Domain-Specific Event Abstraction

Process mining aims at deriving process knowledge from event logs, which contain data recorded during process executions. Typically, event logs need to be generated from process execution data, stored in different kinds of information systems. In complex domains like healthcare, data is available only at different levels of granularity. Event abstraction techniques allow the transformation of events to a common level of granularity, which enables effective process mining. Existing event abstraction techniques do not sufficiently take into account domain knowledge and, as a result, fail to deliver suitable event logs in complex application domains.This paper presents an event abstraction method based on domain ontologies. We show that the method introduced generates semantically meaningful high-level events, suitable for process mining; it is evaluated on real-world patient treatment data of a large U.S. health system

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

Die Juden der Freien Stadt Danzig unter der Herrschaft des Nationalsozialismus

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Erwin Lichtenstein Collection ; 1926-1989

The Erwin Lichtenstein Collection documents the work of Erwin Lichtenstein as an author. The bulk of the archival collection is in reference to his book "Die Juden der Freien Stadt Danzig unter der Herrschaft des Nationalsozialismus 1933-1945". The correspondence with Sam Echt, Werner Feilchenfeld, Ernst Loops and others reflect the response to Erwin Lichtenstein's publication. Noteworthy with regard to the book is the correspondence between Günter Grass and Erwin Lichtenstein. Although the bulk of the documents consists of correspondence, the collection also includes newspaper articles and book reviews, corrections and changes and the original manuscript of the aforementioned book.Walter Friedlaender ; Herbert Perlman (1948) ; Dr. Ludwig Hollaender (1935) ; deportations and death of Max Lichtenstein in Theresienstadt ; sister Kaethe Lichtenstein ; dissertation of Max Lichtenstein ; Rabbi Neuhaus ; Max Vogelstein and Hermann Vogelstein ; Max Fuerst ; John Vogelstein ; Trott von Solz ; Julie Braun-Vogelstein ; Blumenfeld, Diana ; Turkow, Jonas ; Hamburger, Ernst ; Hollaender, LudwigErwin Lichtenstein was born February 16, 1901 in Koenigsberg (today Kaliningrad, Russia). He was the son of the lawyer (Justizrat) Dr. Max Lichtenstein. Erwin Lichtenstein studied law at the universities of Koenigsberg, Berlin and Leipzig. In 1922 he completed his doctoral studies. Afterwards he was a lawyer for the National Association of the ‘Centralverein deutscher Staatsbürger mit jüdischem Glauben’ in East Prussia. 1923-1926 he was the editor of the weekly "Danziger Rundschau". He practiced law in Germany from 1930-1933. After his exclusion from the bar, due to being Jewish, he returned to Danzig (Gdansk, Poland). He was the head of the relief organization of the Jewish Centralwohlfahrtstelle. From 1933 until his emigration in 1939 to Tel Aviv, Lichtenstein was the head of the Danzig Jewish Community and he was also editor of the ‘Jüdisches Gemeindeblatt’. In 1953, he started to practice law in Israel. In 1973 Erwin Lichtenstein published "Die Juden der Freien Stadt Danzig unter der Herrschaft des Nationalsozialismus 1933-1945" for the Leo Baeck Institute.Erwin Lichtenstein's book may be found in the LBI Library, call number DS 135 G4 D35 L53digitizedJüdisches Gemeindeblatt.Juedisches Gemeindeblat

[Membership announcement] / : Jüdische Buch-Vereinigung E.V., die Geschäftsführer Dr. Erich Lichtenstein, Erwin Löwe.

Insert into a Jüdische Buch-Vereinigung imploring members to recruit new members, with attached membership application form.Processed for digitizationSent for digitizationReturned from digitizationLinked to online manifestationdigitize

"Kameraden" : Verbandszeitschrift des Jugendverbandes jüdischer Deutscher "Kameraden".

The first "Wanderverein" with the name "Kameraden" began in 1916 in Breslau. In 1919, the many other local "Kameraden" organizations that had sprung up banded together to form a nationwide organization. The "Kameraden" were different from other Jewish youth organizations of the time because they were not Jewish nationalists or Zionists and they oriented themselves toward middle class, assimilated Jews. The goal was to promote the development of spiritually and physical sound Jewish youth who felt they were a part of both German society and the Jewish religious community. The organization took a neutral position on religion because the differences in belief within the Jewish community.Recataloging - Updated item and HOL records; Edited bib record (300, 310, PRS fields); linked to microfilm record.Recataloging - edited record for digitization.Edited bib. record (300, PRS fields); linked to microfilm record; updated HOL and item record

Recent Status and Prospects of the EU-funded ALPINE Project

The ALPINE project is developing innovative fiber lasers for the scribing of new thin film photovoltaic modules with the aims to push forward the European research and development of fiber laser systems and solar energy exploitation. The fiber lasers will be based on photonic crystal fibers, which are characterized by unusual and interesting light guiding properties exploited to deliver high power with excellent beam quality and high resonator stability and efficiency, and will be applied to substitute mechanical scribing steps in the photovoltaic module production. In addition, new photovoltaic thin film technologies is applied, which is based on cadmium telluride and copper indium diselenide materials. With a potential conversion efficiency just below that of crystalline silicon, these new material approaches are ready to enter the market with low manufacturing costs for immediate economic or environment impact.JRC.F.8-Renewable Energy (Ispra

Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients

Late-onset inflammatory toxicities resembling hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS) occur after chimeric antigen receptor T cell (CAR T cell) infusion and represent a therapeutic challenge. Given the established link between perforin deficiency and primary HLH, we investigated the role of perforin in anti-CD19 CAR T cell efficacy and HLH-like toxicities in a syngeneic murine model. Perforin contributed to both CD8+ and CD4+ CAR T cell cytotoxicity but was not required for in vitro or in vivo leukemia clearance. Upon CAR-mediated in vitro activation, perforin-deficient CAR T cells produced higher amounts of proinflammatory cytokines compared with WT CAR T cells. Following in vivo clearance of leukemia, perforin-deficient CAR T cells reexpanded, resulting in splenomegaly with disruption of normal splenic architecture and the presence of hemophagocytes, which are findings reminiscent of HLH. Notably, a substantial fraction of patients who received anti-CD22 CAR T cells also experienced biphasic inflammation, with the second phase occurring after the resolution of cytokine release syndrome, resembling clinical manifestations of HLH. Elevated inflammatory cytokines such as IL-1β and IL-18 and concurrent late CAR T cell expansion characterized the HLH-like syndromes occurring in the murine model and in humans. Thus, a murine model of perforin-deficient CAR T cells recapitulated late-onset inflammatory toxicities occurring in human CAR T cell recipients, providing therapeutically relevant mechanistic insights