The LSND and MiniBooNE Oscillation Searches at High Δm2\Delta m^2

This paper reviews the results of the LSND and MiniBooNE experiments. The primary goal of each experiment was to effect sensitive searches for neutrino oscillations in the mass region with $\Delta m^2 \sim 1$ eV$^2$. The two experiments are complementary, and so the comparison of results can bring additional information with respect to models with sterile neutrinos. Both experiments obtained evidence for $\bar \nu_\mu \rightarrow \bar \nu_e$ oscillations, and MiniBooNE also observed a $\nu_\mu \rightarrow \nu_e$ excess. In this paper, we review the design, analysis, and results from these experiments. We then consider the results within the global context of sterile neutrino oscillation models. The final data sets require a more extended model than the simple single sterile neutrino model imagined at the time that LSND drew to a close and MiniBooNE began. We show that there are apparent incompatibilities between data sets in models with two sterile neutrinos. However, these incompatibilities may be explained with variations within the systematic error. Overall, models with two (or three) sterile neutrinos seem to succeed in fitting the global data, and they make interesting predictions for future experiments.Comment: Posted with permission from the Annual Review of Nuclear and Particle Science, Volume 63. \c{opyright} 2013 by Annual Reviews, http://www.annualreviews.or

Solving the mystery of human sleep schedules one mutation at a time.

Sleep behavior remains one of the most enigmatic areas of life. The unanswered questions range from "why do we sleep?" to "how we can improve sleep in today's society?" Identification of mutations responsible for altered circadian regulation of human sleep lead to unique opportunities for probing these territories. In this review, we summarize causative circadian mutations found from familial genetic studies to date. We also describe how these mutations mechanistically affect circadian function and lead to altered sleep behaviors, including shifted or shortening of sleep patterns. In addition, we discuss how the investigation of mutations can not only expand our understanding of the molecular mechanisms regulating the circadian clock and sleep duration, but also bridge the pathways between clock/sleep and other human physiological conditions and ailments such as metabolic regulation and migraine headaches

Effects of Alternative Cropping Patterns and Management Decisions on Soil Erosion and Revenue, Region VII, North Dakota

This report focuses on the economic impact of selected agricultural management policies and the corresponding effect upon soil erosion.Farm Management, Land Economics/Use,

Parity Reversing Involutions on Plane Trees and 2-Motzkin Paths

The problem of counting plane trees with $n$ edges and an even or an odd number of leaves was studied by Eu, Liu and Yeh, in connection with an identity on coloring nets due to Stanley. This identity was also obtained by Bonin, Shapiro and Simion in their study of Schr\"oder paths, and it was recently derived by Coker using the Lagrange inversion formula. An equivalent problem for partitions was independently studied by Klazar. We present three parity reversing involutions, one for unlabelled plane trees, the other for labelled plane trees and one for 2-Motzkin paths which are in one-to-one correspondence with Dyck paths.Comment: 8 pages, 4 figure

Casein kinase iδ mutations in familial migraine and advanced sleep phase.

Migraine is a common disabling disorder with a significant genetic component, characterized by severe headache and often accompanied by nausea, vomiting, and light sensitivity. We identified two families, each with a distinct missense mutation in the gene encoding casein kinase Iδ (CKIδ), in which the mutation cosegregated with both the presence of migraine and advanced sleep phase. The resulting alterations (T44A and H46R) occurred in the conserved catalytic domain of CKIδ, where they caused reduced enzyme activity. Mice engineered to carry the CKIδ-T44A allele were more sensitive to pain after treatment with the migraine trigger nitroglycerin. CKIδ-T44A mice also exhibited a reduced threshold for cortical spreading depression (believed to be the physiological analog of migraine aura) and greater arterial dilation during cortical spreading depression. Astrocytes from CKIδ-T44A mice showed increased spontaneous and evoked calcium signaling. These genetic, cellular, physiological, and behavioral analyses suggest that decreases in CKIδ activity can contribute to the pathogenesis of migraine

Retrieved Products from Simulated Hyperspectral Observations of a Hurricane

This research uses GCM derived products, with 1 km spatial resolution and sampled every 10 minutes, over a moving area following the track of a simulated severe Atlantic storm. Model products were aggregated over sounder footprints corresponding to 13 km in LEO, 2 km in LEO, and 5 km in GEO sampled every 72 minutes. We simulated radiances for instruments with AIRS-like spectral coverage, spectral resolution, and channel noise, using these aggregated products as the truth, and analyzed them using a slightly modified version of the operational AIRS Version-6 retrieval algorithm. Accuracy of retrievals obtained using simulated AIRS radiances with a 13 km footprint was similar to that obtained using real AIRS data. Spatial coverage and accuracy of retrievals are shown for all three sounding scenarios. The research demonstrates the potential significance of flying Advanced AIRS-like instruments on future LEO and GEO missions