31 research outputs found

    Structural features of the Sierra Pampeana de Velasco and surrounding areas from gravimetric and magnetometric fields

    Get PDF
    La regi√≥n que comprende la sierra de Velasco y el Sistema de Famatina, en el centro-oeste de la Provincia de La Rioja - Argentina, es un √°rea clave para el estudio de la amalgamaci√≥n de terrenos y tect√≥nica vinculada con el levantamiento andino. En √©ste trabajo, se definen algunos rasgos de la estructura cortical de √©sta regi√≥n. Para ello, mediante la aplicaci√≥n de m√©todos potenciales(gravedad y magnetismo), adecuadamente procesados e interpretados a trav√©s de t√©cnicas semiautom√°ticas y de resalto de anomal√≠as, se logr√≥ determinar: a) una regi√≥n que responder√≠a a la zona de sutura entre los terrenos Famatina y Pampia y b) fallas relacionadas al levantamiento de las sierras de Famatina y de Velasco. Los resultados anteriores se representan en una secci√≥n este - oeste en un modelo estructural de bloques de basamento entre Famatina y Velasco, hasta 12 km de profundidad. En √©l se√Īalamos adem√°s la distribuci√≥n de las fallas y sus buzamientos.The region comprising the Sierra de Velasco and Famatina System, in the center-west of the province of La Rioja in Argentina, is a key area for the study of the tectonic amalgamation of land and linked to the Andean uplift. In this paper, we define some features of the crustal structure of this region. To do this, by applying potential methods (gravity and magnetics), properly processed and interpreted through semiautomatic techniques and rib anomalies, it was determined: a) a region that respond to the suture zone between Famatina and Pampia Terrain b) faults related to the uplift of the Sierras de Famatina and Velasco. The above results are represented in a section east - west in a structural model of basement blocks between Famatina and Velasco, up to 12 km deep. It also noted the distribution of faults and dips.Fil: Sanchez, Marcos Ariel. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Fisicas y Naturales. Instituto Geofisico Sismologico Volponi; Argentina. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas; ArgentinaFil: Spagnotto, Silvana Liz. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas; Argentina. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Fisicas y Naturales. Instituto Geofisico Sismologico Volponi; ArgentinaFil: Martinez, Myriam Patricia. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Fisicas y Naturales. Instituto Geofisico Sismologico Volponi; Argentina. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas; Argentin

    Docentes y literatura: La experiencia de lectura como punto de reflexión

    Get PDF
    Este trabajo presenta la puesta en marcha de una propuesta que busca promover y desarrollar, en un grupo de docentes, espacios de reflexión en torno a la práctica de lectura de la literatura en el proceso de formación docente. En esta iniciativa se considera que es necesario darle un sentido más amplio a la lectura de la literatura en la escuela, reflexionar sobre la manera como se propone y desarrolla la lectura en el aula y revisar la influencia que tiene la experiencia de lectura del docente en las formas de trabajar un texto literario con sus estudiantes.Abstract. This paper presents the implementation of a proposal that seeks to promote and develop opportunities for reflection in a group of teachers on the reading practice of literature in the teacher education process. This initiative is considered necessary to give a broader sense to the reading of literature in school, reflect on how it proposes and develops classroom reading and review the influence of the teacher’s reading experience in ways of working on a literary text with the students.Maestrí

    Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians

    Get PDF
    A recent genetic association study has identified a microsatellite in the coding sequence of the asporin gene as a susceptibility factor for osteoarthritis (OA). Alleles of this microsatellite determine the variable number of aspartic acid residues in the amino-terminal end of the asporin protein. Asporin binds directly to the growth factor transforming growth factor beta and inhibits its anabolic effects in cartilage, which include stimulation of collagen and aggrecan synthesis. The OA-associated allele, with 14 aspartic acid residues, inhibits the anabolic effects of transforming growth factor beta more strongly than other asporin alleles, leading to increased OA liability. We have explored whether the association found in several cohorts of Japanese hip OA and knee OA patients was also present in Spanish Caucasians. We studied patients that had undergone total joint replacement for primary OA in the hip (n = 303) or the knee (n = 188) and patients with hand OA (n = 233), and we compared their results with controls (n = 294) lacking overt OA clinical symptoms. No significant differences were observed in any of the multiple comparisons performed, which included global tests of allele frequency distributions and specific comparisons as well as stratification by affected joint and by sex. Our results, together with reports from the United Kingdom and Greece, indicate that the stretch of aspartic acid residues in asporin is not an important factor in OA susceptibility among European Caucasians. It remains possible that lifestyle, environmental or genetic differences allow for an important effect of asporin variants in other ethnic groups as has been reported in the Japanese, but this should be supported by additional studies

    Seismic-gravimetric analysis of the subducted Nazca plate 1 between 32¬įS and 36¬įS

    Get PDF
    The study region is seismically and tectonically characterized by the angle variations in the subduction of the Nazca plate. The results obtained from earthquakes location between 32¬į and 36¬įS latitude and 67¬į‚Äď71¬įW longitude are presented in this work. The presence of a wedge of asthenospheric materials and the partial or total eclogitization of the subducted Nazca plate and its relation with isostatic cortex models published was analyzed. In addition, a gravimetric profile obtained from gravity forward modeling is presented at 33.5¬įS, proposing a new configuration at depths for the main tectonic components: Nazca plate, asthenospheric wedge and South American plate. Also, a new density scheme using recently published velocity models was obtained.Fil: Eckerman, Mar√≠a Luj√°n. Universidad Nacional de San Luis; ArgentinaFil: Ag√ľero, Alejo. YPF - Tecnolog√≠a; ArgentinaFil: Spagnotto, Silvana Liz. Universidad Nacional de San Luis. Facultad de Ciencias F√≠sico Matem√°ticas y Naturales. Departamento de Geolog√≠a; Argentina. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas. Centro Cient√≠fico Tecnol√≥gico Conicet - San Luis; ArgentinaFil: Mart√≠nez, Myriam Patricia. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, F√≠sicas y Naturales. Instituto Geof√≠sico Sismol√≥gico Volponi; Argentina. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas. Centro Cient√≠fico Tecnol√≥gico Conicet - San Juan; ArgentinaFil: Nacif Suvire, Silvina Valeria. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, F√≠sicas y Naturales. Instituto Geof√≠sico Sismol√≥gico Volponi; Argentina. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas. Centro Cient√≠fico Tecnol√≥gico Conicet - San Juan; Argentin

    Crustal structure and tectonic setting of the south central Andes from gravimetric analysis

    Get PDF
    En el presente trabajo, a partir de datos gravimétricos terrestres, se preparó una carta de anomalías de Bouguer, la cual fue adecuadamente filtrada a fin de separar efectos gravimétricos someros y profundos. Con base en un modelo de densidad, mediante de técnicas de inversión gravimétrica, se modeló la discontinuidad corteza-manto y el basamento cristalino, respectivamente. De forma posterior, se evaluó el espesor elástico equivalente considerando la información de la discontinuidad de la corteza-manto y la carga topográfica. Se encontraron valores altos de espesor elástico Te, al este de la precordillera Andina y al oeste de la sierra Pampeana de Velasco. Estos resultados son consistentes con los valores positivos de anomalía residual de Bouguer e isotáticos, lo que estaría indicando la presencia de rocas de alta densidad en corteza media a superior. Además, los análisis petrográficos y geoquímicos realizados en afloramientos en superficie indican un origen mantélico.Fil: Weidmann, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto Geofísico Sismológico Volponi; ArgentinaFil: Spagnotto, Silvana Liz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Departamento de Geología; ArgentinaFil: Gimenez, Mario Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Fisicas y Naturales. Instituto Geofisico Sismologico Volponi; ArgentinaFil: Martinez, Myriam Patricia. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Fisicas y Naturales. Instituto Geofisico Sismologico Volponi; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Alvarez Pontoriero, Orlando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto Geofísico Sismológico Volponi; ArgentinaFil: Sanchez, Marcos Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto Geofísico Sismológico Volponi; ArgentinaFil: Lince Klinger, Federico Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto Geofísico Sismológico Volponi; Argentin

    Premio a la investigación e innovación educativa : experiencias 2020

    Get PDF
    Con el presente libro, la Secretar√≠a de Educaci√≥n del Distrito y el Instituto para la Investigaci√≥n Educativa y el Desarrollo Pedag√≥gico, ofrecen a la ciudadan√≠a 10 textos que recogen el trabajo arduo y comprometido de los maestros y las maestras de la ciudad, ganadores de la XIV versi√≥n del Premio a la Investigaci√≥n e Innovaci√≥n Educativa. Las propuestas son muestra del buen camino que est√° recorriendo la educaci√≥n de Bogot√°, en las m√°s variadas disciplinas y campos del conocimiento, como los relacionados con el medio ambiente, la inclusi√≥n, la tecnolog√≠a, la ciudadan√≠a y la convivencia, el arte, y los procesos de ense√Īanza-aprendizaje en distintas √°reas, entre otros

    The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

    Get PDF
    Abstract: Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM‚ąí/‚ąí patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors

    The genetic architecture of the human cerebral cortex

    Get PDF
    The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

    Large expert-curated database for benchmarking document similarity detection in biomedical literature search

    Get PDF
    Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe
    corecore