14 research outputs found

    Organization and management of clusters in Russia in the context of import substitution

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    The article covers the trends of the agribusiness development in Russia. It is shown that it is desirable to develop organizational-economic forms of entrepreneurship based on the cluster approach in the modern realities. The most famous agribusiness clusters in the world are explored. Regions of Russia that have achieved the most significant results in agribusiness clustering are mentioned. It is found that the establishment of agribusiness in Russia is defined by the political decision of regional authorities rather than based on research and development. An algorithm for establishing the agribusiness cluster is proposed, which includes four stages: methodological, analytical, organizational-economic and control. The key areas of state support for the development of agribusiness clusters in Russia are defined.peer-reviewe

    ΠœΠΎΡ€Ρ„ΠΎΡ„Π΅Π½ΠΎΡ‚ΠΈΠΏΠΈΡ‡Π΅ΡΠΊΠΈΠΉ ΠΏΡ€Π΅Π΄ΠΈΠΊΡ‚ΠΎΡ€ развития Π²ΠΈΡΡ†Π΅Ρ€Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ оТирСния Ρƒ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΡˆΠΈΠ·ΠΎΡ„Ρ€Π΅Π½ΠΈΠ΅ΠΉ, ΠΏΠΎΠ»ΡƒΡ‡Π°ΡŽΡ‰ΠΈΡ… Π°Π½Ρ‚ΠΈΠΏΡΠΈΡ…ΠΎΡ‚ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ Ρ‚Π΅Ρ€Π°ΠΏΠΈΡŽ

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    Objective: revealing the role of morphophenotypic indices in the development of visceral obesity in patients with schizophrenia receiving quetiapine and risperidone therapy.Materials and methods. 56 indoor patients with schizophrenia who received quetiapine (n = 23) or risperidone (n = 33) at medium doses were examined. Included persons were from 18 to 65 years old with at least a 1 year history of disease, the condition of which met the criteria of schizophrenia according to ICD-10. The Basis map of sociodemographic and clinical-dynamic signs for patients with schizophrenia was filled in, PANSS in the adapted Russian version – SCI-PANSS, noninvasive bioimpedancemetry, measurement of growth, transversethoracic, biacromial and bicrystal diameter, with calculation of body mass indexes, Tanner and Rees – Eysenk and definition of integral morphophenotypic indicators were carried out. Statistical processing was performed using Student’s t-test with a preliminary estimate of Pearson’s Ο‡2 normal distribution, the Mann – Whitney U test to compare independent samples, the Spearman correlation analysis, the two-sided Fisher test.Results. There were no significant differences in both subgroups in terms of bioimpedancemetry. The correlation between the level of visceral fat and the Rees – Eysenk index in patients receiving risperidone was a moderate inverse: the greater the value of the Rees – Eysenk index, the lower the level of visceral fat (r = –0.73381, t = –4.70833, p = 0.00015). The correlation between the Tanner index and the level of visceral fat in the quetiapine subgroup was strong: the larger the Tanner index, the higher the visceral fat level (r = 0.7763, t = 4.08481, p = 0.00181); in the risperidone subgroup, there was an average direct correlation (r = 0.48133, t = 2.39356, p = 0.02716).Conclusion. The magnitude of the Rees – Eysenk index of schizophrenic patients can be considered among other factors in the management of risperidone in individuals with asthenic physique. The determination of the Tanner index at the beginning of treatment can play the role of a prognostic factor in the development of visceral obesity in patients with schizophrenia in the planned use as a basic therapy for quetiapine.ЦСль – выявлСниС Ρ€ΠΎΠ»ΠΈ морфофСнотипичСских ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ Π² Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠΈ Π²ΠΈΡΡ†Π΅Ρ€Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ оТирСния Ρƒ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΡˆΠΈΠ·ΠΎΡ„Ρ€Π΅Π½ΠΈΠ΅ΠΉ, ΠΏΠΎΠ»ΡƒΡ‡Π°ΡŽΡ‰ΠΈΡ… Ρ‚Π΅Ρ€Π°ΠΏΠΈΡŽ ΠΊΠ²Π΅Ρ‚ΠΈΠ°ΠΏΠΈΠ½ΠΎΠΌ ΠΈ риспСридоном.ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. ΠžΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ‹ 56 стационарных ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с ΡˆΠΈΠ·ΠΎΡ„Ρ€Π΅Π½ΠΈΠ΅ΠΉ, ΠΏΡ€ΠΈΠ½ΠΈΠΌΠ°Π²ΡˆΠΈΡ… ΠΊΠ²Π΅Ρ‚ΠΈΠ°ΠΏΠΈΠ½ (n = 23) ΠΈΠ»ΠΈ риспСридон (n = 33) Π² срСдних Π΄ΠΎΠ·Π°Ρ…. Π’ΠΊΠ»ΡŽΡ‡Π°Π»ΠΈΡΡŒ Π»ΠΈΡ†Π° 18–65 Π»Π΅Ρ‚ с Π΄Π°Π²Π½ΠΎΡΡ‚ΡŒΡŽ ΠΊΠ°Ρ‚Π°ΠΌΠ½Π΅Π·Π° заболСвания Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ 1 Π³ΠΎΠ΄Π°, состояниС ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… соотвСтствовало критСриям ΡˆΠΈΠ·ΠΎΡ„Ρ€Π΅Π½ΠΈΠΈ ΠΏΠΎ ΠœΠšΠ‘-10. ΠŸΡ€ΠΈΠΌΠ΅Π½ΡΠ»ΠΈΡΡŒ Базисная ΠΊΠ°Ρ€Ρ‚Π° социо-дСмографичСских ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-динамичСских ΠΏΡ€ΠΈΠ·Π½Π°ΠΊΠΎΠ² для Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΡˆΠΈΠ·ΠΎΡ„Ρ€Π΅Π½ΠΈΠ΅ΠΉ, PANSS Π² Π°Π΄Π°ΠΏΡ‚ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠΉ русской вСрсии – SCI-PANSS. ΠŸΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈΡΡŒ нСинвазивная биоимпСдансомСтрия, ΠΈΠ·ΠΌΠ΅Ρ€Π΅Π½ΠΈΠ΅ роста, ΠΏΠΎΠΏΠ΅Ρ€Π΅Ρ‡Π½ΠΎ-Π³Ρ€ΡƒΠ΄Π½ΠΎΠ³ΠΎ, Π±ΠΈΠ°ΠΊΡ€ΠΎΠΌΠΈΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΈ Π±ΠΈΠΊΡ€ΠΈΡΡ‚Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ Π΄ΠΈΠ°ΠΌΠ΅Ρ‚Ρ€Π°, вычислСниС индСксов массы Ρ‚Π΅Π»Π°, Tanner ΠΈ Rees – Eysenk ΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»ΡΠ»ΠΈΡΡŒ ΠΈΠ½Ρ‚Π΅Π³Ρ€Π°Π»ΡŒΠ½Ρ‹Π΅ морфофСнотипичСскиС ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ. Π‘Ρ‚Π°Ρ‚ΠΈΡΡ‚ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ ΠΎΠ±Ρ€Π°Π±ΠΎΡ‚ΠΊΡƒ ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ с использованиСм t-критСрия Π‘Ρ‚ΡŒΡŽΠ΄Π΅Π½Ρ‚Π° с ΠΏΡ€Π΅Π΄Π²Π°Ρ€ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ ΠΎΡ†Π΅Π½ΠΊΠΎΠΉ Π½ΠΎΡ€ΠΌΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ распрСдСлСния, Ο‡2 ΠŸΠΈΡ€ΡΠΎΠ½Π°, U-критСрия Манна – Π£ΠΈΡ‚Π½ΠΈ для сравнСния нСзависимых Π²Ρ‹Π±ΠΎΡ€ΠΎΠΊ, коррСляционного Π°Π½Π°Π»ΠΈΠ·Π° Π‘ΠΏΠΈΡ€ΠΌΠ΅Π½Π° (r), двустороннСго критСрия Π€ΠΈΡˆΠ΅Ρ€Π°.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. НС выявлСно достовСрных Ρ€Π°Π·Π»ΠΈΡ‡ΠΈΠΉ Π² ΠΎΠ±Π΅ΠΈΡ… ΠΏΠΎΠ΄Π³Ρ€ΡƒΠΏΠΏΠ°Ρ… ΠΏΠΎ показатСлям биоимпСдансомСтрии. ΠšΠΎΡ€Ρ€Π΅Π»ΡΡ†ΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρƒ ΡƒΡ€ΠΎΠ²Π½Π΅ΠΌ Π²ΠΈΡΡ†Π΅Ρ€Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΆΠΈΡ€Π° ΠΈ индСксом Rees –Eysenk Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ², ΠΏΠΎΠ»ΡƒΡ‡Π°Π²ΡˆΠΈΡ… риспСридон, Π±Ρ‹Π»Π° ΡƒΠΌΠ΅Ρ€Π΅Π½Π½ΠΎΠΉ ΠΎΠ±Ρ€Π°Ρ‚Π½ΠΎΠΉ: Ρ‡Π΅ΠΌ большС Π²Π΅Π»ΠΈΡ‡ΠΈΠ½Π° индСкса Rees – Eysenk, Ρ‚Π΅ΠΌ Π½ΠΈΠΆΠ΅ ΡƒΡ€ΠΎΠ²Π΅Π½ΡŒ Π²ΠΈΡΡ†Π΅Ρ€Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΆΠΈΡ€Π° (r = –0,73381; t = –4,70833; p = 0,00015). ΠšΠΎΡ€Ρ€Π΅Π»ΡΡ†ΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρƒ Π²Π΅Π»ΠΈΡ‡ΠΈΠ½ΠΎΠΉ индСкса Tanner ΠΈ ΡƒΡ€ΠΎΠ²Π½Π΅ΠΌ Π²ΠΈΡΡ†Π΅Ρ€Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΆΠΈΡ€Π° Π² Π³Ρ€ΡƒΠΏΠΏΠ΅ ΠΊΠ²Π΅Ρ‚ΠΈΠ°ΠΏΠΈΠ½Π° Π±Ρ‹Π»Π° сильной прямой: Ρ‡Π΅ΠΌ большС индСкс Tanner, Ρ‚Π΅ΠΌ Π²Ρ‹ΡˆΠ΅ ΡƒΡ€ΠΎΠ²Π΅Π½ΡŒ Π²ΠΈΡΡ†Π΅Ρ€Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΆΠΈΡ€Π° (r = 0,77633; t = 4,08481; p = 0,00181); Π² Π³Ρ€ΡƒΠΏΠΏΠ΅ риспСридона наблюдалась срСдняя прямая коррСляция (r = 0,48133; t = 2,39356; p = 0,02716).Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. Π’Π΅Π»ΠΈΡ‡ΠΈΠ½Π° индСкса Rees – Eysenk Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΡˆΠΈΠ·ΠΎΡ„Ρ€Π΅Π½ΠΈΠ΅ΠΉ ΠΌΠΎΠΆΠ΅Ρ‚ Ρ€Π°ΡΡΠΌΠ°Ρ‚Ρ€ΠΈΠ²Π°Ρ‚ΡŒΡΡ срСди Π΄Ρ€ΡƒΠ³ΠΈΡ… Ρ„Π°ΠΊΡ‚ΠΎΡ€ΠΎΠ² ΠΏΡ€ΠΈ Ρ€Π΅ΡˆΠ΅Π½ΠΈΠΈ примСнСния риспСридона Ρƒ Π»ΠΈΡ† с астСничСским тСлослоТСниСм. ΠžΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ индСкса Tanner Π² Π½Π°Ρ‡Π°Π»Π΅ лСчСния ΠΌΠΎΠΆΠ΅Ρ‚ ΠΈΠ³Ρ€Π°Ρ‚ΡŒ Ρ€ΠΎΠ»ΡŒ прогностичСского Ρ„Π°ΠΊΡ‚ΠΎΡ€Π° развития Π²ΠΈΡΡ†Π΅Ρ€Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ оТирСния Ρƒ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΡˆΠΈΠ·ΠΎΡ„Ρ€Π΅Π½ΠΈΠ΅ΠΉ ΠΏΡ€ΠΈ ΠΏΠ»Π°Π½ΠΈΡ€ΡƒΠ΅ΠΌΠΎΠΌ использовании Π² качСствС базисной Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ ΠΊΠ²Π΅Ρ‚ΠΈΠ°ΠΏΠΈΠ½Π°

    ΠŸΠΎΠ»ΠΎΠ²Ρ‹Π΅ различия Π² клиничСских особСнностях антипсихотикиндуцированной Π³ΠΈΠΏΠ΅Ρ€ΠΏΡ€ΠΎΠ»Π°ΠΊΡ‚ΠΈΠ½Π΅ΠΌΠΈΠΈ Ρƒ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΡˆΠΈΠ·ΠΎΡ„Ρ€Π΅Π½ΠΈΠ΅ΠΉ

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    The goal was to identify gender differences in the clinical features of antipsychotic-induced hyperprolactinemia in patients with schizophrenia.Materials and methods. 98 patients from the Department of Endogenous Disorders of the Research Institute of Mental Health Clinic in Tomsk were examined. Persons aged 18–50 were included with followup treatment for at least 1 year, whose condition corresponded to the ICD-10 schizophrenia criteria. Prolactin levels were determined by ELISA using the PRL Test System reagent kit (MonobindInc., USA). The base map of sociodemographic and clinical-dynamic features for patients with schizophrenia was used. Statistical processing of data was performed using the Statistica 12.0 software package. Mann–Whitney U test, Pearson’s χ² criterion, including Yates correction, and Fisher’s two-sided test were used for comparing small samples.Results. The average serum concentration of prolactin in women was 52.4 Β± 39.1 ng/ml, in men it was 26.7 Β± 19.7 ng/ml. Hyperprolactinemia was detected in 23 (47.9%) women and 25 (50%) men. Among women with hyperprolactinemia, statistically significant β€œWeight Gain” and β€œHeadache” parameters were more common (p = 0.044 and p = 0.005, respectively). Men with hyperprolactinemia had higher BMI rates (p = 0.0066). For the rest of the UKU paragraphs, no significant differences were found in both men and women. Men presented fewer complaints and were less willing to discuss sexual dysfunction.Conclusion. Antipsychotic-induced hyperprolactinemia in patients with schizophrenia does not always have a full range of specific clinical manifestations and needs careful examination of patients with account of gender characteristics, as well as regular monitoring of the prolactin level in the serum of patients. ЦСль – выявлСниС ΠΏΠΎΠ»ΠΎΠ²Ρ‹Ρ… Ρ€Π°Π·Π»ΠΈΡ‡ΠΈΠΉ Π² клиничСских особСнностях антипсихотик-ΠΈΠ½Π΄ΡƒΡ†ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠΉ Π³ΠΈΠΏΠ΅Ρ€ΠΏΡ€ΠΎΠ»Π°ΠΊΡ‚ΠΈΠ½Π΅ΠΌΠΈΠΈ Ρƒ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΡˆΠΈΠ·ΠΎΡ„Ρ€Π΅Π½ΠΈΠ΅ΠΉ.ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. ΠžΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ‹ 98 Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΠΈΠ· отдСлСния эндогСнных расстройств ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΈ НИИ психичСского Π·Π΄ΠΎΡ€ΠΎΠ²ΡŒΡ Π³. Вомска. Π’ΠΊΠ»ΡŽΡ‡Π°Π»ΠΈΡΡŒ Π»ΠΈΡ†Π° 18–50 Π»Π΅Ρ‚ с Π΄Π°Π²Π½ΠΎΡΡ‚ΡŒΡŽ ΠΊΠ°Ρ‚Π°ΠΌΠ½Π΅Π·Π° заболСвания Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ 1 Π³ΠΎΠ΄Π°, состояниС ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… соотвСтствовало критСриям ΡˆΠΈΠ·ΠΎΡ„Ρ€Π΅Π½ΠΈΠΈ ΠΏΠΎ ΠœΠšΠ‘-10. ΠžΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΏΡ€ΠΎΠ»Π°ΠΊΡ‚ΠΈΠ½Π° ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΈΠΌΠΌΡƒΠ½ΠΎΡ„Π΅Ρ€ΠΌΠ΅Π½Ρ‚Π½Ρ‹ΠΌ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ с использованиСм Π½Π°Π±ΠΎΡ€Π° Ρ€Π΅Π°Π³Π΅Π½Ρ‚ΠΎΠ² PRL Test System (Monobind Inc., БША). ΠŸΡ€ΠΈΠΌΠ΅Π½ΡΠ»ΠΈΡΡŒ Базисная ΠΊΠ°Ρ€Ρ‚Π° социодСмографичСских ΠΈ клиникодинамичСских ΠΏΡ€ΠΈΠ·Π½Π°ΠΊΠΎΠ² для Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΡˆΠΈΠ·ΠΎΡ„Ρ€Π΅Π½ΠΈΠ΅ΠΉ, шкала UKU Π² Π°Π΄Π°ΠΏΡ‚ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠΉ русской вСрсии. Π‘Ρ‚Π°Ρ‚ΠΈΡΡ‚ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ ΠΎΠ±Ρ€Π°Π±ΠΎΡ‚ΠΊΡƒ ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ с использованиСм ΠΏΠ°ΠΊΠ΅Ρ‚Π° ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌ Statistica 12.0. ΠŸΡ€ΠΈΠΌΠ΅Π½ΡΠ»ΠΈ нСпарамСтричСский U-ΠΊΡ€ΠΈΡ‚Π΅Ρ€ΠΈΠΉ Манна – Π£ΠΈΡ‚Π½ΠΈ, χ² ΠŸΠΈΡ€ΡΠΎΠ½Π°, Π² Ρ‚ΠΎΠΌ числС с ΡƒΡ‡Π΅Ρ‚ΠΎΠΌ ΠΏΠΎΠΏΡ€Π°Π²ΠΊΠΈ ЙСйтса, для сравнСния ΠΌΠ°Π»Ρ‹Ρ… Π²Ρ‹Π±ΠΎΡ€ΠΎΠΊ Π±Ρ‹Π» использован двухсторонний ΠΊΡ€ΠΈΡ‚Π΅Ρ€ΠΈΠΉ Π€ΠΈΡˆΠ΅Ρ€Π°.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. Π‘Ρ€Π΅Π΄Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ ΠΊΠΎΠ½Ρ†Π΅Π½Ρ‚Ρ€Π°Ρ†ΠΈΠΈ ΠΏΡ€ΠΎΠ»Π°ΠΊΡ‚ΠΈΠ½Π° Π² сывороткС ΠΊΡ€ΠΎΠ²ΠΈ Ρƒ ΠΆΠ΅Π½Ρ‰ΠΈΠ½ зафиксированы Π½Π° ΡƒΡ€ΠΎΠ²Π½Π΅ (52,4 Β± 39,1) Π½Π³/ΠΌΠ», Ρƒ ΠΌΡƒΠΆΡ‡ΠΈΠ½ – (26,7 Β± 19,7) Π½Π³/ΠΌΠ». ГипСрпролактинСмия Π±Ρ‹Π»Π° выявлСна Ρƒ 23 (47,9%) ΠΆΠ΅Π½Ρ‰ΠΈΠ½ ΠΈ 25 (50%) ΠΌΡƒΠΆΡ‡ΠΈΠ½. Π£ ΠΆΠ΅Π½Ρ‰ΠΈΠ½ с Π³ΠΈΠΏΠ΅Ρ€ΠΏΡ€ΠΎΠ»Π°ΠΊΡ‚ΠΈΠ½Π΅ΠΌΠΈΠ΅ΠΉ статистичСски Π·Π½Π°Ρ‡ΠΈΠΌΠΎ Ρ‡Π°Ρ‰Π΅ Π²ΡΡ‚Ρ€Π΅Ρ‡Π°Π»ΠΈΡΡŒ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ Β«ΠΏΡ€ΠΈΠ±Π°Π²ΠΊΠ° Π² вСсС» ΠΈ «головная боль» (Ρ€ = 0,044 ΠΈ Ρ€ = 0,005 соотвСтствСнно), Ρƒ ΠΌΡƒΠΆΡ‡ΠΈΠ½ с Π³ΠΈΠΏΠ΅Ρ€ΠΏΡ€ΠΎΠ»Π°ΠΊΡ‚ΠΈΠ½Π΅ΠΌΠΈΠ΅ΠΉ – Π±ΠΎΠ»Π΅Π΅ высокиС ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ индСкса массы Ρ‚Π΅Π»Π° (p = 0,0066). По ΠΎΡΡ‚Π°Π»ΡŒΠ½Ρ‹ΠΌ ΠΏΡƒΠ½ΠΊΡ‚Π°ΠΌ UKU Π·Π½Π°Ρ‡ΠΈΠΌΡ‹Ρ… Ρ€Π°Π·Π»ΠΈΡ‡ΠΈΠΉ Π½Π΅ выявлСно ΠΊΠ°ΠΊ Ρƒ ΠΌΡƒΠΆΡ‡ΠΈΠ½, Ρ‚Π°ΠΊ ΠΈ Ρƒ ΠΆΠ΅Π½Ρ‰ΠΈΠ½. ΠœΡƒΠΆΡ‡ΠΈΠ½Ρ‹ ΠΏΡ€Π΅Π΄ΡŠΡΠ²Π»ΡΠ»ΠΈ мСньшСС количСство ΠΆΠ°Π»ΠΎΠ± ΠΈ Π±Ρ‹Π»ΠΈ ΠΌΠ΅Π½Π΅Π΅ доступны для обсуТдСния ΡΠ΅ΠΊΡΡƒΠ°Π»ΡŒΠ½ΠΎΠΉ дисфункции.Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. Антипсихотик-индуцированная гипСрпролактинСмия Ρƒ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΡˆΠΈΠ·ΠΎΡ„Ρ€Π΅Π½ΠΈΠ΅ΠΉ Π½Π΅ всСгда проявляСтся ΠΏΠΎΠ»Π½Ρ‹ΠΌ спСктром спСцифичСских клиничСских симптомов ΠΈ нуТдаСтся Π² Ρ‚Ρ‰Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠΌ обслСдовании ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с ΡƒΡ‡Π΅Ρ‚ΠΎΠΌ ΠΏΠΎΠ»Π°, Π° Ρ‚Π°ΠΊΠΆΠ΅ Π² рСгулярном ΠΌΠΎΠ½ΠΈΡ‚ΠΎΡ€ΠΈΠ½Π³Π΅ уровня ΠΏΡ€ΠΎΠ»Π°ΠΊΡ‚ΠΈΠ½Π° Π² сывороткС ΠΊΡ€ΠΎΠ²ΠΈ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ….

    Territory of sustainable development as a tool forΒ investmentΒ inΒ theΒ region

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    The article analyzes the causes of priority development territories (TOR), discussed the benefits provided by the state to residents of the top, highlighted the steps of forming the top. The territory of the advanced social and economic development is understood to be part of the territory of the subject of the Russian Federation, including a closed administrative and territorial formation, in which, in accordance with the decision of the Government of the Russian Federation, a special legal regime for the implementation of entrepreneurial and other activities is established to create favorable conditions for attracting investments, socio-economic development and the creation of comfortable conditions for the provision of livelihoods nosti population. The objectives of the creation of priority development areas are: the development of high-tech sectors of the economy, improving the competitiveness of the economy, creating new jobs and improving the quality of human resources, the alignment of the territorial imbalances, the production of new import-substituting and export-oriented products, and more. The need to attract investment to the territory, not only the problem of the Russian Federation regions and the country as a whole, has become another impetus for the creation of areas of advancing socio-economic development. For residents of the TOP, the following rights are provided: the right to release VAT from the duties of a taxpayer for 10 years from the date of obtaining the status of a TOP resident; establishment of a zero VAT rate in respect of goods (works, services) imported to the TOP for use by TOP residents; use of accelerated depreciation on the objects of depreciable property belonging to them; a lowered rate of corporate income tax. Thanks to the above measures, the cost reduction of business will be from 40%, which will be a huge incentive for business opening in the territories of Eastern Siberia and the Far East

    PSYCHOMETRIC EVALUATION OF SYMPTOMS AND CLINICAL DYNAMICS OF SCHIZOPHRENIA IN DEPENDING ON CONSTITUTIONALLY-MORPHOLOGICAL TYPE OF THE PATIENTS

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    The purpose of this study was to research the psychometrical parameters and the clinical-dynamic features of patients with schizophrenia in depending on their constitutionally-morphological type.Material and methods. The examination of 86 patients with schizophrenia who are hospitalized at Department of endogenous mental disorders of Mental Health Research Institute was conducted. The study included patients of age from 18 to 65 years old with prescription of catamnesis at least 1 year and whose state at the time of examination corresponded to the diagnostic criteria for schizophrenia from the ICD-10 (International Classification of Diseases 10th Revision). The examination included filling in a modified version of Basic Card of Standardized Description of the Patient with Schizophrenia and his Relative, Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression Scale (CGI). In addition to that patients were examined using anthropometrical method by V.V. Bunak. Statistical significance of differences in the data was evaluated using the Kruskal – Wallis test by ranks, the Mann – Whitney U-test, and Pearson’s chi-squared test. The correlation analysis was performed by the Spearman’s rank correlation test. The K-Means Cluster Analysis was used to determine of the qualitative interrelation and conjugation between the clinical characteristics of the examined.The results of the study revealed that many parameters of the functioning in these patient groups have statistically significant differences. Use of the K-Means Cluster Analysis was allowed to reveal the internal structure of the data, to group the individual observations according to their degree of similarity.Conclusions. The obtained data leads to the assumption that the constitutionally-morphological type of patients has an impact on the clinical course of schizophrenia, as well as their adaptation abilities. Asthenic constitutionally-morphological type is a factor of adverse clinical dynamic of schizophrenia and associates with persistent negative disorders and suicidal actions. Overall, this study continues integrative anthropological trend in psychiatry and lays the foundation for further study of the constitutional factors effect on the course of schizophrenia. The obtained results can serve as a model for studying the facade symptoms in general schizophrenia spectrum disorders and be used in the development of individually oriented therapeutic and rehabilitation programs in clinical psychiatry

    Sexual differences in the clinical features of antipsychotic-induced hyperprolactinemia in patients with schizophrenia

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    The goal was to identify gender differences in the clinical features of antipsychotic-induced hyperprolactinemia in patients with schizophrenia.Materials and methods. 98 patients from the Department of Endogenous Disorders of the Research Institute of Mental Health Clinic in Tomsk were examined. Persons aged 18–50 were included with followup treatment for at least 1 year, whose condition corresponded to the ICD-10 schizophrenia criteria. Prolactin levels were determined by ELISA using the PRL Test System reagent kit (MonobindInc., USA). The base map of sociodemographic and clinical-dynamic features for patients with schizophrenia was used. Statistical processing of data was performed using the Statistica 12.0 software package. Mann–Whitney U test, Pearson’s χ² criterion, including Yates correction, and Fisher’s two-sided test were used for comparing small samples.Results. The average serum concentration of prolactin in women was 52.4 Β± 39.1 ng/ml, in men it was 26.7 Β± 19.7 ng/ml. Hyperprolactinemia was detected in 23 (47.9%) women and 25 (50%) men. Among women with hyperprolactinemia, statistically significant β€œWeight Gain” and β€œHeadache” parameters were more common (p = 0.044 and p = 0.005, respectively). Men with hyperprolactinemia had higher BMI rates (p = 0.0066). For the rest of the UKU paragraphs, no significant differences were found in both men and women. Men presented fewer complaints and were less willing to discuss sexual dysfunction.Conclusion. Antipsychotic-induced hyperprolactinemia in patients with schizophrenia does not always have a full range of specific clinical manifestations and needs careful examination of patients with account of gender characteristics, as well as regular monitoring of the prolactin level in the serum of patients

    Molecular-Genetic and Epidemiologic Examination of Personnel Subjected to Occupational Irradiation

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    It is given an evaluation of the genetic polymorphisms (Hp, Tf, Gc; 6-PGD, EsD, ACP, PGM1, microsatellite loci CSF1PO ΠΈ F13AO1, detoxicating genes GSTT1, GSTM1 and GSTP1), individual radiosensitivity (by the criterion of ribosome gene fragments) and DNA-damage rate (Comet-assay) in two cohorts comprised by VNIIEF personnel subjected chronically to gamma-neutron ionizing radiation and to Ξ²-radiation of Tritium in comparison with the effects in non-irradiated cohort. There are discussed data on the influence of the occupational irradiation, age and genotype on the rate of structural genome damage, as well as on the activity of the human repair system activity and health status
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