The Destination

It is sometimes difficult to realize that you are making progress, especially in medical school. You fight your way through the dark woods, getting scratched by loose branches, not quite sure if your feet are pointed in the right direction. Sometimes the journey feels like the mountain is collapsing, your feet are falling under you, your fingers throb from frost bite. Yet, there are the days where you stop and see the beauty of the journey in front of you. The winter is not always a cold, barren place, it holds so much beauty and it is worth the fight to continue

Table_1_A causality between fruit consumption and colorectal cancer: a two-sample Mendelian randomization analysis.xlsx

BackgroundColorectal cancer (CRC) significantly threatens human health with increasing incidence and mortality. A debate continues whether fruit consumption is associated with CRC, despite dietary habits having an impact on the disease. The study aims to examine the causal relationship between fruit consumption and CRC based on a two-sample Mendelian randomization method (MR).MethodsSummary statistics for fruit consumption and CRC were obtained from the UK Biobank and the FinnGen Consortium, respectively. Analysis methods used in this study included the inverse-variance weighted (IVW), MR Egger, weighted median, simple mode, and weighted mode. Heterogeneity and horizontal pleiotropy were also assessed. Additionally, a leave-one-out analysis was performed to validate the robustness of the results.ResultsWe found that fruit consumption was associated with a reduction in CRC risk by the IVW method (P = 0.021). This protective effect was predominantly observed in males (OR 0.374; 95% CI: 0.157-0.892; P = 0.027), while no protective effect was noted in females. However, causal correlations were not observed upon analyzing 16 individual types of fruits. Moreover, our results were unlikely to be influenced by horizontal pleiotropy and heterogeneity. Leave-one-out analysis confirmed the stability of the results.ConclusionOur findings suggest that a genetic predisposition for fruit consumption may be protective against CRC, underscoring the need for further research to elucidate the underlying mechanisms and dietary patterns involved.</p

The communication overhead and storage requirement comparison.

<p>The communication overhead and storage requirement comparison.</p

The login phase.

<p>The login phase.</p

Strain-Engineering the Anisotropic Electrical Conductance of Few-Layer Black Phosphorus

Newly fabricated few-layer black phosphorus and its monolayer structure, phosphorene, are expected to be promising for electronic and optical applications because of their finite direct band gaps and sizable but anisotropic electronic mobility. By first-principles simulations, we show that this unique anisotropic free-carrier mobility can be controlled by using simple strain conditions. With the appropriate biaxial or uniaxial strain (4–6%), we can rotate the preferred conducting direction by 90°. This will be useful for exploring unusual quantum Hall effects and exotic electronic and mechanical applications based on phosphorene

The security comparison.

<p>The security comparison.</p

The computation cost comparison.

<p>The computation cost comparison.</p

Algorithm .

<p>Algorithm .</p

The user registration phase.

<p>The user registration phase.</p

The mechanism of fuzzy extractor.

<p>The mechanism of fuzzy extractor.</p