti dalam UUD NRI Tahun 1945. Situasi ini pada akhirnya menimbulkan multitafsir yang berpotensi mengakibatkan tidak efektifnya penyelesaian sengketa kewenangan lembaga negara di Indonesia. Selain itu, perlu dipikirkan mekanisme penyelesaian sengketa kewenangan lembaga yang kewenangannya bersumber dari peraturan selain UUD

Changes of monocyte human leukocyte antigen-DR expression as a reliable predictor of mortality in severe sepsis

INTRODUCTION: Many studies have shown that monocyte human leukocyte antigen-DR (mHLA-DR) expression may be a good predictor for mortality in severe septic patients. On the contrary, other studies found mHLA-DR was not a useful prognostic marker in severe sepsis. Few studies have taken changes of mHLA-DR during treatment into consideration. The objective of this study was to estimate the prognostic value of changes of mHLA-DR to predict mortality in severe sepsis. METHODS: In this prospective observational study, mHLA-DR was measured by flow cytometry in peripheral blood from 79 adult patients with severe sepsis. mHLA-DR levels were determined on day 0, 3, 7 after admission to the surgical intensive care unit (SICU) with a diagnosis of severe sepsis. ΔmHLA-DR(3 )and ΔmHLA-DR(7 )were defined as the changes in mHLA-DR value on day 3 and day 7 compared to that on day 0. Data were compared between 28-day survivors and non-survivors. Receiver operating characteristic (ROC) curves were plotted to measure the performance and discriminating threshold of ΔmHLA-DR(3), ΔmHLA-DR(7), ΔmHLA-DR(7-3), mHLA-DR(0), mHLA-DR(3 )and mHLA-DR(7 )in predicting mortality of severe sepsis. RESULTS: ROC curve analysis showed that ΔmHLA-DR(3 )and ΔmHLA-DR(7 )were reliable indicators of mortality in severe sepsis. A ΔmHLA-DR(3 )value of 4.8% allowed discrimination between survivors and non-survivors with a sensitivity of 89.0% and a specificity of 93.7%; similarly, ΔmHLA-DR(7 )value of 9% allowed discrimination between survivors and non-survivors with a sensitivity of 85.7% and a specificity of 90.0%. Patients with ΔmHLA-DR(3 )≤4.8% had higher mortality than those with ΔmHLA-DR(3 )> 4.8% (71.4% vs. 2.0%, OR 125.00, 95% CI 13.93 to 1121.67); patients with ΔmHLA-DR(7 )≤9% had higher mortality than those with ΔmHLA-DR(7 )> 9% (52.9% vs. 2.0%, OR 54.00, 95% CI 5.99 to 486.08). The mean change of mHLA-DR significantly increased in the survivor group with the passage of time; from day 0 to day 3 and day 7, changes were 6.45 and 16.90 (P < 0.05), respectively. CONCLUSIONS: The change of mHLA-DR over time may be a reliable predictor for mortality in patients with severe sepsis

C-F bond activation under transition-metal-free conditions

The unique properties of fluorine-containing organic compounds make fluorine substitution attractive for the development of pharmaceuticals and various specialty materials, which have inspired the evolution of diverse C-F bond activation techniques. Although many advances have been made in functionalizations of activated C-F bonds utilizing transition metal complexes, there are fewer approaches available for nonactivated C-F bonds due to the difficulty in oxidative addition of transition metals to the inert C-F bonds. In this regard, using Lewis acid to abstract the fluoride and light/radical initiator to generate the radical intermediate have emerged as powerful tools for activating those inert C-F bonds. Meanwhile, these transition-metal-free processes are greener, economical, and for the pharmaceutical industry, without heavy metal residues. This review provides an overview of recent C-F bond activations and functionalizations under transition-metal-free conditions. The key mechanisms involved are demonstrated and discussed in detail. Finally, a brief discussion on the existing limitations of this field and our perspective are presented