2 research outputs found

    Naphthomycins L–N, Ansamycin Antibiotics from <i>Streptomyces</i> sp. CS

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    Previous analyses of the naphthomycin biosynthetic gene cluster and a comparison with known naphthomycin-type products from <i>Streptomyces</i> sp. CS have suggested that new products can be found from this strain. In this study, screening by LC-MS of <i>Streptomyces</i> sp. CS products formed under different culture conditions revealed several unknown peaks in the product spectra of extracts derived from oatmeal medium cultures. Three new naphthomycins, naphthomycins L (<b>1</b>), M (<b>2</b>), and N (<b>3</b>), and the known naphthomycins A (<b>4</b>), E (<b>5</b>), and D (<b>6</b>) were obtained. The structures were elucidated using spectroscopic data from 1D and 2D NMR and HRESIMS experiments

    One-Step Semisynthesis Method of Spirocurcasone and Pyracurcasone from Curcusones A and B

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    High contents of curcusones A and B and trace amounts of spiro­curcasone exist in the roots of Jatropha curcas. Here, a one-step semi­synthesis method of spiro­curca­sone and pyra­curca­sone was built, not only resulted an increased yield of spiro­curca­sone but also produced pyra­curca­sone, which exhibited greater cytotoxicity compared to curcusones A and B. The plausible mechanism of the formation of pyra­curca­sone was proposed, and the proposed biogenetic origin for spiro­curcasone by Taglialatela-Scafati was confirmed
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