STUDY OF TWO MEDICINAL HERBS LEUCAS ASPERA AND CISTUS LAURIFOLIUS FOR THEIR PROSTAGLANDIN INHIBITORY AND ANTIOXIDANT COMPONENTS

研究科: 千葉大学大学院医学薬学府学位:千大院医薬博甲第薬6

MAKET KRATON PLERED CIRCA : 1675

Maket ini berusaha mengangkat suatu program yang subjeknya cukup menantang yakni, Kraton Plered yang keberadaannya sekarang sudah hancur rata dengan tanah. Pertimbangan kurikuler historis didaktis tetap menjadi acuan seleksi subjek model dan dilakukan secara objektif saintifik, Tentatif Historis Imajinasi Berdasarkan Kesaksian Sejarah Tujuan Penelitian ini adalah sebuah analisis historis pertumbuhan dan perkembangan Kraton Plered serta merupakan visualisasi Kraton Plered beserta lingkungan sekitarnya pada masa Kasultanan Amangkurat Agung (I). Penelitian ini menggunakan metode sejarah yakni, diawali dari penentuan subjek, perumusan problema, survai, pengumpulan sumber, analisa sumber, kesimpulan sementara dan berakhir dengan seminar umum, follow up hasil seminar, disimpulkan dalam bentuk grafis (peta, diagram, Chart, denah, irisan, tampak depan, samping, dan atas) "BLUEPRINT". Berdasarkan blueprint, kerja fisik pembuatan maket dilakukan, yang meliputi langkah memotong, merakit, memasang dan finishing. Hasil penelitian merupakan rekonstruksi sebuah model tiga dimensi berupa maket Kraton Plered beserta kelengkapannya, seperti ilustrasi, fotografi, poster, peta, makalah, bibliografi, dokumen, audio visual, dan sebagainya. Kesemuanya untuk sementara disimpan di Ruang Disply Laboratorium Sejarah, FKIP Unversitas PGRI Yogyakarta, Kampus Unit I lantai I gedung B

2011 University Of New England College Of Osteopathic Medicine Fellowship Recipients

2011 recipients of the University of New England College of Osteopathic Medicine\u27s Peter Morgane Research Fellowship (known then as the Dean’s Research Fellowship)

Chemical functionalization of graphene oxide for improving mechanical and thermal properties of polyurethane composites

Graphene oxide (GO) was chemically functionalized to manufacture polyurethane (PU) composites with improved mechanical and thermal properties. In order to achieve a well exfoliated and stable GO suspension in organic solvent, 4, 4′- methylenebis(phenyl isocyanate) and polycaprolactone diol – two monomers used to synthesize polyurethane – were employed to functionalize GO sequentially. The obtained functionalized GO (FGO) could form homogeneous dispersions in DMF solvent and the PU matrix, as well as provide a good compatibility with the latter. The most efficient improvement in mechanical properties was achieved when 0.4 wt% FGO was added into the PU matrix, corresponding to increases in the tensile stress, elongation at break and toughness by 34.2%, 27.6% and 64.5%, respectively (compared with those of PU). Regarding the thermal stability, FGO/PU 1 wt% showed the largest enhancement, with T2% and T50% 16 °C and 21 °C higher than those for PU, respectively. A significant improvement in both mechanical properties and thermal stability of FGO/PU composites should be attributed to homogeneous dispersion of FGO in the PU matrix and strong interfacial interaction between them

Observation of B+→ψ(3770)K+

journal articl

Data for: 3351368

These datasets are collected by other researchers. They are used to do the experiments on Machine Learning and the relevant results have been published on top AI conference

Additional file 1 of Risk factors for diabetic ketoacidosis in acute pancreatitis patients with type 2 diabetes

Supplementary Material

Table_1_Correlation of tumor mutational burden with prognosis and immune infiltration in lung adenocarcinoma.docx

BackgroundTumor mutational burden (TMB) plays an important role in the evaluation of immunotherapy efficacy in lung adenocarcinoma (LUAD).ObjectiveTo improve the clinical management of LUAD by investigating the prognostic value of TMB and the relationship between TMB and immune infiltration.MethodsTMB scores were calculated from the mutation data of 587 LUAD samples from The Cancer Genome Atlas (TCGA), and patients were divided into low-TMB and high-TMB groups based on the quartiles of the TMB score. Differentially expressed genes (DEGs), immune cell infiltration and survival analysis were compared between the low-TMB and high-TMB groups. We queried the expression of genes in lung cancer tissues through the GEPIA online database and performed experimental validation of the function of aberrant genes expressed in lung cancer tissues.ResultsWe obtained sample information from TCGA for 587 LUAD patients, and the results of survival analysis for the high- and low- TMB groups suggested that patients in the high-TMB group had lower survival rates than those in the low-TMB group. A total of 756 DEGs were identified in the study, and gene set enrichment analysis (GSEA) showed that DEGs in the low-TMB group were enriched in immune-related pathways. Among the differentially expressed genes obtained, 15 immune-related key genes were screened with the help of ImmPort database, including 5 prognosis-related genes (CD274, PDCD1, CTLA4, LAG3, TIGIT). No difference in the expression of PDCD1, CTLA4, LAG3, TIGIT in lung cancer tissues and differential expression of CD274 in lung cancer tissues.ConclusionsThe survival rate of LUAD patients with low TMB was better than that of LUAD patients with high TMB. CD274 expression was down regulated in human LUAD cell lines H1299, PC-9, A549 and SPC-A1, which inhibited malignant progression of A549 cells.</p

DataSheet_5_Correlation of tumor mutational burden with prognosis and immune infiltration in lung adenocarcinoma.zip

BackgroundTumor mutational burden (TMB) plays an important role in the evaluation of immunotherapy efficacy in lung adenocarcinoma (LUAD).ObjectiveTo improve the clinical management of LUAD by investigating the prognostic value of TMB and the relationship between TMB and immune infiltration.MethodsTMB scores were calculated from the mutation data of 587 LUAD samples from The Cancer Genome Atlas (TCGA), and patients were divided into low-TMB and high-TMB groups based on the quartiles of the TMB score. Differentially expressed genes (DEGs), immune cell infiltration and survival analysis were compared between the low-TMB and high-TMB groups. We queried the expression of genes in lung cancer tissues through the GEPIA online database and performed experimental validation of the function of aberrant genes expressed in lung cancer tissues.ResultsWe obtained sample information from TCGA for 587 LUAD patients, and the results of survival analysis for the high- and low- TMB groups suggested that patients in the high-TMB group had lower survival rates than those in the low-TMB group. A total of 756 DEGs were identified in the study, and gene set enrichment analysis (GSEA) showed that DEGs in the low-TMB group were enriched in immune-related pathways. Among the differentially expressed genes obtained, 15 immune-related key genes were screened with the help of ImmPort database, including 5 prognosis-related genes (CD274, PDCD1, CTLA4, LAG3, TIGIT). No difference in the expression of PDCD1, CTLA4, LAG3, TIGIT in lung cancer tissues and differential expression of CD274 in lung cancer tissues.ConclusionsThe survival rate of LUAD patients with low TMB was better than that of LUAD patients with high TMB. CD274 expression was down regulated in human LUAD cell lines H1299, PC-9, A549 and SPC-A1, which inhibited malignant progression of A549 cells.</p

DataSheet_3_Correlation of tumor mutational burden with prognosis and immune infiltration in lung adenocarcinoma.zip

BackgroundTumor mutational burden (TMB) plays an important role in the evaluation of immunotherapy efficacy in lung adenocarcinoma (LUAD).ObjectiveTo improve the clinical management of LUAD by investigating the prognostic value of TMB and the relationship between TMB and immune infiltration.MethodsTMB scores were calculated from the mutation data of 587 LUAD samples from The Cancer Genome Atlas (TCGA), and patients were divided into low-TMB and high-TMB groups based on the quartiles of the TMB score. Differentially expressed genes (DEGs), immune cell infiltration and survival analysis were compared between the low-TMB and high-TMB groups. We queried the expression of genes in lung cancer tissues through the GEPIA online database and performed experimental validation of the function of aberrant genes expressed in lung cancer tissues.ResultsWe obtained sample information from TCGA for 587 LUAD patients, and the results of survival analysis for the high- and low- TMB groups suggested that patients in the high-TMB group had lower survival rates than those in the low-TMB group. A total of 756 DEGs were identified in the study, and gene set enrichment analysis (GSEA) showed that DEGs in the low-TMB group were enriched in immune-related pathways. Among the differentially expressed genes obtained, 15 immune-related key genes were screened with the help of ImmPort database, including 5 prognosis-related genes (CD274, PDCD1, CTLA4, LAG3, TIGIT). No difference in the expression of PDCD1, CTLA4, LAG3, TIGIT in lung cancer tissues and differential expression of CD274 in lung cancer tissues.ConclusionsThe survival rate of LUAD patients with low TMB was better than that of LUAD patients with high TMB. CD274 expression was down regulated in human LUAD cell lines H1299, PC-9, A549 and SPC-A1, which inhibited malignant progression of A549 cells.</p