THE ROLE OF THE FOREIGN CAPITAL IN THE INTEGRATION PROCESS OF REPUBLIC OF MACEDONIA

Foreign capital has significant role for every national economy, regardless of its level of development. For the developed countries it is necessary to support sustainable development. For the developing countries, it’s used to increase accumulation and rate of investments to create conditions for more intensive economic growth. For the transition countries, it’s useful to carry out the reforms and cross to open economy, to cross the past long term problems and to create conditions for stable and continuous growth of GDP, as well as integration in world economy. In accordance with low level of accumulation and rate of development, Macedonia as a transition country has a very big need for foreign capital. When we talk about the foreign capital and its need and significance for the Macedonian economy, on the first place we have in mind the foreign direct investments, that result by the great number of externalizes produced by FDI for the national economy. But, also credit and loan as traditional form of transfer of capital in international economic relations, it will be useful for the growth only if it is at the reasonable level (in regard of the national external debt) from one side, and if its use in the development of a certain economy is efficient, from other side.Development of the national economy; Foreign capital; Credits and loans; Foreign direct investments.

Regulation of vacuolar H+-ATPase activity by the Cdc42 effector Ste20 in Saccharomyces cerevisiae

In the budding yeast Saccharomyces cerevisiae, the Cdc42 effector Ste20 plays a crucial role in the regulation of filamentous growth, a response to nutrient limitation. Using the split-ubiquitin technique, we found that Ste20 forms a complex with Vma13, an important regulatory subunit of vacuolar H(+)-ATPase (V-ATPase). This protein-protein interaction was confirmed by a pulldown assay and coimmunoprecipitation. We also demonstrate that Ste20 associates with vacuolar membranes and that Ste20 stimulates V-ATPase activity in isolated vacuolar membranes. This activation requires Ste20 kinase activity and does not depend on increased assembly of the V1 and V0 sectors of the V-ATPase, which is a major regulatory mechanism. Furthermore, loss of V-ATPase activity leads to a strong increase in invasive growth, possibly because these cells fail to store and mobilize nutrients efficiently in the vacuole in the absence of the vacuolar proton gradient. In contrast to the wild type, which grows in rather small, isolated colonies on solid medium during filamentation, hyperinvasive vma mutants form much bigger aggregates in which a large number of cells are tightly clustered together. Genetic data suggest that Ste20 and the protein kinase A catalytic subunit Tpk2 are both activated in the vma13Δ strain. We propose that during filamentous growth, Ste20 stimulates V-ATPase activity. This would sustain nutrient mobilization from vacuolar stores, which is beneficial for filamentous growth.The project was supported by Deutsche Forschungsgemeinschaft grant HO 2098/3 to T.H. and NIH grant R01 GM50322 to P.M.K

Systems and certification issues for civil transport aircraft flow control systems

This article is placed here with permission from the Royal Aeronautical Society - Copyright @ 2009 Royal Aeronautical SocietyThe use of flow control (FC) technology on civil transport aircraft is seen as a potential means of providing a step change in aerodynamic performance in the 2020 time frame. There has been extensive research into the flow physics associated with FC. This paper focuses on developing an understanding of the costs and design drivers associated with the systems needed and certification. The research method adopted is based on three research strands: 1. Study of the historical development of other disruptive technologies for civil transport aircraft, 2. Analysis of the impact of legal and commercial requirements, and 3. Technological foresight based on technology trends for aircraft currently under development. Fly by wire and composite materials are identified as two historical examples of successful implementation of disruptive new technology. Both took decades to develop, and were initially developed for military markets. The most widely studied technology similar to FC is identified as laminar flow control. Despite more than six decades of research and arguably successful operational demonstration in the 1990s this has not been successfully transitioned to commercial products. Significant future challenges are identified in cost effective provision of the additional systems required for environmental protection and in service monitoring of FC systems particularly where multiple distributed actuators are envisaged. FC generated noise is also seen as a significant challenge. Additional complexity introduced by FC systems must also be balanced by the commercial imperative of dispatch reliability, which may impose more stringent constraints than legal (certification) requirements. It is proposed that a key driver for future successful application of FC is the likely availability of significant electrical power generation on 787 aircraft forwards. This increases the competitiveness of electrically driven FC systems compared with those using engine bleed air. At the current rate of progress it is unlikely FC will make a contribution to the next generation of single-aisle aircraft due to enter service in 2015. In the longer term, there needs to be significant movement across a broad range of systems technologies before the aerodynamic benefits of FC can be exploited.This work is supported by the EU FP6 AVERT (AerodynamicValidation of Emissions Reducing Technologies) project

Relacions sexuals i rendiment físic: aclarint el mite de l’efecte perjudicial de mantenir relacions sexuals coitals abans de participar en activitats físiques extenuants

La nostra revisió bibliogràfica pretén presentar l’evidència científica que contradiu el mite que mantenir relacions sexuals coitals abans de realitzar alguna activitat que requereix un rendiment físic màxim és perjudicial. Encara que, en l’actualitat, aquest mite es continua difonent en alguns ambients esportius, no existeixen estudis que indiquin que mantenir relacions sexuals coitals sigui perjudicial. Prenent com a base mesuraments de paràmetres fisiològics, metabòlics i psicològics, s’ha arribat a determinar que el coit no afecta negativament ni positivament el rendiment físic. L’escassa evidència científica fa que aquest tema prengui importància i se suggereix que es realitzin més investigacions per tal d’oferir consells i educació apropiada a les poblacions físicament actives de diverses edats, com és el cas dels esportistes

Symptomatic treatment of children with anti-NMDAR encephalitis.

Abstract AIM: We performed the first study on the perceived benefit and adverse effects of symptomatic management in children with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. METHOD: A retrospective chart review was undertaken at two tertiary paediatric hospitals in Australia and New Zealand. We included 27 children (12 males, 15 females; mean age at admission 7y 1mo) with anti-NMDAR antibodies in serum or cerebrospinal fluid with a typical clinical syndrome. RESULTS: Only two out of 27 patients were white, whereas 16 out of 27 patients were from the Pacific Islands/New Zealand Maori. The mean duration of admission was 69 days (10-224d) and 48% of patients (13/27) needed treatment in an intensive care setting. A mean of eight medications per patient was used for symptomatic management. Symptoms treated were agitation (n=25), seizures (n=24), movement disorders (n=23), sleep disruption (n=17), psychiatric symptoms (n=10), and dysautonomia (n=four). The medications used included five different benzodiazepines (n=25), seven anticonvulsants (n=25), eight sedatives and sleep medications (n=23), five antipsychotics (n=12), and five medications for movement disorders (n=10). Sedative and sleep medications other than benzodiazepines were the most effective, with a mean benefit of 67.4% per medication and a mean adverse effect-benefit ratio of 0.04 per medication. Antipsychotic drugs were used for a short duration (median 9d), and had the poorest mean benefit per medication of 35.4% and an adverse effect-benefit ratio of 2.0 per medication. INTERPRETATION: Long-acting benzodiazepines, anticonvulsants, and clonidine can treat multiple symptoms. Patients with anti-NMDAR encephalitis appear vulnerable to antipsychotic-related adverse effects. Pacific Islanders appear to have a vulnerability to anti-NMDAR encephalitis in our region

Transgenic Overexpression of LARGE Induces alpha-Dystroglycan Hyperglycosylation in Skeletal and Cardiac Muscle

Background: LARGE is one of seven putative or demonstrated glycosyltransferase enzymes defective in a common group of muscular dystrophies with reduced glycosylation of alpha-dystroglycan. Overexpression of LARGE induces hyperglycosylation of alpha-dystroglycan in both wild type and in cells from dystroglycanopathy patients, irrespective of their primary gene defect, restoring functional glycosylation. Viral delivery of LARGE to skeletal muscle in animal models of dystroglycanopathy has identical effects in vivo, suggesting that the restoration of functional glycosylation could have therapeutic applications in these disorders. Pharmacological strategies to upregulate Large expression are also being explored.Methodology/Principal Findings: In order to asses the safety and efficacy of long term LARGE over-expression in vivo, we have generated four mouse lines expressing a human LARGE transgene. On observation, LARGE transgenic mice were indistinguishable from the wild type littermates. Tissue analysis from young mice of all four lines showed a variable pattern of transgene expression: highest in skeletal and cardiac muscles, and lower in brain, kidney and liver. Transgene expression in striated muscles correlated with alpha-dystroglycan hyperglycosylation, as determined by immunoreactivity to antibody IIH6 and increased laminin binding on an overlay assay. Other components of the dystroglycan complex and extracellular matrix ligands were normally expressed, and general muscle histology was indistinguishable from wild type controls. Further detailed muscle physiological analysis demonstrated a loss of force in response to eccentric exercise in the older, but not in the younger mice, suggesting this deficit developed over time. However this remained a subclinical feature as no pathology was observed in older mice in any muscles including the diaphragm, which is sensitive to mechanical load-induced damage.Conclusions/Significance: This work shows that potential therapies in the dystroglycanopathies based on LARGE upregulation and alpha-dystroglycan hyperglycosylation in muscle should be safe

Multispace and Multilevel BDDC

BDDC method is the most advanced method from the Balancing family of iterative substructuring methods for the solution of large systems of linear algebraic equations arising from discretization of elliptic boundary value problems. In the case of many substructures, solving the coarse problem exactly becomes a bottleneck. Since the coarse problem in BDDC has the same structure as the original problem, it is straightforward to apply the BDDC method recursively to solve the coarse problem only approximately. In this paper, we formulate a new family of abstract Multispace BDDC methods and give condition number bounds from the abstract additive Schwarz preconditioning theory. The Multilevel BDDC is then treated as a special case of the Multispace BDDC and abstract multilevel condition number bounds are given. The abstract bounds yield polylogarithmic condition number bounds for an arbitrary fixed number of levels and scalar elliptic problems discretized by finite elements in two and three spatial dimensions. Numerical experiments confirm the theory.Comment: 26 pages, 3 figures, 2 tables, 20 references. Formal changes onl

Better Performance through Enterprise Governance and Management Process Innovation

All the changes we are facing today take place within the global economic environment. These changes are caused by increasingly important inventions, suggestions, potential innovations, and innovations (and their diffusion to many users) resulting from crucially needed creativeness and innovativeness, new ideas, and constructive thinking; we are living in the era of different viewpoints and each of them originate from different knowledge, values, and experiences. This is why also the enterprise’s performance, and the ways of its achievement are continuously changing. One way of reaching enterprise competitiveness is provided by enterprise governance’s and management’s process innovation (GMPI) whose importance we will try to introduce here. We will discuss about enterprise policy, strategic management, innovativeness, competitiveness, and better performance of enterprises on the basis of GMPI.

Thin electron-scale layers at the magnetopause

We use data from the four Cluster satellites to examine the microphysics of a thin electron-scale layer discovered on the magnetospheric side of the magnetopause. Here the ion and electron motions are decoupled in a layer about 20 km (a few electron scales) wide, including currents and strong electric fields. In this layer the electrons are E x B drifting with the ions as a background, and the region can be described by Hall MHD physics. A unique identification of the source of the thin layer is not possible, but our observations are consistent with recent simulations showing thin layers associated with the separatrix extending far away from a reconnection diffusion region