Contributions to the Quaternary Geology of Northern Maine and Adjacent Canada

Contributions to the Quaternary Geology of Northern Maine and Adjacent Canada Bulletin 37 - Maine Geological Survey, Department of Conservation, Augusta, Maine 04333 (1988). Contents: Introduction / A GEOMORPHIC METHOD FOR RECONSTRUCTING PALEO ICE SHEETS, Part I: GLACIAL GEOLOGY. - T. Hughes and J. Fastook / A GEOMORPHIC METHOD FOR RECONSTRUCTING PALEO ICE SHEETS, Part II: GLACIOLOGY. - J. Fastook and T. Hughes / TILL STRATIGRAPHY AT THE BALD MOUNTAIN MINE SITE, NORTHERN MAINE - W. R. Holland and F. F. Bragdon / GLACIAL DISPERSAL FROM THE PRIESTLY LAKE AND DEBOULLIE PLUTONS, NORTHERN MAINE - E. F. Halter / GLACIATION OF NORTHWESTERN MAINE - T. V. Lowell and J. S. Kite / AN UNUSUAL GLACIAL STRATIGRAPHY EXPOSED IN THE AROOSTOOK RIVER VALLEY, NORTHERN MAINE - H. W. Borns, Jr. and M. P. Borns / DEGLACIATION OF NORTHWESTERN MAINE - T. V. Lowell and J. S. Kite / DEGLACIATION AND STRATIGRAPHY OF THE LOWER ST. LAWRENCE VALLEY AND APPALACHIAN MOUNTAINS OF SOUTHEASTERN QUEBEC - P. LaSalle / QUATERNARY GEOLOGY OF MADAWASKA COUNTY, WESTERN NEW BRUNSWICK: A BRIEF OVERVIEW - V. N. Rampton / ICE MOVEMENTS IN MADAWASKA AND VICTORIA COUNTIES, NORTHWESTERN NEW BRUNSWICK - M. Rappol / POSTGLACIAL HISTORY OF THE UPPER ST. JOHN DRAINAGE BASIN - J. S. Kite and R. Stuckenrath / THE ARCHAEOLOGY OF THE UPPER ST. JOHN RIVER: OVERVIEW AND INTERPRETATION - G. P. Nicholashttps://digitalcommons.usm.maine.edu/me_collection/1188/thumbnail.jp

Macrophage biology in development, homeostasis and disease

Macrophages the most plastic cells of the hematopoietic system are found in all tissues and exhibit great functional diversity. They have roles in development, homeostasis, tissue repair, and immunity. While anatomically distinct, resident tissue macrophages exhibit different transcriptional profiles, and functional capabilities, they are all required for the maintenance of homeostasis. However, these reparative and homeostatic functions can be subverted by chronic insults, resulting in a causal association of macrophages with disease states. In this review, we discuss how macrophages regulate normal physiology and development and provide several examples of their pathophysiologic roles in disease. We define the “hallmarks” of macrophages performing particular functions, taking into account novel insights into the diversity of their lineages, identity, and regulation. This diversity is essential to understand because macrophages have emerged as important therapeutic targets in many important human diseases