Three types of learning task.

<p>(a) A gene is treated as a sample and owns one GO term only, which is called the single instance single label. (b) A gene is treated as a sample and annotated by multiple GO terms. This relationship between gene and GO terms is multi-label. (c) Multiple genes are treated as samples and share the same GO term. The relationship between genes and GO term is called multi-instance.</p

GO in the last level up-propagate along GO DAG.

<p>(a) The bold GO terms all own at least λ genes. (b) The bold GO terms are in the level of GO DAG.</p

Average AUC obtained from each learning system by MLSVM in all datasets.

<p>Average AUC obtained from each learning system by MLSVM in all datasets.</p

Average AUC obtained from each learning system by MLKNN for each expression dataset.

<p>Average AUC obtained from each learning system by MLKNN for each expression dataset.</p

MIHC algorithm and flow chart of function prediction.

<p>MIHC algorithm and flow chart of function prediction.</p

The ROC of a class obtained from the MIHC learning system by MLSVM for the cdc28 dataset.

<p>The ROC curves of the 20 repetitions of the experiment as well as the four subplots (a), (b), (c), and (d) with parameter n% = 20%, 40%, 60%, and 80%, respectively, are shown.</p

Microfluidic Electrospray of Multifunctional Discal Microparticles for Wound Healing

Attempts to develop an efficient wound dressing have come to the forefront in the field of wound healing. Herein, we employ a microfluidic electrospray device to prepare the novel multifunctional discal microparticles (DMPs) with therapeutics encapsulation for wound healing. The DMPs are derived from the deformation of droplets containing κ-carrageenan and methacrylate-esterified hyaluronic acid. These DMPs possess highly porous structures due to the cross-linking and lyophilization of their hybrid hydrogels. Benefiting from the special discal morphology and porous structures, the DMPs offer candidates to wound dressing with large contact area and excellent drug release ability. By loading vascular endothelial growth factors and antimicrobial peptides, the resultant DMPs were imparted with good biocompatibility, sterilization, and angiogenesis in vitro. We have demonstrated that, in the skin defect model of Sjögren’s syndrome mice, the multifunctional DMPs treated acute wounds could perform accelerated tissue regeneration and remodeling, down-regulated inflammatory response, and promoted angiogenesis in vivo. These results indicated that our proposed DMPs have great potential to serve as a satisfactory dressing for promoting wound healing

Average AUC obtained from cdc28 dataset by MLSVM.

<p>Average AUC obtained from cdc28 dataset by MLSVM.</p

Average TPR and FPR in MIHC by MLSVM.

<p>Average TPR and FPR in MIHC by MLSVM.</p

Average AUC obtained from cdc28 dataset by MLKNN.

<p>Average AUC obtained from cdc28 dataset by MLKNN.</p