Structural diversity and anti-lung cancer activity evaluation of two Co(II) and Cu(II) containing mixed-ligand coordination polymers

In this study, we report the synthesis and structural characterization of two new Co(II) and Cu(II) containing coordination polymers {[Co2(btc)(mbtz)2]·7H2O}n (1), [Cu2(btc)(mbtz)2]n (2) by using the N donor ligand 1,3-bis(1H-1,2,4-triazol-1-ylmethyl)benzene (mbtz) and the O-donor ligand 1,2,4,5-benzenetetracarboxylic acid (H4btc) as the co-linkers. Furthermore, a sonochemical process was used to produce the nanostructures of coordination polymers 1 and 2. Then, we evaluated the anti-viability of nano 1 and 2 on LTEP lung cancer cells. And the Annexin V-FITC/PI staining was performed to detect the apoptosis induced by nano 1 and 2 on LTEP cells. The ROS level in LTEP cells was measured by DCFH-DA assay.</p

Two new Bi(III) and Ce(III) chelates incorporating 1,10-phenanthroline-2,9-dicarboxylic acid: structure elucidation and anti-lung cancer activity study

Reactions of 1,10-phenanthroline-2,9-dicarboxylic acid (H2phenda) with Bi(NO3)3·5H2O or Ce(NO3)3·6H2O under solvothermal conditions yielded two new coordination complexes Bi(NO3)2(phenda)2(H2O)3 (1) and [Ce(SO4)(phenda)2(H2O)6](H2O)2 (2). The structures of the two complexes have been elucidated via elemental analyses and single crystal X-ray diffraction analysis. The results show that complex 1 is a discrete binuclear structure based on two seven-coordinated Bi(III) ions while complex 2 is a 1D v-shape chain structure based on two nine-coordinated Ce(III) ions. Furthermore, the anti-lung cancer activity of the complexes has been evaluated via the Cell Counting Kit-8 (CCK-8) assays.</p

Synthesis, characterization and anti-lung cancer activity of two transition metal coordination polymers based on the imidazole-containing ligands

This work presents the synthesis and characterization of two new transition metal coordination polymers [Co(tib)2](NO3)2 (1, tib = 1,3,5-tris(1-imidazolyl)benzene) and [Cd4(bib)5(HCOO)8](DMF)3 (2, bib = 4,4′-bisimidazolylbiphenyl) have been successfully prepared by using two imidazole-containing ligands with different geometers. All structures have been fully elucidated by single-crystal X-ray diffraction along with the elemental analysis. The structural solution and refinement results based on the crystal data collected at room temperature reveal that complex 1 shows a 2D layered structure with a binodal (3,6)-connected kgd topological net, while complex 2 also demonstrates a 2D framework but reflecting a 4-connected sql topological net. Furthermore, the anti-lung cancer activity of the two complexes has been studied via the Cell Counting Kit-8 (CCK-8) assay along with the corresponding action mechanism.</p

Synthesis, molecular docking studies of formononetin derivatives as potent Bax agonists for anticancer activity

Formononetin as a Bax agonist exhibits anticancer effects. To identify novel Bax agonist, 18 new structurally modified formononetin derivatives were synthesised and their anticancer activities were evaluated in the A549 and Beas-2b cell lines. The results indicated that 7a elicited the most potent inhibitory effect against the A549 cell line, with an IC50 value of 0.87 μM, and no obvious toxicity to Beas-2b cells. These results indicated that 7a was 40-fold and 6.94-fold more efficacious than Formononetin and Doxorubicin, respectively. Additionally, western blot and immunofluorescence assays demonstrated that 7a downregulated the protein expression of Bcl-2 and upregulated the expressions of Bax to promote A549 apoptosis, the obtained results also suggested that 7a had the potential to be developed into a lead compound that can be applied in the prevention and treatment of lung cancer.</p