Gender bukan tabu: catatan perjalanan fasilitasi kelompok perempuan di Jambi

Cross-coupling of nitrogen with hydrocarbons under fragment coupling conditions stands to significantly impact chemical synthesis. Herein, we disclose a C­(sp³)–N fragment coupling reaction between terminal olefins and <i>N</i>-triflyl protected aliphatic and aromatic amines via Pd­(II)/SOX (sulfoxide-oxazoline) catalyzed intermolecular allylic C–H amination. A range of (56) allylic amines are furnished in good yields (avg. 75%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 <i>E</i>:<i>Z</i>). Mechanistic studies reveal that the SOX ligand framework is effective at promoting functionalization by supporting cationic π-allyl Pd

Molecular Complexity via C–H Activation: A Dehydrogenative Diels–Alder Reaction

Traditionally, C–H oxidation reactions install oxidized functionality onto a preformed molecular skeleton, resulting in a local molecular change. The use of C–H activation chemistry to construct complex molecular scaffolds is a new area with tremendous potential in synthesis. We report a Pd(II)/bis-sulfoxide-catalyzed dehydrogenative Diels–Alder reaction that converts simple terminal olefins into complex cycloadducts in a single operation

Molecular Complexity via C–H Activation: A Dehydrogenative Diels–Alder Reaction

Traditionally, C–H oxidation reactions install oxidized functionality onto a preformed molecular skeleton, resulting in a local molecular change. The use of C–H activation chemistry to construct complex molecular scaffolds is a new area with tremendous potential in synthesis. We report a Pd(II)/bis-sulfoxide-catalyzed dehydrogenative Diels–Alder reaction that converts simple terminal olefins into complex cycloadducts in a single operation

Molecular Complexity via C–H Activation: A Dehydrogenative Diels–Alder Reaction

Traditionally, C–H oxidation reactions install oxidized functionality onto a preformed molecular skeleton, resulting in a local molecular change. The use of C–H activation chemistry to construct complex molecular scaffolds is a new area with tremendous potential in synthesis. We report a Pd(II)/bis-sulfoxide-catalyzed dehydrogenative Diels–Alder reaction that converts simple terminal olefins into complex cycloadducts in a single operation

Catalytic Intermolecular Allylic CH Alkylation

Catalytic Intermolecular Allylic CH Alkylatio

Catalytic Intermolecular Allylic CH Alkylation

Catalytic Intermolecular Allylic CH Alkylatio

Molecular Complexity via C–H Activation: A Dehydrogenative Diels–Alder Reaction

Traditionally, C–H oxidation reactions install oxidized functionality onto a preformed molecular skeleton, resulting in a local molecular change. The use of C–H activation chemistry to construct complex molecular scaffolds is a new area with tremendous potential in synthesis. We report a Pd(II)/bis-sulfoxide-catalyzed dehydrogenative Diels–Alder reaction that converts simple terminal olefins into complex cycloadducts in a single operation

Catalyst-Controlled Aliphatic C–H Oxidations with a Predictive Model for Site-Selectivity

Selective aliphatic C-H bond oxidations may have a profound impact on synthesis because these bonds exist across all classes of organic molecules. Central to this goal are catalysts with broad substrate scope (small-molecule-like) that predictably enhance or overturn the substrate’s inherent reactivity preference for oxidation (enzyme-like). We report a simple small-molecule, non-heme iron catalyst that achieves predictable catalyst-controlled site-selectivity in preparative yields over a range of topologically diverse substrates. A catalyst reactivity model quantitatively correlates the innate physical properties of the substrate to the site-selectivities observed as a function of the catalyst

Catalytic Intermolecular Allylic CH Alkylation

Catalytic Intermolecular Allylic CH Alkylatio

Allylic C−H Amination for the Preparation of <i>syn</i>-1,3-Amino Alcohol Motifs

A highly selective and general Pd/sulfoxide-catalyzed allylic C−H amination reaction en route to syn-1,3-amino alcohol motifs is reported. Key to achieving this reactivity under mild conditions is the use of electron-deficient N-nosyl carbamate nucleophiles that are thought to promote functionalization by furnishing higher concentrations of anionic species in situ. The reaction is shown to be orthogonal to classical C−C bond-forming/-reduction sequences as well as nitrene-based C−H amination methods