The Influence of Hydrogen Bonds on the Roaming Reaction

Roaming bypasses the conventional transition state and is a significant reaction pathway due to the unusual energy distributions of its products; however, its reaction pathway under external environmental interactions remains unclear. Herein, we report for the first time the roaming process of nitrobenzene, which is influenced by the hydrogen bonds (H-bonds) between nitro- and phenyl radicals and water molecules in the gas phase. Notably, despite the fact that the single water structure produces a higher but narrower barrier, whereas the double water structure leads to a lower but wider barrier, the roaming reaction still occurs. The underlying mechanism responsible for these influences of H-bonds is ascribed to the dramatically changed polarization and correlation interactions between the roaming radicals. The reaction rates and thermal perturbation probabilities are also remarkably influenced due to the presence of the H-bonds, by approximately 2 orders of magnitude. It is anticipated that this work will encourage the promising feasibility of introducing environmental molecules to modulate the roaming reaction

Additional file 1 of Efficacy and safety of mesenchymal stem cell therapy in liver cirrhosis: a systematic review and meta-analysis

Additional file 1. Figure S1: Forest plot of secondary indicators: (A): ALT levels (B): AST levels. (C): TBIL levels. (D): INR levels. Figure S2: Time subgroup of ALT levels. Figure S3: Time subgroup of AST levels. Figure S4: Time subgroup of TBIL levels