Facile Synthesis of Amorphous MnO_x Catalysts for Efficient Ozone Elimination in Domestic Refrigerators

Amorphous manganese oxide catalysts, aimed at efficient ozone removal in refrigerators, were synthesized using a simple redox method. Factors like crystallinity of structure, textural properties, and Fe doping significantly affect the catalyst’s performance. The Fe-doped KMF-250 showcased outstanding ozone decomposition capabilities, efficiently eliminating 10,000 ppb of ozone at an average rate of ca. 13.3 , under conditions of 6 °C and 36% relative humidity in a refrigerator chamber (144 L). Moreover, this catalyst exhibits extraordinary stability, outperforming existing commercial catalysts in terms of both durability and efficiency. The incorporation of even a minimal amount of Fe (0.84 wt%) considerably raised the amount of low-valence Mn, resulting in more crystal defects and oxygen vacancies. The existence of Fe in MnOx was also found playing an important role in promoting the desorption of the oxygen species and enhancing the oxygen mobility to generate oxygen vacancies, both of which contribute to the quick recovery of the catalyst. The catalyst’s large specific surface area, combined with optimal Fe doping, are crucial for its superior catalytic performance. This research delivers a potent MnOx catalyst suitable for ozone removal in refrigerators and viable for mass production.</p

Additional file 1 of Sacubitril/valsartan inhibits the proliferation of vascular smooth muscle cells through notch signaling and ERK1/2 pathway

Supplementary Material

Synthesis Mechanism Study of Layered Double Hydroxides Based on Nanoseparation

Colloidal layered double hydroxides (LDH) nanosheets were sorted by their lateral sizes using a density gradient ultracentrifuge separation technique. Composition investigations on these size-sorted nanosheets indicated that larger sheets had higher Mg:Al ratio than the smaller ones. Experiments using different Mg:Al feed ratios confirmed that high Mg:Al ratio induced fast sheet growth speed. Tracking the source of the Mg:Al spatial distribution difference in one batch of synthesis at the nucleation process revealed the coprecipitation-redissolution of Mg²⁺. Thus the discriminative separation of these nanosheets led to a new insight into the structure-composition relationship of LDH nanomaterials and more understanding on their formation mechanism

A Structured Catalyst toward Mercaptan Sweetening with Largely Enhanced Synergistic Effect

A structured catalyst has been fabricated by immobilizing cobalt phthalocyanine tetrasulfonate (CoPcS) on a MgNiAl mixed metal oxide (MgNiAl-MMO) film derived from calcination of layered double hydroxide (LDH). The resulting CoPcS/MgNiAl-MMO catalyst exhibits excellent activity, stability, and recyclability for the reaction of mercaptan sweetening. SEM images show that the structured catalyst is composed of thin MMO nanoflakes perpendicular to the Al substrate. The synergistic effect between the oxidation center (CoPcS) and the abundant moderate basic sites on the surface of the MgNiAl-MMO substrate plays an important role in the sweetening process, accounting for the largely enhanced catalytic behavior (conversion: 92.8%; selectivity: 100%). In addition, the structured catalyst exhibits superior catalysis regeneration performance, owing to its specific architecture and strong mechanical stability. This work demonstrates a facile approach for modulating the synergistic effect between the active center and the basicity for the structured catalyst, for the purpose of achieving largely enhanced catalytic behavior in the petroleum refining industry

Durable Immunomodulatory Nanofiber Niche for the Functional Remodeling of Cardiovascular Tissue

Functional remodeling and prolonged anti-inflammatory responses are both vital for repairing damage in the cardiovascular system. Although these aspects have each been studied extensively alone, attempts to fabricate scaffolds that combine these effects have seen limited success. In this study, we synthesized salvianic acid A (SA, danshensu) blocked biodegradable polyurethane (PCHU-D) and enclosed it within electrospun nanofibers to synthesize a durable immunomodulatory nanofiber niche (DINN), which provided sustained SA release during inflammation. Given its excellent processability, mechanical properties, and shape memory function, we developed two variants of the DINN as vascular scaffolds and heart patches. Both these variants exhibited outstanding therapeutic effects in in vivo experiments. The DINN was expertly designed such that it gradually decomposes along with SA release, substantially facilitating cellular infiltration and tissue remodeling. Therefore, the DINN effectively inhibited the migration and chemotaxis of inflammatory cells, while also increasing the expression of angiogenic genes. As a result, it promoted the recovery of myocardial function after myocardial infarction and induced rapid reendothelialization following arterial orthotopic transplantation repair. These excellent characteristics indicate that the DINN holds great potential as a multifunctional agent for repairing cardiovascular tissues

Durable Immunomodulatory Nanofiber Niche for the Functional Remodeling of Cardiovascular Tissue

Functional remodeling and prolonged anti-inflammatory responses are both vital for repairing damage in the cardiovascular system. Although these aspects have each been studied extensively alone, attempts to fabricate scaffolds that combine these effects have seen limited success. In this study, we synthesized salvianic acid A (SA, danshensu) blocked biodegradable polyurethane (PCHU-D) and enclosed it within electrospun nanofibers to synthesize a durable immunomodulatory nanofiber niche (DINN), which provided sustained SA release during inflammation. Given its excellent processability, mechanical properties, and shape memory function, we developed two variants of the DINN as vascular scaffolds and heart patches. Both these variants exhibited outstanding therapeutic effects in in vivo experiments. The DINN was expertly designed such that it gradually decomposes along with SA release, substantially facilitating cellular infiltration and tissue remodeling. Therefore, the DINN effectively inhibited the migration and chemotaxis of inflammatory cells, while also increasing the expression of angiogenic genes. As a result, it promoted the recovery of myocardial function after myocardial infarction and induced rapid reendothelialization following arterial orthotopic transplantation repair. These excellent characteristics indicate that the DINN holds great potential as a multifunctional agent for repairing cardiovascular tissues

Durable Immunomodulatory Nanofiber Niche for the Functional Remodeling of Cardiovascular Tissue

Functional remodeling and prolonged anti-inflammatory responses are both vital for repairing damage in the cardiovascular system. Although these aspects have each been studied extensively alone, attempts to fabricate scaffolds that combine these effects have seen limited success. In this study, we synthesized salvianic acid A (SA, danshensu) blocked biodegradable polyurethane (PCHU-D) and enclosed it within electrospun nanofibers to synthesize a durable immunomodulatory nanofiber niche (DINN), which provided sustained SA release during inflammation. Given its excellent processability, mechanical properties, and shape memory function, we developed two variants of the DINN as vascular scaffolds and heart patches. Both these variants exhibited outstanding therapeutic effects in in vivo experiments. The DINN was expertly designed such that it gradually decomposes along with SA release, substantially facilitating cellular infiltration and tissue remodeling. Therefore, the DINN effectively inhibited the migration and chemotaxis of inflammatory cells, while also increasing the expression of angiogenic genes. As a result, it promoted the recovery of myocardial function after myocardial infarction and induced rapid reendothelialization following arterial orthotopic transplantation repair. These excellent characteristics indicate that the DINN holds great potential as a multifunctional agent for repairing cardiovascular tissues

Lrp5 coexpression enhances glucagon and GLP1-induced β-catenin signaling.

<p>A). HEK293 cells cultured in 12-well plate were transfected with a combination of indicated plasmids (GCGR 1000 ng, Lrp5 500 ng) for 24 h and then treated with or without 50 nM GCG1-29 for 1 h. The cells were harvested and lysed, and samples were used for western blot analysis. The blot was first probed with anti-β-catenin antibody and then stripped and reprobed for anti-β-actin antibody as a loading control. B). 293STF cells cultured in 24-well plate were transfected with 100 ng of empty vector (pcDNA3.1) or GCGR plasmid along with the indicated amount of Lrp5 and 5 ng TKRlu plasmids on day 1, and then treated with or without 50 nM GCG1-29 on day 2. Cells were harvested for luciferase activity measurement on day 3. Triplicate samples were used for each treatment. *p<0.005 compared with non-treated group. 4C). 293STF cells cultured in 24-well plate were transfected with 100 ng GLP1R, 100 ng Lrp5 and 5 ng TKRlu plasmids on day 1 and then treated with the GLP1 agonist GLP1(7–36) (50 nM) or the antagonist Exendin(9–39) (50 nM) on day 2. Cells were harvested on day 3 to measure luciferase activity. Duplicate samples were used for each treatment. *p<0.05 compared with the non-treated (NT) group.</p

Pyroelectric Synthesis of Metal–BaTiO₃ Hybrid Nanoparticles with Enhanced Pyrocatalytic Performance

This paper presents a pyroelectric approach for the synthesis of metal–BaTiO3 hybrid nanoparticles (NPs) and demonstrates the enhanced performance on the degradation of dye solution using such hybrid NPs. During the synthesis process, rapid temperature oscillation accelerated the electron generation at the surface of pyroelectric barium titanate (BTO) NPs that were dispersed in either aqueous or nonaqueous solutions. These generated electrons were used to reduce the metal salts on the surface of BTO NPs without the need for a reducing reagent. The Au–BTO hybrid NPs synthesized by such approach showed higher pyrocatalytic degradation efficiency for dye solution than the physically mixed solutions of Au NPs and BTO NPs. Compared to conventional processes, this pyrocatalytic approach without the need for additional reducing reagents not only offers an alternative strategy for the synthesis of metal–pyroelectric hybrid materials but also opens a new way to harvest thermal energy for efficient pyrocatalysis process

Glucagon-induced β-catenin signaling is dependent on PKA activity.

<p>A). 293STF cells cultured in 24-well plate were transfected with 100 ng GCGR and 5 ng TKRlu plasmids on day 1 and then treated with GCG1-29 (50 nM), GCG9-29 (50 nM), or GCG1-29 (50 nM) and PKA inhibitor H89 (10 µM) on day 2. Cells were harvested on day 3 to measure the TCF-mediated luciferase activity. Triplicate samples were used for each treatment. *p<0.005 compared with the non-treated group. ^#p<0.005 compared with GCG1-29-treated group. B). 293STF cells cultured in 24-well plate were transfected with 100 ng GCGR, 100 ng Lrp5 and 5 ng TKRlu plasmids on day 1 and then treated with GCG1-29, H89, or both on day 2. Cells were harvested on day 3 to measure the TCF-mediated luciferase activity. Duplicate samples were used for each treatment. *p<0.02 compared with the non-treated (NT) group. ^#p<0.005 compared with GCG1-29-treated group.</p