Overall survival analysis.

<p>Overall survival analysis.</p

Evaluation of <i>K-ras</i> and <i>p53</i> expression in pancreatic adenocarcinoma using the cancer genome atlas

<div><p>Genetic alterations in <i>K-ras</i> and <i>p53</i> are thought to be critical in pancreatic cancer development and progression. However, <i>K-ras</i> and <i>p53</i> expression in pancreatic adenocarcinoma have not been systematically examined in The Cancer Genome Atlas (TCGA) Data Portal. Information regarding <i>K-ras</i> and <i>p53</i> alterations, mRNA expression data, and protein/protein phosphorylation abundance was retrieved from The Cancer Genome Atlas (TCGA) databases, and analyses were performed by the cBioPortal for Cancer Genomics. The mutual exclusivity analysis showed that events in <i>K-ras</i> and <i>p53</i> were likely to co-occur in pancreatic adenocarcinoma (Log odds ratio = 1.599, <i>P</i> = 0.006). The graphical summary of the mutations showed that there were hotspots for protein activation. In the network analysis, no solid association between <i>K-ras</i> and <i>p53</i> was observed in pancreatic adenocarcinoma. In the survival analysis, neither <i>K-ras</i> nor <i>p53</i> were associated with both survival events. As in the data mining study in the TCGA databases, our study provides a new perspective to understand the genetic features of <i>K-ras</i> and <i>p53</i> in pancreatic adenocarcinoma.</p></div

Disease-free survival analysis.

<p>Disease-free survival analysis.</p

Mutation diagram of <i>p53</i> in pancreatic adenocarcinoma.

<p>Mutation diagram of <i>p53</i> in pancreatic adenocarcinoma.</p

The OncoPrint tab.

<p>The OncoPrint tab.</p

Network analysis of the <i>K-ras</i> and <i>p53</i> neighborhood in pancreatic adenocarcinoma.

<p>Network analysis of the <i>K-ras</i> and <i>p53</i> neighborhood in pancreatic adenocarcinoma.</p

Mutation diagram of <i>K-ras</i> in pancreatic adenocarcinoma.

<p>Mutation diagram of <i>K-ras</i> in pancreatic adenocarcinoma.</p