36 research outputs found

    ROC curve for the ADMA levels in predicting adverse events.

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    <p>The area under the curve for ADMA levels in predicting adverse events was 0.767 (95% confidence interval  =  0.654–0.879). ADMA  =  asymmetric dimethylarginine; ROC curve  =  receiver-operator characteristics curve.</p

    ADMA levels in AF and non-AF patients.

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    <p>The ADMA levels were higher in AF patients compared to non-AF patients. In addition, non-PAF patients had higher levels of ADMA than PAF patients. ADMA  =  asymmetric dimethylarginine; AF  =  atrial fibrillation; PAF  =  paroxysmal atrial fibrillation. *P value <0.05, PAF or non-PAF versus no AF. <sup>+</sup>P value <0.05, Non-PAF versus PAF.</p

    Event-free survival curve for patients with different ADMA levels.

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    <p>Kaplan-Meier survival analysis showed that the patients with an ADMA level ≥ 0.55 µmol/L were associated with a higher event rate compared to patients with an ADMA level <0.55 µmol/L (33.3% versus 9.3%, p = 0.001). ADMA  =  asymmetric dimethylarginine.</p

    Linear regression models on the relationship between PA-PDI interval and pericardial fat.

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    <p>hs-CRP = high sensitivity C-reactive protein; LV = left ventricle; LVEF = left ventricular ejection fraction; LVIDD = left ventricular internal dimension at end-diastole; SE = standard error; WBCs = white blood cells.</p

    A novel noninvasive surface ECG analysis using interlead QRS dispersion in arrhythmogenic right ventricular cardiomyopathy

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    <div><p>Background</p><p>This study investigated the feasibility of using the precordial surface ECG lead interlead QRS dispersion (IQRSD) in the identification of abnormal ventricular substrate in arrhythmogenic right ventricular cardiomyopathy (ARVC).</p><p>Methods</p><p>Seventy-one consecutive patients were enrolled and reclassified into 4 groups: definite ARVC with epicardial ablation (Group 1), ARVC with ventricular tachycardia (VT, Group 2), idiopathic right ventricular outflow tract VT without ARVC (Group 3), and controls without VT (Group 4). IQRSD was quantified by the angular difference between the reconstruction vectors obtained from the QRS-loop decomposition, based on a principal component analysis (PCA). Electroanatomic mapping and simulated ECGs were used to investigate the relationship between QRS dispersion and abnormal substrate.</p><p>Results</p><p>The percentage of the QRS loop area in the Group 1–2 was smaller than the controls (P = 0.01). The IQRSD between V1-V2 could differentiate all VTs from control (P<0.01). Group 1–2 had a greater IQRSD than the Group 3–4 (V4-V5,P = 0.001), and Group 1 had a greater IQRSD than Group 3–4 (V6-Lead I, P<0.001). Both real and simulated data had a positive correlation between the maximal IQRSD (γ = 0.62) and the extent of corresponding abnormal substrate (γ = 0.71, both P<0.001).</p><p>Conclusions</p><p>The IQRSD of the surface ECG precordial leads successfully differentiated ARVC from controls, and could be used as a noninvasive marker to identify the abnormal substrate and the status of ARVC patients who can benefit from epicardial ablation.</p></div

    Measurement of pericardial adipose tissue.

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    <p>The PCF (*) was defined by the fat between the heart and the pericardium (arrow) as shown in axial view (A). Thick-slice (10 mm) 3D reconstruction axial view (B) demonstrated PCF. All pixels within a window of −195 to −45 HU and a window centre of −120 HU inside pericardial sac have been selected as PCF and reconstructed into the 3D image. PCF = pericardial fat.</p

    ROC curve for PA-PDI interval in predicting an increased amount of pericardial fat (third tertile).

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    <p>The AUC for the PA-PDI interval in predicting an increased amount of PCF (third tertile, ≥91.9 mL) was 0.796 (95% CI = 0.745–0.848, p value <0.001). At a cutoff value of 130 ms identified by the ROC curve, the sensitivity and specificity of PA-PDI interval in identifying patients with a highest tertile amount of PCF were 63.4% and 85.3%, respectively. AUC = area under the curve; CI = confidence interval; PCF = pericardial fat; ROC = receiver operating characteristic.</p

    An example of the atrium electromechanical interval (PA-PDI interval) measurement.

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    <p>In the apical four chamber view, the pulse-wave Doppler sample was placed on the mitral inflow tract. The PA-PDI interval was defined as the time-interval from the initiation of the P wave from the electrocardiographic signal (lead II) provided by the echocardiographic machine to the peak of the mitral inflow A wave of the pulse wave Doppler imaging.</p

    The association between PA-PDI interval and pericardial fat.

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    <p>The PA-PDI interval was significantly correlated with the amount of PCF (r = 0.641, p value <0.001) (A). When patients were divided into 3 groups according to the tertile values of PCF, the PA-PDI interval continuously lengthened from first (115.8±12.4 ms), second (125.0±9.3 ms) to third tertile (135.1±12.8 mm) (B). *P value <0.05, second or third tertile versus first tertile; <sup>+</sup>P value <0.05, third versus second tertile. PCF = pericardial fat.</p
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