Meta-analysis of PRL-3 overexpression and prognosis in gastric cancer patients.

<p>All pooled <i>HR</i><b><i>s</i></b> were derived from random-effect model.</p><p><i>P</i>_h<i>P</i>-value for heterogeneity based on <b><i>Q</i></b> test.</p><p><i>P P</i>-value for statistical significance based on <b><i>Z</i></b> test.</p

Flow diagram of the study selection process and specific reasons for exclusion in the meta-analysis.

<p>Flow diagram of the study selection process and specific reasons for exclusion in the meta-analysis.</p

Poor Prognosis of Phosphatase of Regenerating Liver 3 Expression in Gastric Cancer: A Meta-Analysis

<div><p>Background</p><p>Overexpression of phosphatase of regenerating liver 3 (PRL-3) has been implicated in gastric cancer (GC) metastasis. Epidemiological studies have evaluated the relationship between PRL-3 expression and prognosis in GC. However, results still remains controversial. In this study, a meta-analysis was performed to evaluate the association of PRL-3 expression with overall survival (OS) and clinicopathological characteristics.</p><p>Methods</p><p>Literature databases were searched to identify eligible studies dated until April 2013. Summary hazard ratios (HRs) or odds ratios (ORs) with 95% confidence interval (95% CI) were calculated to estimate the association.</p><p>Results</p><p>A total of 1380 GC patients from six studies were included in the meta-analysis. Overall, the combined HR estimate for OS in a random-effect model was 1.89 (95% CI = 1.38–2.60; <i>P</i><0.001). Results showed that PRL-3 overexpression was significantly associated with OS, indicating that it may be a biomarker for poor prognosis of GC. Both subgroup and sensitivity analyses further identified the prognostic role of PRL-3 expression in GC patients. Moreover, PRL-3 overexpression was significantly associated with tumor stage (OR = 2.25; 95% CI = 1.63–3.12; <i>P</i><0.001), depth of invasion (OR = 2.03; 95% CI = 1.38–2.98; <i>P</i><0.001), vascular invasion (OR = 2.52; 95% CI = 1.79–3.56; <i>P</i><0.001), lymphatic invasion (OR = 3.74; 95% CI = 2.49–5.63; <i>P</i><0.001), and lymph node metastasis (OR = 4.56; 95% CI = 2.37–8.76; <i>P</i><0.001). However, when age, sex, tumor size, and tumor differentiation were considered, no obvious association was observed.</p><p>Conclusions</p><p>This meta-analysis reveals significant association of PRL-3 overexpression with OS and some clinicopathological features in GC. PRL-3 may be a predicative factor of poor prognosis and aggressive tumor behavior in GC patients.</p></div

The forest plot for the overall association between PRL-3 overexpression and OS of GC patients.

<p>The contribution of each study to the meta-analysis (its weight) is represented by the <i>area</i> of a <i>box</i>, the <i>center</i> of which represents the size of the HR estimated from that study. The 95% CI for the HR (<i>extending lines</i>) from each study is also shown. The pooled HR is shown in the <i>middle</i> of a <i>diamond</i>, the <i>left</i> and <i>right</i> extremes of which represent the corresponding CI.</p

Flow diagram of study selection and specific reasons for exclusion in the meta-analysis.

<p>Flow diagram of study selection and specific reasons for exclusion in the meta-analysis.</p

The pooled AUC and 95% CI after omitting each trial in the meta-analysis (The results of sensitivity analysis).

<p>^a Results of first of two trials in this article</p><p>^b Results of second of two trials in this article</p><p>AUC: the area under the summary receiver operating characteristic curve; CI: confidence interval.</p><p>The pooled AUC and 95% CI after omitting each trial in the meta-analysis (The results of sensitivity analysis).</p

Main characteristic of 6 eligible studies enrolled in this meta-analysis.

<p><i>NR</i> data were not reported, <i>NS</i> not significant, <i>ISH</i> in situ hybridization, <i>IHC</i> immunohistochemistry,</p>a<p>directly extracted from original data,</p>b<p>extrapolated from survival curve.</p

The diagnostic parameters of presepsin for sepsis in the included trials, and overall outcome.

<p>^a Results of first of two trials in this article</p><p>^b Results of second of two trials in this article</p><p>TP: true positive; FP: false positive; FN: false negative; TN: true negative; Se: sensitivity; Sp: specificity; PLR: positive likelihood ratio; NLR: negative likelihood ratio; DOR: diagnostic odds ratio.</p><p>The diagnostic parameters of presepsin for sepsis in the included trials, and overall outcome.</p

Meta-analysis of the association between the 3801T>C polymorphism of CYP1A1 and risk for idiopathic male infertility under homozygous model.

<p>The contribution of each study to the meta-analysis (its weight) is represented by the area of a box, the center of which represents the size of the OR estimated from that study. The 95% CI for the OR (extending lines) from each study is also shown. The overall OR is shown in the middle of a diamond, the left and right extremes of which represent the corresponding CI.</p

Association between 3801T>C Polymorphism of CYP1A1 and Idiopathic Male Infertility Risk: A Systematic Review and Meta-Analysis

<div><p>Background</p><p>Epidemiological studies have evaluated the association between 3801T>C polymorphism of CYP1A1 gene and the risk for idiopathic male infertility, but the results are inconclusive. We aimed to derive a more precise estimation of the relationship by conducting a meta-analysis of case-control studies.</p><p>Methods</p><p>This study conformed to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Embase and CNKI databases were searched through November 2013 to identify relevant studies. Pooled odds ratios with 95% confidence intervals were used to assess the strength of the association between CYP1A1 3801T>C polymorphism and idiopathic male infertility risk. <i>Q</i>-test was performed to evaluate between-study heterogeneity and publication bias was appraised using funnel plots. Sensitivity analyses were conducted to evaluate the robustness of meta-analysis findings.</p><p>Results</p><p>Six studies involving 1,060 cases and 1,225 controls were included in this meta-analysis. Overall, significant associations between 3801T>C polymorphism and idiopathic male infertility risk were observed in allelic comparison (OR = 1.36, 95% CI: 1.01–1.83), homozygous model (OR = 2.18, 95% CI: 1.15–4.12), and recessive model (OR = 1.86, 95% CI: 1.09–3.20), with robust findings according to sensitivity analyses. However, subgroup analyses did not further identify the susceptibility to idiopathic male infertility in all comparisons. Funnel plot inspections did not reveal evidence of publication bias.</p><p>Conclusions</p><p>The current meta-analysis provides evidence of a significant association between CYP1A1 3801T>C polymorphism and idiopathic male infertility risk. Considering the limitation inherited from the eligible studies, further confirmation in large-scale and well-designed studies is needed.</p></div