Second Chances for Paisley Shawls

Historic collections include garments recycled from old paisley shawls. Shawls enjoyed popularity in the nineteenth century, reaching their peak in the 1850s and 1860s. When the crinoline changed to the bustle circa 1870, paisley shawls faded from fashion. This project asked the question: what happened to paisley shawls after they went out of style? Using a material culture model, the study examined six paisley garments in a university collection as examples of recycling and reuse. Remodeling efforts dated from 1870s to 1940s. Reasons for remodeling paisley shawls into garments over this long stretch of time are varied. First is the practical reason of revamping a luxury textile no longer in fashion. Second, the large shawls provided fabric that could be repurposed during wartime when Americans experienced shortages. Third, the paisley motif, with its exotic origins in India, tapped into the Orientalism that permeated the early years of the twentieth century

Serum Amyloid A Facilitates Early Lesion Development in \u3cem\u3eLdlr\u3csup\u3e-/-\u3c/sup\u3e\u3c/em\u3e Mice

BACKGROUND: Atherosclerosis is a chronic inflammatory disorder, and several studies have demonstrated a positive association between plasma serum amyloid A (SAA) levels and cardiovascular disease risk. The aim of the study was to examine whether SAA has a role in atherogenesis, the underlying basis of most cardiovascular disease. METHODS AND RESULTS: Mice globally deficient in acute-phase isoforms Saa1 and Saa2 (Saa-/-) were crossed to Ldlr-/- mice (Saa-/-Ldlr-/-). Saa-/-Ldlr-/- mice demonstrated a 31% reduction in lesional area in the ascending aorta but not in the aortic root or innominate artery after consuming a high-fat, high-cholesterol Western-type diet for 6 weeks. The lesions were predominantly macrophage foam cells. The phenotype was lost in more mature lesions in mice fed a Western-type diet for 12 weeks, suggesting that SAA is involved in early lesion development. The decreased atherosclerosis in the Saa-/-Ldlr-/- mice occurred despite increased levels of blood monocytes and was independent of plasma lipid levels. SAA is produced predominantly by hepatocytes and macrophages. To determine which source of SAA may have a dominant role in lesion development, bone marrow transplantation was performed. Ldlr-/- mice that received bone marrow from Saa-/-Ldlr-/- mice had slightly reduced ascending aorta atherosclerosis compared with Saa-/-Ldlr-/- mice receiving bone marrow from Ldlr-/- mice, indicating that the expression of SAA by macrophages may have an important influence on atherogenesis. CONCLUSIONS: The results indicate that SAA produced by macrophages promotes early lesion formation in the ascending aorta

Propuesta internacional para la creación de una asignatura obligatoria de mediación y resolución colaborativa de conflictos para el grado de Trabajo Social y otros grados afines

El presente proyecto tiene como principal objetivo la elaboración una propuesta para la creación de una asignatura de mediación y resolución colaborativa de conflictos que pueda ser aplicada en diversos países, áreas de conocimiento y titulaciones, pero de forma específica en el grado en Trabajo Social de la UCM

Second Chances for Paisley Shawls

Historic collections include garments recycled from old paisley shawls. Shawls enjoyed popularity in the nineteenth century, reaching their peak in the 1850s and 1860s. When the crinoline changed to the bustle circa 1870, paisley shawls faded from fashion. This project asked the question: what happened to paisley shawls after they went out of style? Using a material culture model, the study examined six paisley garments in a university collection as examples of recycling and reuse. Remodeling efforts dated from 1870s to 1940s. Reasons for remodeling paisley shawls into garments over this long stretch of time are varied. First is the practical reason of revamping a luxury textile no longer in fashion. Second, the large shawls provided fabric that could be repurposed during wartime when Americans experienced shortages. Third, the paisley motif, with its exotic origins in India, tapped into the Orientalism that permeated the early years of the twentieth century.</p

4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apolipoprotein E-null mice

Our objective was to contrast the effect of apolipoprotein (apo) A-I mimetic peptides, such as 4F and 4F-Pro-4F (Pro), on nascent and mature atherosclerotic lesions and on levels of antibodies against oxidation-specific epitopes. Chow-fed apoE−/− mice were injected intraperitoneally with either the 4F peptide or a tandem helix apoA-I mimetic peptide (Pro) every other day. Mice treated with 4F, but not Pro, for 4 wk starting at 10 wk of age showed a dramatic decrease in atherosclerosis at 2 arterial sites. However, neither peptide was effective in mice treated for 8 wk starting at 20 wk of age; lesions were larger and more mature at this time point. Peptide treatment caused increased production of antibodies against oxidation-specific epitopes, including a disproportionate induction of the IgM natural antibody (NAb) E06/T15 to oxidized phospholipids. In summary, 4F, but not the tandem peptide Pro, effectively inhibited early atherogenesis but was ineffective against more mature lesions. Two different apoA-I mimetic peptides increased titers of natural antibodies against oxidation-specific epitopes.—Wool, G. D., Cabana, V. G., Lukens, J., Shaw, P. X., Binder, C. J., Witztum, J. L., Reardon, C. A., Getz, G. S. 4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apolipoprotein E-null mice

Citrullination of proteins: A common post-translational modification pathway induced by different nanoparticles in vitro and in vivo

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