Loop corrections for Kaluza-Klein AdS amplitudes

Recently we conjectured the four-point amplitude of graviton multiplets in ${\rm AdS}_5 \times {\rm S}^5$ at one loop by exploiting the operator product expansion of $\mathcal{N}=4$ super Yang-Mills theory. Here we give the first extension of those results to include Kaluza-Klein modes, obtaining the amplitude for two graviton multiplets and two states of the first KK mode. Our method again relies on resolving the large N degeneracy among a family of long double-trace operators, for which we obtain explicit formulas for the leading anomalous dimensions. Having constructed the one-loop amplitude we are able to obtain a formula for the one-loop corrections to the anomalous dimensions of all twist five double-trace operators.Comment: 37 pages. One ancillary file containing data on the correlator

Evaluation of unclassified variants in the breast cancer susceptibility genes and using five methods: results from a population-based study of young breast cancer patients-0

<p><b>Copyright information:</b></p><p>Taken from "Evaluation of unclassified variants in the breast cancer susceptibility genes and using five methods: results from a population-based study of young breast cancer patients"</p><p>http://breast-cancer-research.com/content/10/1/R19</p><p>Breast Cancer Research : BCR 2008;10(1):R19-R19.</p><p>Published online 19 Feb 2008</p><p>PMCID:PMC2374975.</p><p></p

Time Trends in Per- and Polyfluoroalkyl Substances (PFASs) in California Women: Declining Serum Levels, 2011–2015

After several decades of widespread use, some per- and polyfluoroalkyl substances (PFASs) were phased-out of use due to concerns raised by their persistent, bioaccumulative, and toxic properties. Our objective was to evaluate temporal trends in serum PFAS levels among 1257 middle-aged and older California women (ages 40–94) during a four year period, beginning approximately 5–10 years after these phase-outs began. An online SPE-HPLC-MS/MS was used to measure 10 long-chain PFASs in serum from blood collected cross-sectionally during 2011–2015 from a subset of participants in the California Teachers Study. Results from multivariable linear regression analyses indicated that serum concentrations of nearly all PFASs declined on average 10% to 20% per year. Serum levels of perfluorohexanesulfonic acid (PFHxS) did not significantly decline. With the exception of PFHxS, the downward trend in serum concentrations was evident for all PFASs across all ages, although declines were comparatively steeper among the oldest women. These findings suggest that the phase-out of some common PFASs has resulted in reduced human exposures to them. The lack of a decline for PFHxS suggests that these exposures may be ongoing and underscores the importance of continued biomonitoring and research efforts to elucidate current pathways of exposure

Association between Serum Polybrominated Diphenyl Ether Levels and Residential Proximity to Solid-Waste Facilities

As consumer products treated with polybrominated diphenyl ethers (PBDEs) reach the end of their life cycle, they often are discarded into solid-waste facilities, offering a potential reservoir for exposure. The likelihood of exposures to PBDEs by residents living near those sites rarely has been explored. This study collected blood samples from 923 female participants in the California Teachers Study in 2011–2013 and examined the association between participants’ residential proximity to solid-waste facilities with potential release of PBDEs and serum levels of three congeners (BDE-47, BDE-100, and BDE-153). General linear regression analysis was used to examine the association, adjusting for age, race, body-mass index, neighborhood socioeconomic status, and urban residency. Compared to participants living >10 km from any selected site, those living within 2 km had 45% higher BDE-47 (95% CI: 5–100%) and BDE-100 (95% CI: 0–109%) levels, and those living between 2 and 10 km had 35% higher BDE-47 (95% CI: 0–82%) and 29% higher BDE-100 (95% CI: −9 to 82%) levels. No associations were found for BDE-153. Living close to some solid waste sites may be related to higher serum BDE-47 and BDE-100 levels. Studies with comprehensive exposure assessments are needed to confirm these initial observations

Selected baseline characteristics of 121,004 eligible women in the California Teachers Study by number of full-term pregnancies at baseline.

<p>Selected baseline characteristics of 121,004 eligible women in the California Teachers Study by number of full-term pregnancies at baseline.</p

Preliminary Associations between the Detection of Perfluoroalkyl Acids (PFAAs) in Drinking Water and Serum Concentrations in a Sample of California Women

This study compared detection of perfluoroalkyl acids (PFAAs) in public drinking water with PFAA serum concentrations for 1566 California women. PFAA occurrence in drinking water from U.S. EPA’s third Unregulated Contaminant Monitoring Rule (UCMR3) database was linked by residential zip code to study participants. Detectable water concentrations of perfluorooctanoic acid (PFOA) ranged from 0.020 to 0.053 μg/L and of perfluorooctanesulfonic acid (PFOS) from 0.041 to 0.156 μg/L. Forty percent of detectable concentrations exceeded the 2016 Health Advisory Level of 0.07 μg/L for combined PFOA and PFOS concentrations. Serum concentrations of PFOS and PFOA significantly differed between participants with and without detectable measures of these compounds in water (Wilcoxon <i>P</i> ≤ 0.0007). Median serum concentrations of PFOS and PFOA were 29% and 38% higher, respectively, among those with detectable levels in water compared to those without detectable levels. Validation of this approach and replication of these results in other study populations are warranted

Additional file 1: of Systemic therapy for breast cancer and risk of subsequent contralateral breast cancer in the WECARE Study

Table S1. Characteristics of patients diagnosed with ER/PR-positive first breast cancer enrolled in the WECARE I and II Study. Table S2. Risk ratios of contralateral breast cancer associated with different aspects of tamoxifen use among participants diagnosed with ER/PR positive first breast cancer in the WECARE I and II Study. Table S3. Risk ratios of ER-positive and ER-negative contralateral breast cancer associated with different aspects of tamoxifen use among participants diagnosed with ER/PR-positive first breast cancer in the WECARE I and II Study. Table S4. Risk ratios of contralateral breast cancer associated with tamoxifen use by patient and tumor characteristics among participants diagnosed with ER/PR positive first breast cancer in the WECARE I and II Study. (DOCX 59 kb

Temporal Evaluation of Polybrominated Diphenyl Ether (PBDE) Serum Levels in Middle-Aged and Older California Women, 2011–2015

In response to health concerns and widespread human exposures, two widely used commercial formulations of polybrominated diphenyl ethers (PBDEs) were banned in the United States in 2005. Initial biomonitoring data have provided early indications of reduced human exposures since these bans took effect. Our objective was to evaluate temporal trends in PBDE serum levels among a population of older California women during a four-year period, beginning approximately five years after these formulations were banned. Automated solid phase extraction and gas chromatography/high resolution mass spectrometry were used to measure PBDE levels in blood collected during 2011–2015 among 1253 women (ages 40–94) participating in the California Teachers Study. Only congeners with detection frequencies (DF) ≥ 75% were included in the present analysis: BDE-47 (DF = 88%); BDE-100 (DF = 78%); and BDE-153 (DF = 80%). Results from age- and race/ethnicity-adjusted linear regression analyses indicated modest, but statistically significant, average annual percent increases in the serum concentrations of all three PBDEs over the four-year study period. While not without limitations, these results, in the context of other biomonitoring data, suggest that earlier reported declines in PBDE levels may have plateaued and may now be starting to increase. Further biomonitoring to ascertain current trends and determinants of population exposures is warranted

Relative risk estimates and 95% confidence intervals for the association between menstrual and reproductive factors and B-cell NHL risk overall and by histologic subtype in the California Teachers Study.

<p>FTP: Full-term pregnancy RR = relative risk; CI = confidence interval; CLL = chronic lymphocytic leukemia; SLL = small lymphocytic lymphoma.</p>†<p>Adjusted for age at menarche.</p>‡<p>Number of pregnancies/full-term pregnancies and age at first pregnancy/first full-term pregnancy were mutually adjusted for each other.</p>§<p>Adjusted for ever been pregnant.</p>||<p>Limited to women with at least one full-term pregnancy.</p

Additional file 1: Table S1. of Recreational physical activity and risk of triple negative breast cancer in the California Teachers Study

Adjusted hazard ratios for the associations between recreational physical activity and luminal B-like and HER2-enriched invasive breast cancer. (DOCX 22 kb