DataSheet_1_CAPRIN2 upregulation by LINC00941 promotes nasopharyngeal carcinoma ferroptosis resistance and metastatic colonization through HMGCR.pdf

Distant metastasis is the main cause of death in nasopharyngeal carcinoma (NPC) patients. There is an urgent need to reveal the underlying mechanism of NPC metastasis and identify novel therapeutic targets. The ferroptosis resistance and survival ability of extracellular matrix (ECM)-detached tumor cells are important factors in determining the success of distant metastasis. In this study, we found that CAPRIN2 contributes to the ferroptosis resistance and survival of ECM-detached NPC cells. Moreover, CAPRIN2 serves as a positive regulator of NPC cell migration and invasion. HMGCR, the key metabolic enzyme of the mevalonate pathway, was identified as the key downstream molecule of CAPRIN2, which mediates its regulation of ferroptosis, survival, migration and invasion of NPC cells. Lung colonization experiments showed that downregulation of the CAPRIN2/HMGCR axis resulted in reduced lung metastasis of NPC cells. Erastin treatment inhibited the ability of NPC cells to colonize the lungs, which was further enhanced by CAPRIN2/HMGCR axis downregulation. Regulated by upstream LINC00941, CAPRIN2 is abnormally activated in NPC, and its high expression is associated with a poor prognosis. In conclusion, CAPRIN2 is a molecular marker of a poor prognosis in NPC, and the LINC00941/CAPRIN2/HMGCR axis provides a new target for the treatment of NPC metastasis and ferroptosis resistance.</p

Realized C–H Functionalization of Aryldiazo Compounds via Rhodium Relay Catalysis

An unprecedented C–H functionalization of aryldiazo compounds without a preinstallation of directing group has been realized under mild conditions, which differs from former reports in its use of diazo compounds as coupling partners in directed C–H activations. This novel transformation has been realized by a rhodium self-relay catalysis, a tandem process of the in situ formation of a directing group and sequential C–H bond activation

Supplementary Material, PSPB-17-106.R2_SupplementaryFile – Effects of Cultural Tightness–Looseness and Social Network Density on Expression of Positive and Negative Emotions: A Large-Scale Study of Impression Management by Facebook Users

<p>Supplementary Material, PSPB-17-106.R2_SupplementaryFile for Effects of Cultural Tightness–Looseness and Social Network Density on Expression of Positive and Negative Emotions: A Large-Scale Study of Impression Management by Facebook Users by Pan Liu, David Chan, Lin Qiu, William Tov and Victor Joo Chuan Tong in Personality and Social Psychology Bulletin</p

Supplementary Material, PSPB-17-106.R2_MethodologyFile – Effects of Cultural Tightness–Looseness and Social Network Density on Expression of Positive and Negative Emotions: A Large-Scale Study of Impression Management by Facebook Users

<p>Supplementary Material, PSPB-17-106.R2_MethodologyFile for Effects of Cultural Tightness–Looseness and Social Network Density on Expression of Positive and Negative Emotions: A Large-Scale Study of Impression Management by Facebook Users by Pan Liu, David Chan, Lin Qiu, William Tov and Victor Joo Chuan Tong in Personality and Social Psychology Bulletin</p

Ag-Coated Ternary Layered Double Hydroxide as a High-Performance SERS Sensor for Aldehydes

Volatile organic compounds (VOCs) are common environmental pollutants and important biomarkers for early diagnosis of lung cancer. However, aldehydes are difficult to detect directly due to their small Raman scattering cross-section and gaseous phase. Here, a Ag-coated ternary layered double hydroxide (LDH) was designed for the detection and identification of various aldehydes. The specific surface area of CoNi-LDH was increased by doping Fe3+, which provides abundant active sites to capture gas molecules. Furthermore, the energy band gap (Eg) was decreased due to the local amorphous FeCoNi-LDH with an extended band tail, promoting the excitonic transition of Fe0.07(CoNi)0.93-LDH. In addition, the Fermi level of Ag prevented the recombination of electron–hole pairs of Fe0.07(CoNi)0.93-LDH, providing a new bridge for charge transfer between the substrate and the molecule. Ag/Fe0.07(CoNi)0.93-LDH presented excellent surface-enhanced Raman scattering (SERS) performance for aldehyde VOCs by modification with 4-aminothiophenol (4-ATP) to capture aldehydes and realized the detection of benzaldehyde (BZA) at 10 ppb. The enhancement and Raman shift of the b2 mode indicated the contribution of chemical enhancement to the SERS system, so the substrate presented good uniformity. The recycling of the SERS substrate is realized based on the reversibility of the Schiff base reaction. These results manifested that Ag/FeCoNi-LDH has a wide prospect in the application in the trace detection of aldehydes

The influences of walking, running and stair activity on knee articular cartilage: Quantitative MRI using T1 rho and T2 mapping

<div><p>Objective</p><p>To explore the different influences of walking, running and stair activity on knee articular cartilage with T1 rho and T2 mapping sequences.</p><p>Materials and methods</p><p>MRI (3.0-T) scans of the right knee were performed in twenty-three young healthy adults immediately after 30 minutes of rest, walking, running and stair activity respectively. Articular cartilage was quantitatively assessed based on T1 rho and T2 relaxation times. Analysis of variance for random block design data, bonferroni test and paired samples t tests were performed to estimate the different influences of physiological activities on articular cartilage.</p><p>Results</p><p>T1 rho and T2 values had reductions after physiological activities in all regions of articular cartilage. T1 rho and T2 values were decreased more after running than walking. T1 rho and T2 values were decreased more after stair activity than running, except for femoral cartilage. The superficial layer of patella cartilage had higher reduction rates than the deep layer. The T1 rho and T2 values of articular cartilage were reduced in the following order: patellofemoral cartilage> medial tibiofemoral cartilage> lateral tibiofemoral cartilage. Patellofemoral cartilage experienced reductions in the following order: lateral part> middle part> medial part. Tibiofemoral cartilage had reductions in the following order: posterior part> middle part> anterior part.</p><p>Conclusions</p><p>T1 rho and T2 mapping sequences can quantitatively reflect the different influences of physiological activities on knee articular cartilage. Fluid shifts, collagen fiber deformation, spatial heterogeneity, inherent differences in material properties and tissue stiffness have close relationship with cartilage loading characteristics.</p></div

I The segmentation of knee cartilage; II The superficial and deep layers of patella cartilage.

<p>Note: PC = patella cartilage, TC = trochlea cartilage, LFC = lateral femoral cartilage, LTC = lateral tibial cartilage.</p

Image_1_An ultrasound-based nomogram model in the assessment of pathological complete response of neoadjuvant chemotherapy in breast cancer.pdf

IntroductionWe aim to predict the pathological complete response (pCR) of neoadjuvant chemotherapy (NAC) in breast cancer patients by constructing a Nomogram based on radiomics models, clinicopathological features, and ultrasound features.MethodsUltrasound images of 464 breast cancer patients undergoing NAC were retrospectively analyzed. The patients were further divided into the training cohort and the validation cohort. The radiomics signatures (RS) before NAC treatment (RS1), after 2 cycles of NAC (RS2), and the different signatures between RS2 and RS1 (Delta-RS/RS1) were obtained. LASSO regression and random forest analysis were used for feature screening and model development, respectively. The independent predictors of pCR were screened from clinicopathological features, ultrasound features, and radiomics models by using univariate and multivariate analysis. The Nomogram model was constructed based on the optimal radiomics model and clinicopathological and ultrasound features. The predictive performance was evaluated with the receiver operating characteristic (ROC) curve.ResultsWe found that RS2 had better predictive performance for pCR. In the validation cohort, the area under the ROC curve was 0.817 (95%CI: 0.734-0.900), which was higher than RS1 and Delta-RS/RS1. The Nomogram based on clinicopathological features, ultrasound features, and RS2 could accurately predict the pCR value, and had the area under the ROC curve of 0.897 (95%CI: 0.866-0.929) in the validation cohort. The decision curve analysis showed that the Nomogram model had certain clinical practical value.DiscussionThe Nomogram based on radiomics signatures after two cycles of NAC, and clinicopathological and ultrasound features have good performance in predicting the NAC efficacy of breast cancer.</p

The T1 rho values of the superficial layer of lateral patella cartilage, the lateral trochlea cartilage and the posterior part of medial tibial cartilage.

<p>The T1 rho values of the superficial layer of lateral patella cartilage, the lateral trochlea cartilage and the posterior part of medial tibial cartilage.</p

ANOVA for random block design data and bonferroni test of patellofemoral cartilage among rest, walking, running and stair activity.

<p>ANOVA for random block design data and bonferroni test of patellofemoral cartilage among rest, walking, running and stair activity.</p