69 research outputs found

    Demonstration of public participation and communication through social media in the network society within Shanghai

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    The rapid development of information and communication technology has led to the Internet and social media becoming a vital platform for public participation in China. The present research sought to understand the complexity of participation in the network society by taking the cancellation of the number 55 bus route in Shanghai as a case study. Both qualitative and quantitative research methods were used to analyze data from a leading social networking site in China. An analysis of participation patterns led to an understanding of the main characteristics of public participation in the network society, and a statistical analysis of the network revealed the features of elite participants in the planning adjustment. A qualitative approach was also used to explore the communication process, which was influenced by Chinese social capitalguanxi. The case study revealed an uneven pattern of public participation in the network society, and suggestions are provided to enhance fairness and effectiveness in this process

    Rethinking collaborative planning in China: Does the communicative or agonistic planning theory matter?

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    There has been considerable debate about Habermasian-inspired communicative planning theory and Mouffe’s-inspired agonistic planning theory. This study investigates the possibility of the communicative and agonistic approaches for collaborative planning in the Chinese context. It examines three common theoretical dimensions, regarding the political concept, the public sphere and the power relation. The recent political development in China is related to authoritarian deliberation, in which governments allow some space for deliberation and participation but with limited empowerment. The multiple tensions between governments and society lead to the fragmentation of public spheres and various forms of power relations in collaborative practices. This study concludes that a dichotomous perspective is not helpful to understand China’s collaborative planning, which reflects features of both communicative and agonistic approaches

    Формування субрегіонів як напрям підвищення конкурентоспроможності та інвестиційної активності території

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    Характерною особливістю регіону є виконання ним не тільки економічних, а й соціальних функцій. Саме тут криється принципова відмінність між різними ланками відтворювального процесу. Кінцева мета відтворювального процесу регіону – матеріальний добробут населення, покращення навколишнього середовища, створення нормальних умов для праці й відпочинку, можливостей духовного розвитку особи і т. п

    Governance Networks and Accountability Patterns in the Provision of Housing for Migrants: The Case of Central and Eastern European Workers in the Netherlands

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    Sub-standard living conditions among migrant workers have become a structural feature all over Europe. Although this has attracted the attention of many scholars, there is a lack of studies on the complex relations between various stakeholders in governing housing. This study fills this gap by analysing this housing issue from a governance network perspective. Through an analysis of policy documents and interviews with twenty-one stakeholders, we investigated institutional and strategic complexities. The results show that decision-making is complicated by unclear institutional accountability patterns and the diverging strategic interests of various stakeholders. The interrelationship between the loosely defined institutional setting (structure) and the varying interests of involved actors (agency) has led to a policy impasse that is difficult to breach. We argue that a reconsideration of existing accountability patterns is needed to reduce sub-standard housing conditions among migrant workers in the Netherlands

    Identification and Simultaneous Determination of the Main Toxical Pyrrolizidine Alkaloids in a Compound Prescription of Traditional Chinese Medicine: Qianbai Biyan Tablet

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    Qianbai biyan tablet (QT) is a compound prescription of traditional Chinese medicine which is used to treat nasal congestion, rhinitis, and nasosinusitis, with Senecio scandens as its main plant material. Several pyrrolizidine alkaloids (PAs) were reported in Senecio scandens and others of Senecio species. Although Senecio scandens is assigned as the legal plant material of QT, whether replaced use of it by other Senecio plants can bring toxicity is unknown because of the lack of quantitative data about toxic PAs between different Senecio species. In the present study, adonifoline, senkirkine, and another PA presumed as emiline have been identified in QT; however, there was no senecionine detected in all tablets. PA contents in QTs varied in different companies and different batches. Adonifoline existed only in Senecio scandens, and senecionine was detected in all eight Senecio plants investigated in the present study. Data showed that replaced use of Senecio scandens with a low level of senecionine by other Senecio plants such as Senecio vulgaris containing a high level of senecionine is advertised to be forbidden. Data of the present study may be used as a reference to make new drug quality regularity and recommendation guideline for the safety of QT

    The effects of jobs, amenities, and locations on housing submarkets in Xiamen City, China

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    Numerous studies have found that jobs, amenities, and location influence housing prices in urban areas. However, there is still a lack of in-depth understanding of the impacts of these factors on various housing submarkets within a city. With the case study of Xiamen, this paper investigates the impacts of jobs, amenities, and location on four housing submarkets, classified by owner-occupied and rental housing, in inner and outer districts. The hedonic model, Chow test, and Tiao-Goldberger test are applied to analyze differentiation in the determinants of housing prices between four submarkets. The results show that all submarkets are influenced by blue-collar jobs (which have negative effects) and seascape (which has a positive impact). Besides, differentiated after submarkets show that school districts and public transportation have a greater influence on owner-occupied markets than on rental markets. A heterogeneity exists between inner-district and outer-district markets. For instance, bus rapid transit (BRT) has a positive effect on housing and rental prices in the outer districts but not in the inner districts. These differences are mainly caused by the disparities of spatial quality, economic development, and public facilities and amenities. The findings have profound implications for decision-making and planning practices

    High fat diet significantly changed the global gene expression profile involved in hepatic drug metabolism and pharmacokinetic system in mice.

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    Background: High fat diet impact transcription of hepatic genes responsible for drug metabolism and pharmacokinetics. Until now, researches just focused on a couple specific genes without a global profile showing. Age-dependent manner was also not noted well. This study aims to investigate the high fat diet effect on transcriptome of drug metabolism and pharmacokinetic system in mouse livers and show the age-dependent evidence. Methods: C57BL/6 male mice were used in this experiment. High fat diet was used to treat mice for 16 and 38 weeks. Serum total cholesterol, low density lipoprotein cholesterol, aspartate transaminase, and alanine transaminaselevels were measured. Meanwhile, Histology, RNA-Seq, RT-PCR analysis and fourteen major hepatic bile acids quantification were performed for the liver tissues. Data was mined at levels of genes, drug metabolism and pharmacokinetic sysem, and genome wide. Results: Treatment with high fat diet for 38 weeks significantly increased levels of serum lipids as well as aspartate transaminase, and alanine transaminase. Meanwhile, lipid accumulation in livers was observed. At week 38 of the experiment, the profile of 612 genes involved in drug metabolism and pharmacokinetics was significantly changed, indicated by a heatmap visulization and a principal component analysis. In total 210 genes were significantly regulated. Cyp3a11, Cyp4a10, and Cyp4a14 were down-regulated by 10-35 folds, while these three genes also were highly expressed in the liver. High fat diet regulated 11% of genome-wide gene while 30% of genes involved in the hepatic drug metabolism and pharmacokinetic system. Genes, including Conclusions: High fat diet changed the global transcription profile of hepatic drug metabolism and pharmacokinetic system with a age-dependent manner

    Gypenosides Altered Hepatic Bile Acids Homeostasis in Mice Treated with High Fat Diet

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    Abstract Gypenosides extracted from Gynostemma pentaphyllum (Thunb.) Makino have significant role in reducing serum lipid level and treating fatty liver diseases, however, without clear mechanism. As gypenosides share the similar core structures with bile acids (the endogenous ligands of nuclear receptor FXR), we hypothesize that gypenosides may improve hypercholesterolemia via FXR-mediated bile acids signaling. The present study was designed to validate the role of gypenosides in reducing levels of serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C), as well as in regulating bile acids homeostasis and related gene expression levels. The C57BL/6 male mice were divided into four groups. Mice in groups ND and HFD were fed with normal diet and high fat diet for 38 weeks, respectively. In groups HFD+GP and HFD+ST, mice were fed with high fat diet for 38 weeks and treated with gypenosides and simvastatin (positive control) from weeks 16 to 38, respectively. Serum TC and LDL-C levels were assayed by commercially available kits. Expression levels of genes were tested by the quantitative real-time PCR. The LC-MS/MS was applied to quantify major bile acids in mice livers. Our results showed that gypenosides significantly decreased serum TC and LDL-C levels. The gene expression level of Shp was downregulated while the levels of Cyp7a1, Cyp8b1, Fxr, Lrh1, Jnk1/2, and Erk1/2were upregulated by gypenosides. Indicated by LC-MS/MS technology, gypenosides increased the hepatic levels of several free bile acids and most taurine-conjugated bile acids while decreasing glycine-conjugated bile acids levels. In addition, gypenosides decreased the CA/CDCA ratio. Gypenosides may improve the abnormal lipid profile of HFD-fed mice via two pathways: (1) enhancing the bile acids biosynthesis from cholesterol; (2) decreasing the CA/CDCA ratio which is positively related to cholesterol absorption

    Social media for collaborative planning: A typology of support functions and challenges

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    In recent years, the widespread use of social media has increasingly impacted planning practice and policy making. Although a growing body of literature examines the impact of social media on urban governance and planning, there is a lack of theoretical understanding on the extent to which social media can support collaborative planning. This study identifies a typology of support functions of social media: information sharing refers to one-way information flows from government to citizens or from individuals and organizations to a wide audience in real time; social networking is about the networking of individuals and organizations, perhaps crossing geographical boundaries for collective actions; citizen participation is related to different levels of citizen power that may be enhanced by social media; and communication is diverse, characterized by multimodal, interactive and mass self-communication in various online public spheres. These support functions can be employed to assist different phases and scales of collaborative planning. Nevertheless, there are several potential challenges of using social media in urban planning, including population bias, privacy concerns, information credibility, (self-)censorship, and opinion polarization. The integration of social media, digital tools and traditional participation methods can help to support more inclusive planning processes
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