Analysis of a discrete-layout bimorph disk elements piezoelectric deformable mirror

We introduce a discrete-layout bimorph disk elements piezoelectric deformable mirror (DBDEPDM), driven by the circular flexural-mode piezoelectric actuators. We formulated an electromechanical model for analyzing the performance of the new deformable mirror. As a numerical example, a 21-actuators DBDEPDM with an aperture of 165 mm was modeled. The presented results demonstrate that the DBDEPDM has a stroke larger than 10  μm and the resonance frequency is 4.456 kHz. Compared with the conventional piezoelectric deformable mirrors, the DBDEPDM has a larger stroke, higher resonance frequency, and provides higher spatial resolution due to the circular shape of its actuators. Moreover, numerical simulations of influence functions on the model are provided

Non-Hermitian skin effect in a single trapped ion

Non-Hermitian skin effect (NHSE) describes the exponential localization of all eigenstates toward boundaries in non-Hermitian systems, and has attracted intense research interest of late. Here we theoretically propose a scheme in which the NHSE significantly impacts the external motion of a single trapped ion through complex spin-motion dynamics. On the one hand, we show the competition between the NHSE and the coherent Bloch dynamics. On the other hand, since the NHSE manifests as a non-reciprocal flow in occupied phonon modes, we demonstrate that such dynamics can have potential applications in cooling and sensing. Our proposal can be readily implemented using existing experimental techniques, and offers a scalable (in terms of the available ions and phonon modes) simulation platform for relevant non-Hermitian physics.Comment: 9 pages, 8 figure

Characterization of enhancers and the role of the transcription factor KLF7 in regulating corneal epithelial differentiation

During tissue development, transcription factors bind regulatory DNA regions called enhancers, often located at great distances from the genes they regulate, to control gene expression. The enhancer landscape during embryonic stem cell differentiation has been well characterized. By contrast, little is known about the shared and unique enhancer regulatory mechanisms in different ectodermally derived epithelial cells. Here we use ChIP sequencing (ChIP-seq) to identify domains enriched for the histone marks histone H3 lysine 4 trimethylation, histone H3 lysine 4 monomethylation, and histone H3 lysine 27 acetylation (H3K4me3, H3K4me1, and H3K27ac) and define, for the first time, the super enhancers and typical enhancers active in primary human corneal epithelial cells. We show that regulatory regions are often shared between cell types of the ectodermal lineage and that corneal epithelial super enhancers are already marked as potential regulatory domains in embryonic stem cells. Kruppel-like factor (KLF) motifs were enriched in corneal epithelial enhancers, consistent with the important roles of KLF4 and KLF5 in promoting corneal epithelial differentiation. We now show that the Kruppel family member KLF7 promotes the corneal progenitor cell state; on many genes, KLF7 antagonized the corneal differentiation-promoting KLF4. Furthermore, we found that two SNPs linked previously to corneal diseases, astigmatism, and Stevens-Johnson syndrome fall within corneal epithelial enhancers and alter their activity by disrupting transcription factor motifs that overlap these SNPs. Taken together, our work defines regulatory enhancers in corneal epithelial cells, highlights global gene-regulatory relationships shared among different epithelial cells, identifies a role for KLF7 as a KLF4 antagonist in corneal epithelial cell differentiation, and explains how two SNPs may contribute to corneal diseases

Interfollicular Epidermal Differentiation is Gradualistic Rather than Stepwis with GRHL3 Controlling Progression from Stem to Transition Cell States

Although interfollicular epidermal (IFE) differentiation is thought to bestepwise as reflected in sharp boundaries between the basal, spinous, granularand cornified layers, this prediction has not been studied at a single cellresolution. We used single cell RNA-seq to show that IFE differentiation is bestdescribed as a single step gradualistic process with a large number of transitioncells between the basal and spinous layer. RNA-velocity analysis identifies acommitment point that separates the plastic basal and transition cell state fromthe unidirectionally differentiating cells. We also show that GRHL3, best knownfor promoting IFE terminal differentiation, has a major function in suppressingepidermal stem cell expansion and the emergence of an abnormal stem cell stateby suppressing Wnt signaling in stem cells

Interfollicular Epidermal Differentiation is Gradualistic Rather than Stepwis with GRHL3 Controlling Progression from Stem to Transition Cell States

Although interfollicular epidermal (IFE) differentiation is thought to bestepwise as reflected in sharp boundaries between the basal, spinous, granularand cornified layers, this prediction has not been studied at a single cellresolution. We used single cell RNA-seq to show that IFE differentiation is bestdescribed as a single step gradualistic process with a large number of transitioncells between the basal and spinous layer. RNA-velocity analysis identifies acommitment point that separates the plastic basal and transition cell state fromthe unidirectionally differentiating cells. We also show that GRHL3, best knownfor promoting IFE terminal differentiation, has a major function in suppressingepidermal stem cell expansion and the emergence of an abnormal stem cell stateby suppressing Wnt signaling in stem cells

Realism of modelled Indian summer monsoon correlation with the tropical Indo-Pacific affects projected monsoon changes

AbstractEl Niño-Southern Oscillation (ENSO) and the Indian Ocean Dipole (IOD) tend to exert an offsetting impact on Indian summer monsoon rainfall (ISMR), with an El Niño event tending to lower, whereas a positive IOD tending to increase ISMR. Simulation of these relationships in Phase Five of the Coupled Model Intercomparison Project has not been fully assessed, nor is their impact on the response of ISMR to greenhouse warming. Here we show that the majority of models simulate an unrealistic present-day IOD-ISMR correlation due to an overly strong control by ENSO. As such, a positive IOD is associated with an ISMR reduction in the simulated present-day climate. This unrealistic present-day correlation is relevant to future ISMR projection, inducing an underestimation in the projected ISMR increase. Thus uncertainties in ISMR projection can be in part induced by present-day simulation of ENSO, the IOD, their relationship and their rainfall correlations.</jats:p

Three Vectors Model Predictive Torque Control Without Weighting Factor Based on Electromagnetic Torque Feedback Compensation

Finite control set-model predictive torque control (FCS-MPTC) depends on the system parameters and the weight coefficients setting. At the same time, since the actual load disturbance is unavoidable, the model parameters are not matched, and there is a torque tracking error. In traditional FCS-MPTC, the outer loop—that is, the speed loop—adopts a classic Proportional Integral (PI) controller, abbreviated as PI-MPTC. The pole placement of the PI controller is usually designed by a plunge-and-test, and it is difficult to achieve optimal dynamic performance and optimal suppression of concentrated disturbances at the same time. Aiming at squirrel cage induction motors, this paper first proposes an outer-loop F-ETFC-MPTC control strategy based on a feed-forward factor for electromagnetic torque feedback compensation (F-ETFC). The electromagnetic torque was imported to the input of the current regulator, which is used as the control input signal of feedback compensation of the speed loop; therefore, the capacity of an anti-load-torque-disturbance of the speed loop was improved. The given speed is quantified by a feed-forward factor into the input of the current regulator, which is used as the feed-forward adjustment control input of the speed controller to improve the dynamic response of the speed loop. The range of the feed-forward factor and feed-back compensation coefficient can be obtained according to the structural analysis of the system, which simplifies the process of parameter design adjustment. At the same time, the multi-objective optimization based on the sorting method replaces the single cost function in traditional control, so that the selection of the voltage vector works without the weight coefficient and can solve complicated calculation problems in traditional control. Finally, according to the relationship between the voltage vector and the switch state, the virtual six groups of three vector voltages can be adjusted in both the direction and amplitude, thereby effectively improving the control performance and reducing the flow rate and torque ripple. The experiment is based on the dSPACE platform, and experimental results verify the feasibility of the proposed F-ETFC-MPTC. Compared with traditional PI-MPTC, the feed-forward factor can effectively improve the stability time of the system by more than 10 percent, electromagnetic torque feedback compensation can improve the anti-load torque disturbance ability of the system by more than 60 percent, and the three-vector voltage method can effectively reduce the disturbance.</jats:p