897 research outputs found

    Melodia : A Comprehensive Course in Sight-Singing (Solfeggio)

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    Melodia is a 1904 book designed to teach sight-singing. The educational plan is by Samuel W. Cole; the exercises were written and selected by Leo R. Lewis. Melodia is presented here as a complete edition and has also been divided into its four separate books.https://scholarworks.sjsu.edu/oer/1000/thumbnail.jp

    Role of Temperature, Dissolved Oxygen, and Backwaters in the Winter Survival of Freshwater Drum (\u3ci\u3eAplodinotus grunniens\u3c/i\u3e) in the Mississippi River

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    Annual winter impingement of large numbers of freshwater drum (Aplodinotus grunniens) on screens of a power station intake on the Mississippi River led to an investigation of the cause of impingement. Impingement occurred most abundantly in winter and early spring and primarily involved juvenile fish. Pronounced drift of moribund and dead fish was found in the main channel above and below the power station in late winter. Laboratory studies indicated that juvenile freshwater drum became disoriented, incapacitated, and suffered increased mortality as water temperature dropped to 1 °C and below. In winter and early spring, temperatures were 0 °C in the main and side channels of the river, but pockets of water above 1 °C existed in some backwaters. Dissolved oxygen concentrations declined through the winter, becoming very low in some backwaters. An aggregation of fishes including freshwater drum was observed in the warmer backwaters. Variations in river flow and dissolved oxygen depletion in some backwaters were postulated to cause periodic disruption of the thermal refuges and an associated appearance of incapacitated and dead juvenile freshwater drum in the drift. If man-induced changes to the river eliminate backwater winter refuges, the ichthyofauna of the river could ultimately be altered

    Is the Regge Calculus a consistent approximation to General Relativity?

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    We will ask the question of whether or not the Regge calculus (and two related simplicial formulations) is a consistent approximation to General Relativity. Our criteria will be based on the behaviour of residual errors in the discrete equations when evaluated on solutions of the Einstein equations. We will show that for generic simplicial lattices the residual errors can not be used to distinguish metrics which are solutions of Einstein's equations from those that are not. We will conclude that either the Regge calculus is an inconsistent approximation to General Relativity or that it is incorrect to use residual errors in the discrete equations as a criteria to judge the discrete equations.Comment: 27 pages, plain TeX, very belated update to match journal articl

    Association between statin use after diagnosis of esophageal cancer and survival: a population-based cohort study

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    Background & Aims: Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors), commonly prescribed to prevent cardiovascular disease, promote apoptosis and limit proliferation of esophageal cancer cell lines. We investigated whether statin use following diagnosis of esophageal cancer is associated with reduced esophageal cancer-specific and all-cause mortality.  Methods: We identified a cohort of 4445 men and women in the United Kingdom diagnosed with esophageal cancer from January 2000 through November 2009 using the General Practice Research Database. The National Cancer Registry and Office of National Statistics datasets respectively established the histologic subtype and cancer-specific mortality. Cox proportional hazard regression analysis with time-dependent exposures estimated the association between statin use after diagnosis and esophageal cancer-specific and all-cause mortality.  Results: The median survival time of the entire cohort was 9.2 months (inter-quartile range [IQR], 3.7–23.2 months). Among subjects who used statins after diagnosis of esophageal cancer, the median survival time was 14.9 months (IQR, 7.1–52.3) compared to 8.1 months for non-users (IQR, 3.3–20). In the entire cohort, statin use after diagnosis was associated with a decreased risk of esophageal cancer-specific mortality (adjusted hazard ratio [HR], 0.62; 95% confidence interval [CI], 0.44–0.86) and all-cause mortality (HR, 0.67; 95% CI, 0.58–0.77). In patients with esophageal adenocarcinoma, statin use after diagnosis was associated with decreased risk of esophageal cancer-specific mortality (HR, 0.61; 95% CI 0.38–0.96) and all-cause mortality (HR, 0.63; 95% 0.43–0.92). This effect was not observed in patients with esophageal squamous cell carcinoma. There was no evidence for effect modification of these associations with statin use before cancer diagnosis.  Conclusions: In a large population-based cohort, statin use after diagnosis of esophageal adenocarcinoma, but not esophageal squamous cell carcinoma, was associated with reduced esophageal cancer-specific and all-cause mortality

    In the dedicated pursuit of dedicated capital: restoring an indigenous investment ethic to British capitalism

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    Tony Blair’s landslide electoral victory on May 1 (New Labour Day?) presents the party in power with a rare, perhaps even unprecedented, opportunity to revitalise and modernise Britain’s ailing and antiquated manufacturing economy.* If it is to do so, it must remain true to its long-standing (indeed, historic) commitment to restore an indigenous investment ethic to British capitalism. In this paper we argue that this in turn requires that the party reject the very neo-liberal orthodoxies which it offered to the electorate as evidence of its competence, moderation and ‘modernisation’, which is has internalised, and which it apparently now views as circumscribing the parameters of the politically and economically possible

    Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium

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    Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n = 14 260), velocity of sound (VOS; n = 15 514) and BMD (n = 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n = 11 452) and new genotyping in 15 cohorts (de novo n = 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 × 10(-8)) associations with heel bone properties. Alongside SNPs within or near previously identified osteoporosis susceptibility genes including ESR1 (6q25.1: rs4869739, rs3020331, rs2982552), SPTBN1 (2p16.2: rs11898505), RSPO3 (6q22.33: rs7741021), WNT16 (7q31.31: rs2908007), DKK1 (10q21.1: rs7902708) and GPATCH1 (19q13.11: rs10416265), we identified a new locus on chromosome 11q14.2 (rs597319 close to TMEM135, a gene recently linked to osteoblastogenesis and longevity) significantly associated with both BUA and VOS (P < 8.23 × 10(-14)). In meta-analyses involving 25 cohorts with up to 14 985 fracture cases, six of 10 SNPs associated with heel bone properties at P < 5 × 10(-6) also had the expected direction of association with any fracture (P < 0.05), including three SNPs with P < 0.005: 6q22.33 (rs7741021), 7q31.31 (rs2908007) and 10q21.1 (rs7902708). In conclusion, this GWA study reveals the effect of several genes common to central DXA-derived BMD and heel ultrasound/DXA measures and points to a new genetic locus with potential implications for better understanding of osteoporosis pathophysiology
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